Modularity in Jasmonate Signaling for Multistress Resilience

First author: Gregg A. Howe; Affiliations: Michigan State University (密歇根州立大学): East Lansing, USA

Corresponding author: Abraham J. Koo

The plant hormone jasmonate (茉莉酸酯) coosrdinates immune and growth responses to increase plant survival in unpredictable environments. The core jasmonate signaling pathway comprises several functional modules, including a repertoire of COI1–JAZ (CORONATINE INSENSITIVE1–JASMONATE-ZIM DOMAIN) coreceptors (共受体) that couple jasmonoyl-l-isoleucine (茉莉酰-L-异亮氨酸) perception to the degradation of JAZ repressors, JAZ-interacting transcription factors that execute physiological responses, and multiple negative feedback loops to ensure timely termination of these responses. Here, we review the jasmonate signaling pathway with an emphasis on understanding how transcriptional responses are specific, tunable (可调的), and evolvable (可进化的). We explore emerging evidence that JAZ proteins integrate multiple informational cues and mediate crosstalk by propagating (传播) changes in protein–protein interaction networks. We also discuss recent insights into the evolution of jasmonate signaling and highlight how plant-associated organisms manipulate the pathway to subvert (破坏) host immunity. Finally, we consider how this mechanistic foundation can accelerate the rational (合理的) design of jasmonate signaling for improving crop resilience (弹性) and harnessing (利用) the wellspring (泉源) of specialized plant metabolites.

植物激素茉莉酸酯能够响应于不断改变的外部环境来协调植物的生长和免疫。核心的茉莉酸酯信号通路由一些功能模块组成，主要包括COI1–JAZ共受体，能够偶联对茉莉酰-L-异亮氨酸的感知、JAZ抑制子的降解以及JAZ互作转录因子以指导下游生理响应，以及多个负反馈回路保证这些响应的及时终止。本文作者综述了茉莉酸酯信号通路的研究进展，并重点强调了为何转录调控响应是特异性的、可以调控的以及可进化的。作者进一步探索了JAZ蛋白整合多个信号，通过在蛋白-蛋白互作网络中传递变化介导不同模块之间的交联。作者还讨论了近来关于茉莉酸酯信号演化的一些最新研究，并重点阐述了植物相关的生物是如何通过某个通路来破坏植物免疫的。最终，作者提出了目前的研究基础将有利于加速作物育种中通过合理设计茉莉酸酯信号增强作物弹性、并充分利用好一些特异性植物代谢物。

通讯：Abraham J. Koo（https://biochem.missouri.edu/faculty/faculty-members/kooa/index.php）

个人简介：高丽大学，生物学学士；高丽大学，分子生物学和遗传学硕士；密歇根州立大学，植物生物学博士。

研究方向：细胞中小信号分子，可用于检测细胞外部刺激信号，并细胞内外的响应。

doi: https://doi.org/10.1146/annurev-arplant-042817-040047

Journal: Annual Review of Plant Biology 

First Published: 14 March, 2018

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