I was also getting the error 1325 when trying to uninstall ArcGIS Desktop 10.3.1. The fix was to remove a couple of CD/DVD (virtual) drives from the system.
博文
解决Error 1325. EsriPyFldr is not a valid short file name
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解决"Error 1325. EsriPyFldr is not a valid short file name."
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去尝试各种卸载办法（甚至求助esri）之前，也许应该看看是不是电脑盘符的变化让esri感觉你盗版了，呵呵。
https://blog.sciencenet.cn/blog-73355-1011195.html
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