近日,国际权威期刊Cell 、Frontiers in Immunology、Epigenetics & Chromatin 上接连发表了乳酸化相关研究成果,报道乳酸化在系统性红斑狼疮、溃疡性结肠炎和胚胎发育中发挥的关键作用,再次扩充了我们对乳酸化修饰生物学功能的新认识。
[Cell]红细胞线粒体滞留产生I型干扰素引发狼疮
狼疮,也被称为系统性红斑狼疮(Systemic lupus erythematosus,SLE),是一种自身免疫疾病。近日,美国威尔康乃尔医学院Virginia Pascual教授团队在 Cell 发表了题为"Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE" 的研究成果。该论文全面介绍了自身免疫性疾病狼疮可能是由红细胞(RBCs)发育过程中的缺陷引发的。这一发现有助于对这种疾病患者进行分类和治疗方法的研发。景杰生物为该研究提供乳酸化抗体。
天津医科大学总医院赵经文教授、王邦茂教授和李炳志教授联合在Frontiers in Immunology上发表题为“Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota” 的研究成果。通过工程化酿酒酵母分泌乳酸抑制巨噬细胞焦化和调节肠道菌群来减轻硫酸葡聚糖钠诱导的小鼠结肠炎,提出了一种有效且安全的溃疡性结肠炎潜在治疗策略。景杰生物为该研究提供乳酸化抗体。
1. Di Zhang, et al. 2019. Metabolic regulation of gene expression by histone lactylation. Nature. 2. Qianying Yang,et al. 2021. A proteomic atlas of ligand-receptor interactions at the ovine maternal-fetal interface reveals the role of histone lactylation in uterine remodeling.Journal Of Biological Chemistry.3.Jie Yu, et al. 2021. Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma.Genome Biology.4. Hideo Hagihara,et al. 2021. Protein lactylation induced by neural excitation.Cell Reports.5. Linpeng Li,et al. 2020.Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade. Nature Metabolism.