还有28天就是2022新年了，这一年过得太快。

临床： 11月份我们小组做了33台手术，其中：

骨质疏松椎体压缩性骨折PVP 11台；腰椎管狭窄或滑脱融合手术9台；腰椎间盘突出椎间孔镜微创手术6台；

颈椎病前路acdf 2台；脊柱肿瘤并脊髓压迫椎管减压内固定术2 台；腰椎间盘突出非融合手术1台；

腰椎间盘突出单纯摘除2台；颈椎并后路单开门1台；Dynesys内固定术后感染清创1台

科研：这段时间一直在对Bone Research文章在修改，补充实验，修改语言，估计还有一周左右时间可以发给编辑。今天将自己简历进行了整理，竟然发现自己作为通讯作者10分以上论文已经6篇了，有点小惊喜，不过也是过去10年努力的结果，希望以后每两年保持1篇10分以上文章的进度发展就很满足了。2022年国自然已经拉开帷幕了，和实验室两个陈博士商量了很久，目前思路基本就绪，还需要做一些前期的数据，2022年国自然，一定要成功哦。

论文列表

(^*代表并列第一作者，^#代表通讯作者)

1.     Chen X*, Tan B*, Bao Z*, Wang S, Tang R, Wang Z, Chen G, Chen S, Lu WW, Yang D^#, Peng S^#.  Enhanced bone regeneration via spatiotemporal and controlled delivery of a genetically engineered BMP-2 in a composite Hydrogel. Biomaterials. 2021 Sep 2;277:121117. doi: 10.1016/j.biomaterials.2021.121117. (IF: 12.479)

2.     Chen X, Tan B, Wang S, Tang R, Bao Z, Chen G, Chen S, Tang W, Wang Z, Long C, Lu WW, Yang D^#, Bian L^#, Peng S^#. Rationally designed protein cross-linked hydrogel for bone regeneration via synergistic release of magnesium and zinc ions. Biomaterials. 2021 May 12; 274: 120895. doi: 10.1016/j.biomaterials.2021.120895. (IF: 12.479)

3.     Wang Z, Zhao J, Tang WJ, Hu LQ, Zou T, Wang JH, Zhou RH, Yang DZ^#, Peng S^#. Multifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Up-Regulate Bone Formation. Small, 2019 Oct;15(41):e1901560. (IF: 13.281)

4.     Chen Z, Zhao F, Liang C, Hu L, Li D, Zhang Y,Yin C, Chen L, Wang L, Lin X, Su P, Ma J, Yang C, Tian Y, Zhang W, Li Y, Peng S^#, Chen W^#, Zhang G^#, Qian A^#. Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli. Theranostics, 2020; 10(26): 12263-12278. (IF: 11.556)

5.     Chen Y, Li C, Wang Z, Long J, Wang R, Zhao J, Tang W, Zhao Y, Qin L, Peng S^#, Lai Y^#. Self-assembled nanocomposite hydrogels enhanced by nanoparticles phosphonate-magnesium coordination for bone regeneration. Applied Materials Today 2021 Dec doi.org/10.1016/j.apmt.2021.101182. (IF: 10.041)

6.     Wang ZM, Wang ZF, Zhen WX, Yang DZ^#, Peng S^#. Novel Biomaterial Strategies for Controlled Growth Factor Delivery for Biomedical Applications. NPG Asia Materials (2017) 9, e435; doi:10.1038/am.2017.171  (IF: 10.03)

7.     Liang C^*, Peng S^* (Co-first author), Li J, et al. Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis. Nature Communications, 2018 Aug 24;9(1):3428. doi: 10.1038/s41467-018-05974-z. (IF: 14.919)

8.     Wang Z*, He X*, He T, Zhao J, Wang S, Peng S^#, Yang D^#, Ye L^#. Polymer Network Editing of Elastomers for Robust Underwater Adhesion and Tough Bonding to Diverse Surfaces. ACS Appl Mater Interfaces. 2021 Jul 27. doi: 10.1021/acsami.1c09239. (IF: 9.229)

9.     Wang Z, Zhao J, Tang W, He T, Wang S, He X, Chen Y^#, Yang D^#, Peng S^#. Robust Underwater Adhesives Based on Dynamic Hydrophilic and Hydrophobic Moieties to Diverse Surfaces. ACS Appl Mater Interfaces. 2021 Jan 20;13(2):3435-3444. (IF: 9.229)

10.   Sun M, Hu L, Wang S, Huang TL, Zhang M, Yang M, Zhen W, Yang DZ, Lu WW, Guan M^#, Peng S^#. MicroRNA-19b Identified from Osteoporotic Vertebral Compression Fracture Patients Increases Bone Formation. J Bone Miner Res, 2020 Feb;35(2):306-316. (IF: 6.471)

11.   Chen G*, Wang S*, Long C, Wang Z, Chen X, Tang W, He X, Bao Z, Tan B, Lu William W, Li Z^#, Yang D^#, Xiao G^#, Peng S^#. PiRNA-63049 inhibits bone formation through Wnt/β-catenin signaling pathway. Int J Biol Sci. 2021Oct 25; 17(15): 4409-4425. (IF: 6.58)

12.   Chen G, Tang W, Wang S, Long C, He X, Yang D, Peng S. Promising diagnostic and therapeutic circRNAs for skeletal and chondral disorders. Int J Biol Sci. 2021 Apr 7;17(5) :1428-1439. (IF: 6.58)

13.   Liu Y, Wang Q, Zhang Z, Fu R, Zhou T, Long C, He T, Yang D^#, Li Z^#, Peng S^#. Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance. Bone. 2021 May;146:115886. doi: 10.1016/j.bone.2021.115886. (IF: 4.398)

14.   Sun T, Li Z, Zhong X, Cai Z, Ning Z, Hou T, Xiong L, Feng Y, Leung F^#, Lu WW^#, Peng S^#. Strontium inhibits osteoclastogenesis by enhancing LRP6 and β-catenin-mediated OPG targeted by miR-181d-5p. J Cell Commun Signal. 2019 Mar;13(1):85-97. (IF: 5.782)

15.   Wang Z, Wang D, Yang D, et al, Peng S^#. The Effect of Icariin on bone metabolism and its potential clinical applications. Osteoporos Int (2017). https://doi.org/10.1007/s00198-017-4255-1. (IF: 4.507)

16.   Sun T, Li CT, Xiong L, Ning Z, Leung F^#, Peng S^#, Lu WW^#. miR-375-3p negatively regulates osteogenesis by targeting and decreasing the expression levels of LRP5 and β-catenin. PLoS One. 2017 Feb 3;12(2):e0171281. doi: 10.1371/journal.pone.0171281. (IF: 3.240)

17.   Sun M, Zhou X, Chen L, Huang S, Leung V, Wu N, Pan H, Zhen W, Lu W, Peng S^#. The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis. Biomed Res Int. 2016;2016:1652417. doi: 10.1155/2016/1652417. (IF: 3.05)

18.   Zhou X, Chen L, Grad S, et al. Peng S^#. The roles and perspectives of microRNAs as biomarkers for intervertebral disc degeneration. J Tissue Eng Regen Med. 2017 Dec;11(12):3481-3487. (IF: 3.963)

19.   Peng S^*, Liu XS, Huang S, Pan H, Zhen W, Zhou G, Luk KD, Guo XE, Lu WW. Intervention Timing of Strontium Treatment on Estrogen Depletion-Induced Osteoporosis in Rats: Bone Microstructure and Mechanics. J Orthop Res, 2014 Mar;32(3):477-84. (IF: 3.26)

20.   Peng S^*, Zhang G, Zhang BT, Guo B, He Y, Bakker AJ, Pan X, Zhen W, Hung L, Qin L, Leung WN. The Beneficial Effect of Icaritin on Osteoporotic Bone is Dependent on the Treatment Initiation Timing in Adult Ovariectomized Rats.  Bone 2013; 55(1):230-40. (IF: 4.398)

21.   Peng S, Zhen W, Lu WW. Osteoprotegerin plays a key role in the dual action of strontium on bone remodeling: Evidences from bench to clinic. Bone 2012, 50:1203-1204. (IF: 4.398)

22.   Peng S^*, Liu XS, Huang S, Li Z, Pan H, Zhen W, Luk KD, Guo XE, Lu WW. The Cross-talk Between Osteoclasts and Osteoblasts in Response to Strontium Treatment: Involvement of Osteoprotegerin. Bone 2011 Dec;49(6):1290-8. (IF: 4.398)

23.   Peng S^*, Liu XS, Zhou G, Li Z, Luk KD, Guo XE, Lu WW. Osteoprogeterin deficiency attenuates strontium-mediated inhibition of osteoclastogenesis and bone resorption J Bone Miner Res 2011 Jun;26(6):1272-82. (IF: 6.471)

24.   Peng S^*, Liu XS, Wang T, Li Z, Zhou G, Luk KD, Guo XE, Lu WW. In vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells. J Orthop Res 2010; 28:1208-1214. (IF: 3.26)

25.   Peng S^*, Zhang G, He Y, Wang X, Leung P, Leung K, Qin L. Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone. Bone 2009; 45:534-544. (IF: 4.398)

26.   Zheng D*, Peng S^*, Yang SH, Shao ZW, Yang C, Feng Y, Wu W, Zhen WX. The beneficial effect of Icariin on bone is diminished in osteoprotegerin-deficient mice. Bone. 2012 Apr 19; 51(1):85-92. (IF: 4.398)

27.   Peng S^*, Zhou G, Luk KD, Cheung KM, Li Z, Lam WM, Zhou Z, Lu WW. Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway. Cell Physiol Biochem 2009; 23:165-174. (IF: 5.14)

家庭：小儿子George在幼儿园连续两次被同学刮破小脸蛋，看得我们很心疼，我也硬着头皮去找了园长，希望他以后在幼儿园1年半的时光，能快乐地度过吧。

疫情还在继续，好像新的变异株又出了，防不胜防啊！期待疫情早点过去，我已经两年多没有出国门了…