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JCI——神经元缝隙连接是青光眼的潜在治疗靶点
Abstract
1.Blockade of GJs suppresses gross retinal injury in glaucomatous eyes.
2.Reactive gliosis in retinas of microbead-injected mice is significantly reduced by GJ blockade/ablation.
3.Blockade or ablation of GJs protects RGCs and their axons in experimental glaucoma.
4.GJ blockade or ablation protects ACs in glaucomatous eyes.
5.Expression of Cx36 is upregulated in experimental glaucoma.
6.Ablation of neuronal Cx36 protects the optic nerve in experimental glaucoma.
7.Blockade of neuronal gap junctions preserves retina and optic nerve function in glaucoma.
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