吴志民分享 http://blog.sciencenet.cn/u/wzm198131 口服胰岛素,希望与转角?!

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口服胰岛素制剂最新文献100篇(2018-2019.2)

已有 2903 次阅读 2019-2-22 10:25 |个人分类:口服胰岛素制剂|系统分类:科研笔记| 口服胰岛素

1.Oral insulin composite microcapsules and manufacturing method thereof (by machine translation). CN104739806, 2018.

2.A oral insulin nano-composite and its preparation method (by machine translation). CN108236720, 2018.

3.Traditional Chinese medicine formula for improving insulin resistance. CN107812134, 2018.

4.A oral insulin nano particle and its preparation method (by machine translation). CN108371708, 2018.

5.A oral insulin [...] grain and its preparation method (by machine translation). CN108478785, 2018.

6.AboulFotouh, K.;  Allam, A. A.;  El-Badry, M.; El-Sayed, A. M., Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability. Colloids and Surfaces B: Biointerfaces 2018, 167, 82 - 92.

7.Achenbach, Asymptomatic early stage type?1 diabetes: Oral insulin as a?preventive treatment. Diabetologe 2018, 14 (4), 234 - 239.

8.Alfatama, M.;  Lim, L. Y.; Wong, T. W., Alginate-C18 Conjugate Nanoparticles Loaded in Tripolyphosphate-Cross-Linked Chitosan-Oleic Acid Conjugate-Coated Calcium Alginate Beads as Oral Insulin Carrier. Molecular Pharmaceutics 2018, 15 (8), 3369 - 3382.

9.Anirudhan, T. S.; Parvathy, J., Novel Thiolated Chitosan-Polyethyleneglycol blend/Montmorillonite composite formulations for the oral delivery of insulin. Bioactive Carbohydrates and Dietary Fibre 2018, 16, 22 - 29.

10.Babbar, R.;  Heni, M.;  Peter, A.;  de Angelis, M. H.;  H?ring, H.-U.;  Fritsche, A.;  Preissl, H.;  Sch?lkopf, B.; Wagner, R. b., Prediction of glucose tolerance without an oral glucose tolerance test. Frontiers in Endocrinology 2018, 9 (MAR).

11.Banerjee, A.;  Ibsen, K.;  Brown, T.;  Chen, R.;  Agatemor, C.; Mitragotri, S., Ionic liquids for oral insulin delivery. Proceedings of the National Academy of Sciences of the United States of America 2018, 115 (28), 7296 - 7301.

12.Barbari, G. R.;  Dorkoosh, F.;  Amini, M.;  Javan, N. B.;  Sharifzadeh, M.;  Atyabi, F.;  Balalaie, S.;  Tehrani, N. R.; Tehrani, M. R., Synthesis and characterization of a novel peptide-grafted cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study. International Journal of Nanomedicine 2018, 13, 5127 - 5138.

13.Bhattacharyya, A.;  Nasim, F.;  Mishra, R.;  Bharti, R. P.; Kundu, Polyurethane-incorporated chitosan/alginate core?shell nano-particles for controlled oral insulin delivery. Journal of Applied Polymer Science 2018, 135 (26).

14.Chen, C. C.;  Baikoghli, M. A.; Cheng, R. H., Tissue targeted nanocapsids for oral insulin delivery via drink. Pharmaceutical Patent Analyst 2018, 7 (3), 121 - 127.

15.Chen, J.;  Liu, R.;  Liu, C.;  Jin, X.;  Zhang, Q.;  Wang, J.;  Zhao, F.;  Wang, Z.;  Qiu, H.;  Li, Y.; Yi, X., Progress of oral insulin and related drug delivery systems and their pharmacokinetics. Current Drug Metabolism 2018, 19 (10), 863 - 870.

16.Chen, Y.;  Li, P.;  Modica, J. A.;  Drout, R. J.; Farha, O. K., Acid-Resistant Mesoporous Metal-Organic Framework toward Oral Insulin Delivery: Protein Encapsulation, Protection, and Release. Journal of the American Chemical Society 2018, 140 (17), 5678 - 5681.

17.Chen, Y.-S.;  Zaro, J. L.;  Zhang, D.;  Huang, N.;  Simon, A.; Shen, W.-C., Characterization and oral delivery of proinsulin-transferrin fusion protein expressed using expresstec. International Journal of Molecular Sciences 2018, 19 (2).

18.Cikrikci, S.;  Mert, B.; Oztop, M. H., Development of pH Sensitive Alginate/Gum Tragacanth Based Hydrogels for Oral Insulin Delivery. Journal of Agricultural and Food Chemistry 2018, 66 (44), 11784 - 11796.

19.Czuba, E.;  Diop, M.;  Mura, C.;  Schaschkow, A.;  Langlois, A.;  Bietiger, W.;  Neidl, R.;  Virciglio, A. l.;  Auberval, N.;  Julien-David, D.;  Maillard, E.;  Frere, Y.;  Marchioni, E.;  Pinget, M.; Sigrist, S. v., Oral insulin delivery, the challenge to increase insulin bioavailability: Influence of surface charge in nanoparticle system. International Journal of Pharmaceutics 2018, 542 (1-2), 47 - 55.

20.Danne, T.;  Heinemann, L.; Bolinder, J., New Insulins, Biosimilars, and Insulin Therapy. Diabetes Technology and Therapeutics 2018, 20 (S1), S55 - S70.

21.Dellepiane, S.;  Ben Nasr, M.;  Assi, E.;  Usuelli, V.;  Letizia, T.;  D'Addio, F.;  Zuccotti, G. V.; Fiorina, P., Sodium glucose cotransporters inhibitors in type 1 diabetes. Pharmacological Research 2018, 133, 1 - 8.

22.Dumont, C.;  Bourgeois, S.;  Fessi, H.; Jannin, V., Lipid-based nanosuspensions for oral delivery of peptides, a critical review. International Journal of Pharmaceutics 2018, 541 (1-2), 117 - 135.

23.Easa, N.;  Alany, R. G.;  Carew, M.; Vangala, A., A review of non-invasive insulin delivery systems for diabetes therapy in clinical trials over the past decade. Drug Discovery Today 2018.

24.Eilleia, S. Y.;  Soliman, M. E.;  Mansour, S.; S. Geneidi, A., Novel technique of insulin loading into porous carriers for oral delivery. Asian Journal of Pharmaceutical Sciences 2018, 13 (4), 297 - 309.

25.Eilleia, S. Y.;  Soliman, M. E.;  Niedermayer, S.;  Schmidt, A.;  Mansour, S.; Geneidi, A. S., Examining insulin adsorption onto mesoporous silica microparticles for oral delivery. Current Drug Delivery 2018, 15 (4), 541 - 553.

26.Fan, W.;  Xia, D.;  Zhu, Q.;  Li, X.;  He, S.;  Zhu, C.;  Guo, S.;  Hovgaard, L.;  Yang, M.; Gan, Y., Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials 2018, 151, 13 - 23.

27.Fuadah, N. R.; Hertadi, R., In Silico Study of Phospholipids as An Oral Insulin Delivery System. Journal of Physics: Conference Series 2018, 1090 (1).

28.Fukuoka, Y.;  Khafagy, E.-S.;  Goto, T.;  Kamei, N.;  Takayama, K.;  Peppas, N. A.; Takeda-Morishita, M., Combination strategy with complexation hydrogels and cell-penetrating peptides for oral delivery of insulin. Biological and Pharmaceutical Bulletin 2018, 41 (5), 811 - 814.

29.Gabbai, F. B., The role of renal response to amino acid infusion and oral protein load in normal kidneys and kidney with acute and chronic disease. Current Opinion in Nephrology and Hypertension 2018, 27 (1), 23 - 29.

30.Gedawy, A.;  Martinez, J.;  Al-Salami, H.; Dass, C. R., Oral insulin delivery: existing barriers and current counter-strategies. Journal of Pharmacy and Pharmacology 2018, 70 (2), 197 - 213.

31.Harris, K.;  Boland, C.;  Meade, L.; Battise, D., Adjunctive therapy for glucose control in patients with type 1 diabetes. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2018, 11, 159 - 173.

32.He, H.;  Lu, Y.;  Qi, J.;  Zhao, W.;  Dong, X.; Wu, W., Biomimetic thiamine- and niacin-decorated liposomes for enhanced oral delivery of insulin. Acta Pharmaceutica Sinica B 2018, 8 (1), 97 - 105.

33.He, Z.;  Liu, Z.;  Tian, H.;  Hu, Y.;  Liu, L.;  Leong, K. W.;  Mao, H.-Q.; Chen, Y., Scalable production of core-shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral delivery of insulin. Nanoscale 2018, 10 (7), 3307 - 3319.

34.Hu, Q.; Luo, Y., Recent advances of polysaccharide-based nanoparticles for oral insulin delivery. International Journal of Biological Macromolecules 2018, 120, 775 - 782.

35.Ibie;  Knott; Thompson, Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation?towards oral insulin delivery. Drug Development and Industrial Pharmacy 2018.

36.Ismail, H. M.;  Xu, P.;  Libman, I. M.;  Becker, D. J.;  Marks, J. B.;  Skyler, J. S.;  Palmer, J. P.; Sosenko, J. M., The shape of the glucose concentration curve during an oral glucose tolerance test predicts risk for type 1 diabetes. Diabetologia 2018, 61 (1), 84 - 92.

37.Jafary Omid, N.;  Bahari Javan, N.;  Dehpour, A.-R.;  Partoazar, A.;  Rafiee Tehrani, M.; Dorkoosh, F., In-vitro and in-vivo cytotoxicity and efficacy evaluation of novel glycyl-glycine and alanyl-alanine conjugates of chitosan and trimethyl chitosan nano-particles as carriers for oral insulin delivery. International Journal of Pharmaceutics 2018, 535 (1-2), 293 - 307.

38.Jung, S.-H.;  Jung, C.-H.;  Reaven, G. M.; Kim, S. H., Adapting to insulin resistance in obesity: role of insulin secretion and clearance. Diabetologia 2018, 61 (3), 681 - 687.

39.Kamei, N.;  Shigei, C.;  Hasegawa, R.; Takeda-Morishita, M., Exploration of the key factors for optimizing the in vivo oral delivery of insulin by using a noncovalent strategy with cell-penetrating peptides. Biological and Pharmaceutical Bulletin 2018, 41 (2), 239 - 246.

40.Kassem, M.;  Ali, A.; El-badrawy, A., Formulation, characterization and in-vivo application of oral insulin nanotechnology using different biodegradable polymers: Advanced drug delivery system. International Journal of Pharmaceutical Sciences and Research 2018, 9 (9), 3664 - 3677.

41.Kermanizadeh, A.;  Powell, L. G.;  Stone, V.; M?ller, P., Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: Current landscape. International Journal of Nanomedicine 2018, 13, 7575 - 7605.

42.Kesharwani, P.;  Gorain, B.;  Low, S. Y.;  Tan, S. A.;  Ling, E. C. S.;  Lim, Y. K.;  Chin, C. M.;  Lee, P. Y.;  Lee, C. M.;  Ooi, C. H.;  Choudhury, H.; Pandey, M., Nanotechnology based approaches for anti-diabetic drugs delivery. Diabetes Research and Clinical Practice 2018, 136, 52 - 77.

43.Kihl, P.;  Krych, L.;  Buschard, K.;  Wesley, J. D.;  Kot, W.;  Hansen, A. K.;  Nielsen, D. S.; von Herrath, M. G., Oral insulin does not alter gut microbiota composition of NOD mice. Diabetes/Metabolism Research and Reviews 2018, 34 (6).

44.Kou, L.;  Bhutia, Y. D.;  Yao, Q.;  He, Z.;  Sun, J.; Ganapathy, V., Transporter-guided delivery of nanoparticles to improve drug permeation across cellular barriers and drug exposure to selective cell types. Frontiers in Pharmacology 2018, 9 (JAN).

45.Kumar, V.;  Choudhry, I.;  Namdev, A.;  Mishra, S.;  Soni, S.;  Hurkat, P.;  Jain, A.; Jain, D., Oral insulin: Myth or reality. Current Diabetes Reviews 2018, 14 (6), 497 - 508.

46.Lamb, Y. N.; Syed, Y. Y., LY2963016 Insulin Glargine: A Review in Type 1 and 2 Diabetes. BioDrugs 2018, 32 (1), 91 - 98.

47.Li, C.;  Huang, F.;  Liu, Y.;  Lv, J.;  Wu, G.;  Liu, Y.;  Ma, R.;  An, Y.; Shi, L., Nitrilotriacetic Acid-Functionalized Glucose-Responsive Complex Micelles for the Efficient Encapsulation and Self-Regulated Release of Insulin. Langmuir 2018, 34 (40), 12116-12125.

48.Li, P.;  Hao, J.;  Li, H.;  Guan, H.; Li, C., Development of an enteric nanoparticle of marine sulfated polysaccharide propylene glycol alginate sodium sulfate for oral administration: formulation design, pharmacokinetics and efficacy. Journal of Pharmacy and Pharmacology 2018, 70 (6), 740 - 748.

49.Lin, P.-Y.;  Chiu, Y.-L.;  Huang, J.-H.;  Chuang, E.-Y.;  Mi, F.-L.;  Lin, K.-J.;  Juang, J.-H.;  Sung, H.-W.; Leong, K. W., Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy. Advanced Science 2018, 5 (8).

50.Liu, L.;  Zhang, Y.;  Yu, S.;  Yang, Z.;  He, C.; Chen, X., Dual Stimuli-Responsive Nanoparticle-Incorporated Hydrogels as an Oral Insulin Carrier for Intestine-Targeted Delivery and Enhanced Paracellular Permeation. ACS Biomaterials Science and Engineering 2018, 4 (8), 2889 - 2902.

51.Liu, L.;  Zhang, Y.;  Yu, S.;  Zhang, Z.;  He, C.; Chen, X., PH- and Amylase-Responsive Carboxymethyl Starch/Poly(2-isobutyl-acrylic acid) Hybrid Microgels as Effective Enteric Carriers for Oral Insulin Delivery. Biomacromolecules 2018, 19 (6), 2123 - 2136.

52.Liu, M.;  Wu, L.;  Shan, W.;  Cui, Y.; Huang, Y., Iron-mimic peptide converts transferrin from foe to friend for orally targeting insulin delivery. Journal of Materials Chemistry B 2018, 6 (4), 593 - 601.

53.Mahobia, S.;  Bajpai, J.; Bajpai, Soya protein as possible potential nanocarriers for in-vitro oral delivery of insulin in simulated gastric fluids (SGFs). International Journal of Polymeric Materials and Polymeric Biomaterials 2018, 67 (6), 340 - 350.

54.Marya;  Khan, H.;  Nabavi, S. M.; Habtemariam, S., Anti-diabetic potential of peptides: Future prospects as therapeutic agents. Life Sciences 2018, 193, 153 - 158.

55.McClements, D. J., Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review. Advances in Colloid and Interface Science 2018, 253, 1 - 22.

56.Meneguin, A. i. B.;  Beyssac, E.;  Garrait, G.;  Hsein, H.; Cury, B. S. F., Retrograded starch/pectin coated gellan gum-microparticles for oral administration of insulin: A technological platform for protection against enzymatic degradation and improvement of intestinal permeability. European Journal of Pharmaceutics and Biopharmaceutics 2018, 123, 84 - 94.

57.Moss, D. M.;  Curley, P.;  Kinvig, H.;  Hoskins, C.; Owen, A., The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery. Expert Review of Gastroenterology and Hepatology 2018, 12 (3), 223 - 236.

58.Nagy, C. r.; Einwallner, E., Study of in vivo glucose metabolism in high-fat diet-fed mice using oral glucose tolerance test (OGTT) and insulin tolerance test (ITT). Journal of Visualized Experiments 2018, 2018 (131).

59.Nielsen, L. H.;  Keller, S. S.; Boisen, A., Microfabricated devices for oral drug delivery. Lab on a Chip 2018, 18 (16), 2348 - 2358.

60.Nishikawa, T.;  Ono, K.;  Hashimoto, S.;  Kinoshita, H.;  Watanabe, T.;  Araki, H.;  Otsu, K.;  Sakamoto, W.;  Harada, M.;  Toyonaga, T.;  Kawakami, S.;  Fukuda, J.;  Haga, Y.;  Kukidome, D.;  Takahashi, T.; Araki, E., One-hour oral glucose tolerance test plasma glucose at gestational diabetes diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance. Journal of Diabetes Investigation 2018, 9 (6), 1370 - 1377.

61.Niu, Z.;  Samaridou, E.;  Jaumain, E.;  Co?ne, J.;  Ullio, G.;  Shrestha, N.;  Garcia, J.;  Dur?n-Lobato, M.;  Tovar, S.;  Santander-Ortega, M. J.;  Lozano, M. V.;  Arroyo-Jimenez, M. M.;  Ramos-Membrive, R. o.;  Pe?uelas, I. n.;  Mabondzo, A. s.;  Pr?at, V. r.;  Teixid, M.;  Giralt, E.; Alonso, M. a. J., PEG-PGA enveloped octaarginine-peptide nanocomplexes: An oral peptide delivery strategy. Journal of Controlled Release 2018, 276, 125 - 139.

62.Pandey, M.;  Choudhury, H.;  Yi, C. X.;  Mun, C. W.;  Phing, G. K.;  Rou, G. X.;  Singh, B. J. K. A. P. A. J.;  Jhee, A. N. A.;  Chin, L. K.;  Kesharwani, P.;  Gorain, B.; Hussain, Z., Recent updates on novel approaches in insulin drug delivery: A review of challenges and pharmaceutical implications. Current Drug Targets 2018, 19 (15), 1782 - 1800.

63.Pareek, M.;  Bhatt, D. L.;  Nielsen, M. L.;  Jagannathan, R.;  Eriksson, K.-F.;  Nilsson, P. M.;  Bergman, M.; Olsen, M. H., Enhanced predictive capability of a 1-hour oral glucose tolerance test: A prospective population-based cohort study. Diabetes Care 2018, 41 (1), 171 - 177.

64.Qi, X.;  Yuan, Y.;  Zhang, J.;  Bulte, J. W. M.; Dong, W., Oral Administration of Salecan-Based Hydrogels for Controlled Insulin Delivery. Journal of Agricultural and Food Chemistry 2018, 66 (40), 10479 - 10489.

65.Rehmani, S.; Dixon, J. E., Oral delivery of anti-diabetes therapeutics using cell penetrating and transcytosing peptide strategies. Peptides 2018, 100, 24 - 35.

66.Rosales-Mendoza, S.; Nieto-G?mez, R., Green Therapeutic Biocapsules: Using Plant Cells to Orally Deliver Biopharmaceuticals. Trends in Biotechnology 2018, 36 (10), 1054 - 1067.

67.Schultz, W. M.;  Varghese, T.;  Heinl, R. E.;  Dhindsa, D. S.;  Mahlof, E. N.;  Cai, H. C.;  Southmayd, G.;  Sandesara, P. B.;  Eapen, D. J.; Sperling, L. S., Natural approaches in diabetes management: A review of diet, exercise, and natural products. Current Pharmaceutical Design 2018, 24 (1), 84 - 98.

68.Sgorla, D. b.;  Lechanteur, A.;  Almeida, A.;  Sousa, F. v.;  Melo, E.;  Bunhak, l.;  Mainardes, R.;  Khalil, N.;  Cavalcanti, O.; Sarmento, B., Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery. Expert Opinion on Drug Delivery 2018, 15 (3), 213 - 222.

69.Shamsa, E. S.;  Mahjub, R.;  Mansoorpour, M.;  Rafiee-Tehrani, M.; Dorkoosh, F. A., Nanoparticles prepared from N,N-Dimethyl-N-Octyl chitosan as the novel approach for oral delivery of insulin: Preparation, statistical optimization and in-vitro characterization. Iranian Journal of Pharmaceutical Research 2018, 17 (2), 442 - 459.

70.Song, M.;  Wang, H.;  Chen, K.;  Zhang, S.;  Yu, L.;  Elshazly, E. H.;  Ke, L.; Gong, R., Oral insulin delivery by carboxymethyl-beta-cyclodextrin-grafted chitosan nanoparticles for improving diabetic treatment. Artificial Cells, Nanomedicine and Biotechnology 2018.

71.Sun, Q.;  Zhang, Z.;  Zhang, R.;  Gao, R.; McClements, D. J., Development of Functional or Medical Foods for Oral Administration of Insulin for Diabetes Treatment: Gastroprotective Edible Microgels. Journal of Agricultural and Food Chemistry 2018, 66 (19), 4820 - 4826.

72.Tan, X.;  Liu, X.;  Zhang, Y.;  Zhang, H.;  Lin, X.;  Pu, C.;  Gou, J.;  He, H.;  Yin, T.;  Zhang, Y.; Tang, X., Silica nanoparticles on the oral delivery of insulin. Expert Opinion on Drug Delivery 2018, 15 (8), 805 - 820.

73.Thwala, L. N.;  Delgado, D. P.;  Leone, K.;  Marigo, I.;  Benetti, F.;  Chenlo, M.;  Alvarez, C. V.;  Tovar, S.;  Dieguez, C.;  Csaba, N. S.; Alonso, M. J., Protamine nanocapsules as carriers for oral peptide delivery. Journal of Controlled Release 2018, 291, 157 - 168.

74.Tian, H.;  He, Z.;  Sun, C.;  Yang, C.;  Zhao, P.;  Liu, L.;  Leong, K. W.;  Mao, H.-Q.;  Liu, Z.; Chen, Y., Uniform Core?Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin. Advanced Healthcare Materials 2018, 7 (17).

75.Tyagi, P.;  Pechenov, S.; Anand, S., Oral peptide delivery: Translational challenges due to physiological effects. Journal of Controlled Release 2018, 287, 167 - 176.

76.Villaverde Cendon, F.;  Matos Jorge, R. M.;  Weinschutz, R.; Mathias, A. L., Effect of matrix composition, sphere size and hormone concentration on diffusion coefficient of insulin for controlled gastrointestinal delivery for diabetes treatment. Journal of Microencapsulation 2018, 35 (1), 13 - 25.

77.Wang, A.;  Yang, T.;  Fan, W.;  Yang, Y.;  Zhu, Q.;  Guo, S.;  Zhu, C.;  Yuan, Y.;  Zhang, T.; Gan, Y., Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers. Advanced Healthcare Materials 2018.

78.Wang, X.;  Cheng, D.;  Liu, L.; Li, X., Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery. Pharmaceutical Development and Technology 2018, 23 (4), 351 - 357.

79.Wong, C. Y.;  Al-Salami, H.; Dass, C. R., Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin. International Journal of Pharmaceutics 2018, 537 (1-2), 223 - 244.

80.Wong, C. Y.;  Al-Salami, H.; Dass, C. R., Recent advancements in oral administration of insulin-loaded liposomal drug delivery systems for diabetes mellitus. International Journal of Pharmaceutics 2018, 549 (1-2), 201 - 217.

81.Wu, J.;  Zheng, Y.;  Liu, M.;  Shan, W.;  Zhang, Z.; Huang, Y., Biomimetic Viruslike and Charge Reversible Nanoparticles to Sequentially Overcome Mucus and Epithelial Barriers for Oral Insulin Delivery. ACS Applied Materials and Interfaces 2018, 10 (12), 9916 - 9928.

82.Xing, X.;  Zhao, X.;  Ding, J.;  Liu, D.; Qi, G., Enteric-coated insulin microparticles delivered by lipopeptides of iturin and surfactin. Drug Delivery 2018, 25 (1), 23 - 34.

83.Xu, Y.;  Zheng, Y.;  Wu, L.;  Zhu, X.;  Zhang, Z.; Huang, Y., Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin. ACS Applied Materials and Interfaces 2018, 10 (11), 9315 - 9324.

84.Yu, J.;  Zhang, Y.;  Wang, J.;  Wen, D.;  Kahkoska, A. R.;  Buse, J. B.; Gu, Z., Glucose-responsive oral insulin delivery for postprandial glycemic regulation. Nano Research 2018.

85.Zhang, H.;  Wang, W.;  Li, H.;  Peng, Y.; Zhang, Z., Microspheres for the oral delivery of insulin: preparation, evaluation and hypoglycaemic effect in streptozotocin-induced diabetic rats. Drug Development and Industrial Pharmacy 2018, 44 (1), 109 - 115.

86.Zhang, L.;  Qin, H.;  Li, J.;  Qiu, J.-N.;  Huang, J.-M.;  Li, M.-C.; Guan, Y.-Q., Preparation and characterization of layer-by-layer hypoglycemic nanoparticles with pH-sensitivity for oral insulin delivery. Journal of Materials Chemistry B 2018, 6 (45), 7451 - 7461.

87.Zhang, Y.;  Zhang, L.;  Ban, Q.;  Li, J.;  Li, C.-H.; Guan, Y.-Q., Preparation and characterization of hydroxyapatite nanoparticles carrying insulin and gallic acid for insulin oral delivery. Nanomedicine: Nanotechnology, Biology, and Medicine 2018, 14 (2), 353 - 364.

88.Zheng, Y.;  Wu, J.;  Shan, W.;  Wu, L.;  Zhou, R.;  Liu, M.;  Cui, Y.;  Zhou, M.;  Zhang, Z.; Huang, Y., Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway. ACS Applied Materials and Interfaces 2018.

89.Zhuravlyeva, N. N.; Krasnoshtanova, A. A. b., Development of the chitosan-alginate microparticle based system for the delivery of insulin. Russian Journal of Biopharmaceuticals 2018, 10 (5), 15 - 20.

90.Ziegler;  Ohli;  Hoefs;  Aydin;  Falk; Gross, Early detection and primary prevention of type?1 diabetes: Global Platform for the Prevention of Autoimmune Diabetes (GP?PAD). Diabetologe 2018, 14 (4), 240 - 244.

91.CROSS-LINKED MALTODEXTRINS FOR THE ORAL DELIVERY OF BIOLOGICAL ACTIVES. EP3427725, 2019.

92.Abramson, A.;  Caffarel-Salvador, E.;  Khang, M.;  Dellal, D.;  Silverstein, D.;  Gao, Y.;  Frederiksen, M. R.;  Vegge, A.;  Hubálek, F.;  Water, J. J.;  Friderichsen, A. V.;  Fels, J.;  Kirk, R. K.;  Cleveland, C.;  Collins, J.;  Tamang, S.;  Hayward, A.;  Landh, T.;  Buckley, S. T.;  Roxhed, N.;  Rahbek, U.;  Langer, R.; Traverso, G., An ingestible self-orienting system for oral delivery of macromolecules. Science Translational Medicine  2019, 363 (6427), 611-615.

93.Boushra, M.;  Tous, S.;  Fetih, G.;  Xue, H.-Y.; Wong, H.-L., Development of bi-polymer lipid hybrid nanocarrier (BLN) to improve the entrapment and stability of insulin for efficient oral delivery. Journal of Drug Delivery Science and Technology 2019, 49, 632 - 641.

94.Kuipers, A.;  Moll, G. N.;  Wagner, E.; Franklin, R., Efficacy of lanthionine-stabilized angiotensin-(1-7) in type I and type II diabetes mouse models. Peptides 2019, 112, 78 - 84.

95.Liu, C.;  Kou, Y.;  Zhang, X.;  Dong, W.;  Cheng, H.; Mao, S., Enhanced oral insulin delivery via surface hydrophilic modification of chitosan copolymer based self-assembly polyelectrolyte nanocomplex. International Journal of Pharmaceutics 2019, 554, 36 - 47.

96.Mart?nez, L. p.;  Carvajal, M.;  Sotelo, C.;  Micard;  Rasc?n, C.;  Franco, L. p.;  Lizardi, M.; Canett, R., Enzymatically cross-linked arabinoxylan microspheres as oral insulin delivery system. International Journal of Biological Macromolecules 2019, 126, 952 - 959.

97.Sun, L.;  Liu, Z.;  Tian, H.;  Le, Z.;  Liu, L.;  Leong, K. W.;  Mao, H.-Q.; Chen, Y., Scalable Manufacturing of Enteric Encapsulation Systems for Site-Specific Oral Insulin Delivery. Biomacromolecules 2019, 20 (1), 528 - 538.

98.Tan, S. Y.;  Mei Wong, J. L.;  Sim, Y. J.;  Wong, S. S.;  Mohamed Elhassan, S. A.;  Tan, S. H.;  Ling Lim, G. P.;  Rong Tay, N. W.;  Annan, N. C.;  Bhattamisra, S. K.; Candasamy, M., Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention. Diabetes and Metabolic Syndrome: Clinical Research and Reviews 2019, 13 (1), 364 - 372.

99.Tsai, L.-C.;  Chen, C.-H.;  Lin, C.-W.;  Ho, Y.-C.; Mi, F.-L., Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin. International Journal of Biological Macromolecules 2019, 126, 141 - 150.

100.Vasconcelos Silva, E. d. L.;  Oliveira, A. n. C. d. J.;  Patriota, Y. B. l. G.;  Ribeiro, A. n. J.;  Veiga, F.;  Hallwass, F.;  Silva-Filho, E. C.;  da Silva, D. A.;  Soares, M. F. d. L. R.;  Wanderley, A. G. a.; Soares-Sobrinho, J. L., Solvent-free synthesis of acetylated cashew gum for oral delivery system of insulin. Carbohydrate Polymers 2019, 207, 601 - 608.




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