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Nature neurosci——臂旁核的CGRP神经元介导了癌症诱导的厌食和劳累症状
Abstract
1.CGRPPBN neurons are pathologically active in tumor-bearing mice.
2.Inactivation of CGRPPBN neurons prevents cancer anorexia.
3.Established cancer anorexia is reversed with chemogenetic inhibition of CGRPPBN neurons.
4.Role of CGRPPBN neurons in cancer-induced cachexia and increased energy expenditure.
5.Inactivation of CGRPPBN neurons permits hyperphagia in nonanorexic Apcmin/+ genetic cancer model.
6.Inactivation of CGRPPBN neurons permits hyperphagia in nonanorexic Apcmin/+ genetic cancer model.
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