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Science—研究表明早期人生应激事件可能会增加成年后抑郁症易感性
Science—研究表明早期人生应激事件可能会增加成年后抑郁症易感性
1.Early life stress enhances susceptibility to depression-like behavior.
2.RNA-seq reveals long-lasting transcriptional alterations in VTA that predict OTX2 as an upstream regulator.
3.Otx2 expression in VTA bidirectionally controls depression-like behavior.
4.Late postnatal stress transiently alters OTX2 binding at target genes.
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