Nature neurosci—坏死性凋亡的激活参与阿尔茨海默病的发生

Summary

1.Increase in necroptosis markers in AD human brains.

2. Necrosome formation in AD.

3. Necroptosis activation is linked to reduced brain weight.

4. The activation of RIPK1 and MLKL correlates with Braak stage.

5. Regulation of AD transcriptome and risk-associated genes by RIPK1.

6. Necroptosis activation exacerbates cognitive deficits in APP/PS1 mice.

7. Constitutively active MLKL induces a higher degree of neuronal death in APP/PS1 than NonTg mice.

8. Necroptosis contributes to neuronal death in 5xFAD mice.