Roles of MT-ND1 in Cancer

作者：Yi-chun Xu, Jun Su, Jia-jing Zhou, Qing Yuan & Jun-song Han 

Xu, Yc., Su, J., Zhou, Jj. et al. Roles of MT-ND1 in Cancer. CURR MED SCI 43, 869–878 (2023). https://doi.org/10.1007/s11596-023-2771-0

//Abstract

The energy shift toward glycolysis is one of the hallmarks of cancer. Complex I is a vital enzyme complex necessary for oxidative phosphorylation. The mitochondrially encoded NADH: ubiquinone oxidoreductase core subunit 1 (MT-ND1) is the largest subunit coded by mitochondria of complex I. The present study summarizes the structure and biological function of MT-ND1. From databases and literature, the expressions and mutations of MT-ND1 in a variety of cancers have been reviewed. MT-ND1 may be a biomarker for cancer diagnosis and prognosis. It is also a potential target for cancer therapy.