2022年诺贝尔生理学或医学奖揭晓！

https://news.sciencenet.cn/news/sub24.aspx?id=3942

https://news.sciencenet.cn/htmlnews/2022/10/487249.shtm

科学网直播

https://weibo.com/l/wblive/p/show/1022:2321324819526436127559

北京时间10月3日下午5点33分许，2022年诺贝尔生理学或医学奖揭晓。瑞典科学家Svante Pääbo获奖，以表彰他“ 在灭绝古人类基因组和人类进化方面的发现”。

https://www.163.com/dy/article/HIP941JN05118KMO.html

详解2022诺贝尔生理学或医学奖：他创立了一门全新学科，揭示人类因何独一无二

https://mp.weixin.qq.com/s/et8G1mnTr73xhH2Tw7-mAA

检索到文献344篇   

http://www.pubmedplus.cn/P/SearchQuickResult?wd=9305c979-326b-42d8-9f11-106ad9b0de9f

• 1. Analysis of candidate genes for lineage-specific expression changes in humans and primates.

  
  

  Cecilia Lindskog,Martin Kuhlwilm,Armaity Davierwala,Ning Fu,Geeta Hegde,Mathias Uhlén,Sanjay Navani,Svante Pääbo,Fredrik Pontén

  Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University , Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.

  
  

  J Proteome Res (P 1535-3907 E 1535-3893) H指数：145 2014 年 13 卷 8 期 3596-606 页

  PMID：24911366 相似文献

  文摘 DOI链接 American Chemical Society

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  2. Expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight.

  
  

  Sojeong Ka,Ellen Markljung,Henrik Ring,Frank W Albert,Mohammad Harun-Or-Rashid,Per Wahlberg,Pablo M Garcia-Roves,Juleen R Zierath,D Michael Denbow,Svante Pääbo,Paul B Siegel,Leif Andersson,Finn Hallböök

  Department of Neuroscience, Uppsala University, Uppsala, Sweden.

  
  

  Physiol Genomics (P 1531-2267 E 1094-8341) H指数：101 2013 年 45 卷 9 期 367-76 页

  PMID：23512741 相似文献

  文摘 DOI链接 Atypon

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  3. Mitochondrial genome variation and the origin of modern humans.

  
  

  M Ingman,H Kaessmann,S Pääbo,U Gyllensten

  Department of Genetics and Pathology, Section of Medical Genetics, University of Uppsala, Sweden.

  
  

  Nature (P 0028-0836 E 0028-0836) H指数：1096 2000 年 408 卷 6813 期 708-13 页

  PMID：11130070 相似文献

  文摘 DOI链接 Nature Publishing GroupOvid Technologies, Inc.

1.分析人类和灵长类谱系特异性表达变化的候选基因。

Cecilia Lindskog、Martin Kuhlwilm、Armaty Davierwala、Ning Fu、Geeta Hegde、Mathias Uhlén、Sanjay Navani、Svante Päbo、Fredrik Pontén

瑞典乌普萨拉大学生命科学实验室免疫学、遗传学和病理学系，地址：瑞典乌普巴拉SE-751 85，Dag Hammarskjölds väg 20。

蛋白质组研究杂志（P 1535-3907 E 1535-3893）H指数：145 2014 年 13卷 8.期 3596-606 页

项目管理编号：24911366相似文献

文摘 内政部链接 美国化学学会

英 汉

2.肉碱-棕榈酰辅酶a转移酶-1B的表达受顺式作用eQTL的影响，这两个选择用于高体重和低体重的鸡品系。

Sojeong Ka、Ellen Markljung、Henrik Ring、Frank W Albert、Mohammad Harun Or Rashid、Per Wahlberg、Pablo M Garcia Roves、Juleen R Zierath、D Michael Denbow、Svante Pääbo、Paul B Siegel、Leif Andersson、Finn Hallbök

瑞典乌普萨拉大学神经科学系。

生理基因组学（P 1531-2267 E 1094-8341）H指数：101 2013 年 45卷 9期 367-76 页

项目管理编号：23512741相似文献

文摘 内政部链接 阿提蓬牌手表

英 汉

3.线粒体基因组变异与现代人类起源。

M Ingman、H Kaessmann、S Paäbo、U Gyllensten

瑞典乌普萨拉大学医学遗传学科遗传学和病理学系。

性质（P0028-0836 E 0028-0836）H指数：1096 2000 年 408卷 6813期 708-13 页

项目管理编号：11130070相似文献

文摘 内政部链接 自然出版集团Ovid Technologies，股份有限公司。

https://pubmed.ncbi.nlm.nih.gov/11130070/

https://pubmed.ncbi.nlm.nih.gov/?term=P%C3%A4%C3%A4bo+S&cauthor_id=11130070

Erratum in

• Nature 2001 Mar 29;410(6828):611

Abstract

The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of human evolution, owing to characteristics such as high copy number, apparent lack of recombination, high substitution rate and maternal mode of inheritance. However, almost all studies of human evolution based on mtDNA sequencing have been confined to the control region, which constitutes less than 7% of the mitochondrial genome. These studies are complicated by the extreme variation in substitution rate between sites, and the consequence of parallel mutations causing difficulties in the estimation of genetic distance and making phylogenetic inferences questionable. Most comprehensive studies of the human mitochondrial molecule have been carried out through restriction-fragment length polymorphism analysis, providing data that are ill suited to estimations of mutation rate and therefore the timing of evolutionary events. Here, to improve the information obtained from the mitochondrial molecule for studies of human evolution, we describe the global mtDNA diversity in humans based on analyses of the complete mtDNA sequence of 53 humans of diverse origins. Our mtDNA data, in comparison with those of a parallel study of the Xq13.3 region in the same individuals, provide a concurrent view on human evolution with respect to the age of modern humans.

Comment in

• Human evolution. A start for population genomics.

  Hedges SB.Nature. 2000 Dec 7;408(6813):652-3. doi: 10.1038/35047193.PMID: 11130051 No abstract available.

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  Kaessmann H, Heissig F, von Haeseler A, Pääbo S.Nat Genet. 1999 May;22(1):78-81. doi: 10.1038/8785.PMID: 10319866

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  Andreeva TV, Manakhov AD, Gusev FE, Patrikeev AD, Golovanova LV, Doronichev VB, Shirobokov IG, Rogaev EI.Sci Rep. 2022 Jul 29;12(1):13016. doi: 10.1038/s41598-022-16164-9.PMID: 35906446 Free PMC article.

• African mitochondrial haplogroup L7: a 100,000-year-old maternal human lineage discovered through reassessment and new sequencing.

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Publication types

• Research Support, Non-U.S. Gov't

MeSH terms

• Africa

• Animals

• DNA, Mitochondrial*

• Evolution, Molecular*

• Genetic Variation*

• Genome

• Humans

• Mitochondria / genetics*

• Molecular Sequence Data

• Phylogeny

• X Chromosome

Substances

• DNA, Mitochondrial

Associated data

• GENBANK/AF346963

• GENBANK/AF346964

• GENBANK/AF346965

• GENBANK/AF346966

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• GENBANK/AF346970

• GENBANK/AF346971

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• GENBANK/AF346975

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• GENBANK/AF346983

• GENBANK/AF346984

• GENBANK/AF346985

• GENBANK/AF346986

• GENBANK/AF346987

• GENBANK/AF346988

• GENBANK/AF346989

• GENBANK/AF346990

• GENBANK/AF346991

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