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Tu Youyou, female, born on December 30, 1930 in Ningbo, Zhejiang [78], is a member of the Communist Party of China and a pharmacist. In 1951, he was admitted to the Department of Pharmacy, Peking University School of Medicine, majoring in crude drugs. [1-2] Graduated from Beijing Medical College (now Peking University Medical Department) in 1955. After graduation, he received training in traditional Chinese medicine for two and a half years, and has been working in the Chinese Academy of Traditional Chinese Medicine (renamed the Chinese Academy of Traditional Chinese Medicine in 2005), during which he was promoted to master's supervisor and doctoral supervisor. He is now the chief scientist of the Chinese Academy of Traditional Chinese Medicine, [3-5] lifelong researcher and chief researcher [6], director of the Artemisinin Research and Development Center, doctoral supervisor, and winner of the Republic Medal. [7]
He has been engaged in research on combination of traditional Chinese medicine and western medicine for many years, and his outstanding contribution is to create new antimalarial drugs, artemisinin and dihydroartemisinin. In 1972, we successfully extracted the colorless crystal with the molecular formula of C ₁ ₁₁₁₁₁₁₁₁₁₁₁₁₁₁₁₁83. In September 2011, the discovery of artemisinin, a drug used to treat malaria, saved millions of lives in the world, especially in developing countries, and won the Lasker Prize and the "Outstanding Achievement Award in Life Science" of GSK China R&D Center [8]. In October 2015, she won the Nobel Prize in Physiology or Medicine for her discovery of artemisinin, which can effectively reduce the mortality of malaria patients. She became the first Chinese to win the Nobel Prize in science.
The first Chinese native scientist to win the Nobel Science Prize [3]. The Nobel Science Prize is the highest award ever won by the Chinese medical community, and also the highest award for achievements in traditional Chinese medicine. [9]
On January 9, 2017, he won the 2016 National Highest Science and Technology Award. [10] On December 18, 2018, the CPC Central Committee and the State Council awarded Tu Youyou the title of reform pioneer and the medal of reform pioneer. [11] In May 2019, she was selected into Forbes China Science and Technology 50 Women List. [12] In March 2020, she was selected as one of the 100 most influential women in Time magazine. [13]
In 2020, the Chinese Academy of Traditional Chinese Medicine and Shanghai University of Traditional Chinese Medicine will open the "Tu Youyou Class" of Chinese medicine with a nine-year undergraduate course.
屠呦呦,女,1930年12月30日出生于浙江宁波 [78] ,汉族,中共党员,药学家。1951年考入北京大学医学院药学系生药专业。 [1-2] 1955年毕业于北京医学院(今北京大学医学部)。毕业后接受中医培训两年半,并一直在中国中医研究院(2005年更名为中国中医科学院)工作,期间晋升为硕士生导师、博士生导师。现为中国中医科学院首席科学家, [3-5] 终身研究员兼首席研究员 [6] ,青蒿素研究开发中心主任,博士生导师,共和国勋章获得者。 [7]
多年从事中药和西药结合研究,突出贡献是创制新型抗疟药青蒿素和双氢青蒿素。1972年成功提取分子式为C₁₅H₂₅O₅的无色结晶体,命名为青蒿素。2011年9月,因发现青蒿素——一种用于治疗疟疾的药物,挽救了全球特别是发展中国家数百万人的生命获得拉斯克奖和葛兰素史克中国研发中心“生命科学杰出成就奖” [8] 。2015年10月获得诺贝尔生理学或医学奖,理由是她发现了青蒿素,该药品可以有效降低疟疾患者的死亡率。她成为首获科学类诺贝尔奖的中国人。
第一位获诺贝尔科学奖项的中国本土科学家 [3] ,诺贝尔科学奖项是中国医学界迄今为止获得的最高奖项,也是中医药成果获得的最高奖项。 [9]
2017年1月9日获2016年国家最高科学技术奖。 [10] 2018年12月18日,党中央、国务院授予屠呦呦同志改革先锋称号,颁授改革先锋奖章。 [11] 2019年5月,入选福布斯中国科技50女性榜单。 [12] 2020年3月入选《时代周刊》100位最具影响力女性人物榜。 [13]
2020年,中国中医科学院与上海中医药大学开设九年制本博连读中医学“屠呦呦班”。
https://baike.baidu.com/item/%E5%B1%A0%E5%91%A6%E5%91%A6/5567206?fromModule=lemma_inlink
https://pubmed.ncbi.nlm.nih.gov/27488942/
http://www.pubmedplus.cn/P/SearchQuickResult?wd=9163499a-17b8-4270-a02f-0f71063dad77
Review
Angew Chem Int Ed Engl
. 2016 Aug 22;55(35):10210-26.
doi: 10.1002/anie.201601967. Epub 2016 Aug 4.
Affiliations expand
PMID: 27488942
Malaria has long been a devastating and life-threatening global epidemic disease in human history. Artemisinin, the active substance against malaria, was first isolated and tested in the 1970s in China. The important role played by traditional Chinese medicine in the discovery of artemisinin is described by Y. Tu in her Nobel Lecture.
Keywords: artemisinin; malaria; traditional Chinese medicine.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Med Res Rev. 2020 Jul;40(4):1220-1275. doi: 10.1002/med.21657. Epub 2020 Jan 12.PMID: 31930540 Review.
Future Med Chem. 2019 Jun;11(12):1443-1459. doi: 10.4155/fmc-2018-0337. Epub 2019 Jul 12.PMID: 31298579 Review.
Artemisinin: discovery from the Chinese herbal garden.
Cell. 2011 Sep 16;146(6):855-8. doi: 10.1016/j.cell.2011.08.024. Epub 2011 Sep 9.PMID: 21907397 Free PMC article.
J Zhejiang Univ Sci B. 2016 May;17(5):405-8. doi: 10.1631/jzus.B1600094.PMID: 27143269 Free PMC article.
NOBEL PRIZES. Neglected tropical diseases get the limelight in Stockholm.
Science. 2015 Oct 9;350(6257):144-5. doi: 10.1126/science.350.6257.144.PMID: 26450186 No abstract available.
Molecules. 2022 Sep 2;27(17):5678. doi: 10.3390/molecules27175678.PMID: 36080446 Free PMC article. Review.
Commun Biol. 2022 Sep 8;5(1):931. doi: 10.1038/s42003-022-03898-5.PMID: 36076060 Free PMC article.
Dihydroartemisinin remodels macrophage into an M1 phenotype via ferroptosis-mediated DNA damage.
Front Pharmacol. 2022 Aug 11;13:949835. doi: 10.3389/fphar.2022.949835. eCollection 2022.PMID: 36034842 Free PMC article.
Sesquiterpenes from Artemisia annua and Their Cytotoxic Activities.
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CPMCP: a database of Chinese patent medicine and compound prescription.
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Antimalarials / chemistry
Antimalarials / therapeutic use*
Artemisinins / chemistry
Artemisinins / therapeutic use*
Humans
Malaria / drug therapy*
Medicine, Chinese Traditional*
01. | 2022 | 3 篇 | 21.429% |
02. | 2021 | 2 篇 | 14.286% |
03. | 2020 | 3 篇 | 21.429% |
04. | 2019 | 2 篇 | 14.286% |
05. | 2016 | 1 篇 | 7.143% |
06. | 2015 | 1 篇 | 7.143% |
07. | 2011 | 1 篇 | 7.143% |
08. | 2004 | 1 篇 | 7.143% |
01. | lancet | 3 篇 | 21.429% |
02. | lancet infect dis | 2 篇 | 14.286% |
03. | nat med | 2 篇 | 14.286% |
04. | angew chem int ed engl | 1 篇 | 7.143% |
05. | j phys chem lett | 1 篇 | 7.143% |
06. | n engl j med | 1 篇 | 7.143% |
07. | nat prod rep | 1 篇 | 7.143% |
08. | pharmacol ther | 1 篇 | 7.143% |
09. | southeast asian j trop med public health | 1 篇 | 7.143% |
10. | yao xue xue bao | 1 篇 | 7.143% |
01. | 中国 | 13 篇 | 92.857% |
02. | 英国 | 3 篇 | 21.429% |
03. | 德国 | 2 篇 | 14.286% |
04. | 瑞士 | 1 篇 | 7.143% |
05. | 塞内加尔 | 1 篇 | 7.143% |
01. | 中国北京 | 12 篇 | 85.714% |
02. | 中国深圳 | 4 篇 | 28.571% |
03. | 中国上海 | 2 篇 | 14.286% |
04. | 中国湛江 | 2 篇 | 14.286% |
05. | 中国无锡 | 1 篇 | 7.143% |
06. | 中国合肥 | 1 篇 | 7.143% |
07. | 中国西安 | 1 篇 | 7.143% |
01. | Humans | 11 篇 | 78.571% |
02. | Artemisinins | 9 篇 | 64.286% |
03. | Malaria | 9 篇 | 64.286% |
04. | Antimalarials | 7 篇 | 50.000% |
05. | Artemisia annua | 4 篇 | 28.571% |
06. | Malaria, Falciparum | 4 篇 | 28.571% |
07. | Drug Resistance | 3 篇 | 21.429% |
08. | Drug Therapy, Combination | 3 篇 | 21.429% |
09. | Molecular Structure | 3 篇 | 21.429% |
10. | Plasmodium | 3 篇 | 21.429% |
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地址:北京市海淀区远大路20号宝蓝世纪大厦F座5E
Youyou Tu,Weibin Chu,Yongliang Shi,Wenguang Zhu,Qijing Zheng,Jin Zhao
Department of Physics and ICQD/Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China.
J Phys Chem Lett (P 1948-7185 E 1948-7185) H指数:161 2022 年 13 卷 25 期 5766-5775 页
PMID:35723976 相似文献
英
汉
2. The role of research in China's successful elimination of malaria.
Xiaohong Li,Youyou Tu,Linhua Tang,Qi Gao,Pedro L Alonso
Global Malaria Programme, World Health Organization, Geneva, Switzerland. lixia@who.int.
lixia@who.int
Nat Med (P 1546-170X E 1078-8956) H指数:497 2022 年 28 卷 7 期 1336-1338 页
PMID:35641827 相似文献
英
汉
3. Is triple artemisinin-based combination therapy necessary for uncomplicated malaria?
Chengchao Xu,Yin Kwan Wong,Fu Long Liao,Tingliang Jiang,Jigang Wang,Youyou Tu
Shenzhen People's Hospital, Shenzhen, China; Artemisinin Research Centre and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100070, China.
jgwang@icmm.ac.cn
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4. Study towards improving artemisinin-based combination therapies.
Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China. ccxu@icmm.ac.cn yytu@icmm.ac.cn jgwang@icmm.ac.cn.
ccxu@icmm.ac.cn
Nat Prod Rep (P 1460-4752 E 0265-0568) H指数:157 2021 年 38 卷 7 期 1243-1250 页
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5. Triple artemisinin-based combination therapies for malaria: proceed with caution.
Jigang Wang,Chengchao Xu,Yin Kwan Wong,Nan Ma,Fu Long Liao,Tingliang Jiang,Youyou Tu
Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China; Artemisinin Research Center and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100070, China.
yytu@icmm.ac.cn
Lancet (P 1474-547X E 0140-6736) H指数:700 2021 年 396 卷 10267 期 1976 页
PMID:33341138 相似文献
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Nan Ma,Ziyue Zhang,Fulong Liao,Tingliang Jiang,Youyou Tu
Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
yytu@icmm.ac.cn
Pharmacol Ther (P 1879-016X E 0163-7258) H指数:180 2020 年 216 卷 107658 页
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Jigang Wang,Chengchao Xu,Yin Kwan Wong,Fu Long Liao,Tingliang Jiang,Youyou Tu
Shenzhen People's Hospital, Shenzhen, China; Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 100070 Beijing, China.
yytu@icmm.ac.cn
Lancet (P 1474-547X E 0140-6736) H指数:700 2020 年 395 卷 10233 期 e69 页
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8. Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic.
ShenZhen People's Hospital, ShenZhen, China; Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China; Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China.
yytu@icmm.ac.cn
Lancet (P 1474-547X E 0140-6736) H指数:700 2020 年 395 卷 10230 期 1094-1096 页
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文摘 DOI链接 PubMed CentralEurope PubMed CentralClinicalKeyElsevier Science
英
汉
9. Suboptimal dosing triggers artemisinin partner drug resistance.
Jigang Wang,Chengchao Xu,Fu Long Liao,Tingliang Jiang,Sanjeev Krishna,Youyou Tu
Shenzhen People's Hospital, Shenzhen 518020, China; Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
yytu@icmm.ac.cn
Lancet Infect Dis (P 1474-4457 E 1473-3099) H指数:201 2019 年 19 卷 11 期 1167-1168 页
PMID:31657775 相似文献
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10. A Temporizing Solution to "Artemisinin Resistance".
Jigang Wang,Chengchao Xu,Fu Long Liao,Tingliang Jiang,Sanjeev Krishna,Youyou Tu
From the Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (J.W., C.X., F.L.L., T.J., Y.T.), and the ShenZhen People's Hospital, ShenZhen (J.W., C.X.) - both in China; the Department of Pharmacology and Biological Sciences, National University of Singapore, Singapore (J.W., C.X.); the Centre for Diagnostics and Antimicrobial Resistance, Institute for Infection and Immunity, St. George's University of London and St. George's University Hospitals NHS Foundation Trust, London (S.K.); and the Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany (S.K.).
N Engl J Med (P 1533-4406 E 0028-4793) H指数:933 2019 年 380 卷 22 期 2087-2089 页
PMID:31018065 相似文献
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11. Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture).
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Angew Chem Int Ed Engl (P 1521-3773 E 1433-7851) H指数:482 2016 年 55 卷 35 期 10210-26 页
PMID:27488942 相似文献
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12. [STUDIES ON THE CONSTITUENTS OF ARTEMISIA ANNUA L].
Tu Youyou,Ni Muyun,Zhong Yurong,Li Lanna,Gui Shulian,Zhang Muqun,Wang Xiuzhen,Liang Xiaotian
Yao Xue Xue Bao (P 0513-4870 E 0513-4870) H指数:29 2015 年 50 卷 10 期 366-70 页
PMID:26837162 相似文献
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13. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine.
Qinghaosu Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China. youyoutu1930cn@yahoo.com.cn
youyoutu1930cn@yahoo.com.cn
Nat Med (P 1546-170X E 1078-8956) H指数:497 2011 年 17 卷 10 期 1217-20 页
PMID:21989013 相似文献
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Research Center for Qinghao and Qinghaosu, China Academy of Traditional Chinese Medicine, Beijing, China.
Southeast Asian J Trop Med Public Health (P 0125-1562 E 0125-1562) H指数:45 2004 年 35 卷 2 期 250-1 页
PMID:15691118 相似文献
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