NIH Roadmap计划定位引用Science的评述“The NIH Roadmap is a set of bold initiatives aimed ataccelerating medical research. These initiatives will address challenges that no single NIH institute could tackle alone, but the agency as a whole must undertake. The Roadmap identifies the most compelling opportunities in three arenas: new pathways to discovery, research teams of the future, and reengineering the clinical research enterprise.”(Zerhouni E. Medicine. The NIH Roadmap. Science. 2003 Oct3;302(5642):63-72.).

2014年NIH Roadmap引入新的领域值得我们关注，将代表医学前沿研究的发展方向：

1. Glycoscience（糖科学）is the study of howthe addition of sugar modifications to proteins change the way the proteins function in important ways. The complexity of carbohydrate chemistry makes theanalysis of these sugar modifications inaccessible to most biomedicalresearchers. The Glycoscience program will develop methodologies and resourcesto make the study of sugar modifications more accessible to the broadbiomedical research community.

2. The 4D Nucleome program （4D核小体） will develop technologies to enable the study of how DNA is arranged within cells in spaceand time (the fourth dimension) and how this affects cellular function inhealth and disease. Recent scientific advances, coupled with technological breakthroughs in tools and methods, provide the opportunity to catalyze thisemerging field of research. 4D nucleome science aims to understand theprinciples behind the organization of the nucleus in space and time, the rolethat the arrangement of DNA plays in gene expression and cellular function, andhow changes in nuclear organization affect health and disease.

3. The Stimulating Peripheral Activity to Relieve Conditions (SPARC) program （外周神经刺激治疗）will develop high resolution neural circuit maps and next generation neural modulation devices –implants that can stimulate nerves – and will demonstrate the use of these tools in the development of new therapeutic strategies. All organs arestimulated by nerves, which send signals that affect the organ’s function.Modulation of nerve signals to control organ function has therefore beenrecognized as a potentially powerful way to treat many diseases and conditions,such as hypertension, heart failure, gastrointestinal disorders, type II diabetes, and inflammatory disorders.

信息来源：http://commonfund.nih.gov/ 

附：NIH Roadmap CommonFund Programs

（文/严舒  贾晓峰）