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河北科大已经从诺维信拿到了第一笔支付,而且如果诺维信使用 NgAgo 技术,学校还能分成(The company said that it had made an undisclosed upfront payment to the Hebei University of Science and Technology in Shijiazhuang to use NgAgo. It also says that the university will receive royalties if Novozymes uses the technology in developing a commercial product.)。可以说,韩氏 NgAgo 已经产生经济效益了。
韩国人 Jin Soo Kim 的这篇发现韩氏 NgAgo + gDNA 剪切 RNA的论文发表之后,BURGIO 在推特兴高采烈地说这下 韩春雨还得从韩国人那获得授权。注意,JIN SOO KIM 就是之前 NBT 上发文质疑韩春雨的那位 (参见 http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3753.html ),也是CRISPR方面的专家。可见,虽然 KIM 之前不能重复韩春雨的实验,但仍然没有放弃。说明这很重要。
“Has someone spotted the irony that if Han & @Novozymes wish to develop #NgAgo as RNAi tool they would have to license to Jin Soo Kim” (“有人注意到这个讽刺性问题没?如果韩春雨跟诺维信想把 NgAgo 发展成 RNA 干扰工具,他们还得从韩国人金那获得许可”)(译注:BURGIO后面这个 license to 应该是 license from,才能自洽)
我回应了句:“No! One can't patent a natural process. NgAgo editing is a naturally occurring mechanism.” (
(“不对!你不能把自然过程申请专利。NgAgo 编辑是自然发生的机制。”)
另外,BURGIO 称 类似 AGO的RNA编辑功能,DOUDNA早就发现了(2014)。
Gaetan Burgio @GaetanBurgio 6h6 hours ago Very similar finding to Doudna lab paper an another procaryotic Ago @PNASNews http://www.pnas.org/content/113/15/4057.full …
我回应到:【@GaetanBurgio You are missing the crucial point. The temperature it operates. Doudna's was at 60 C.】(您不得要领啊。注意工作温度。道德娜的是60摄氏度)
《自然》网站发布了韩春雨与诺维信合作的消息。网址
http://www.nature.com/news/enzyme-firm-invests-in-ngago-protein-at-centre-of-gene-editing-row-1.21343
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