STM——补体C3缺陷可以预防APP/PS1小鼠发生神经变性

Abstract

1.APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age

2.Increased Ab plaque load in 16-month-old APP/PS1;C3 KO mice.

3.Morphological changes associated with glial activation
were reduced in 16-month-old APP/PS1;C3KO mice.

4.Plaque-associated microglia and astrocytes and brain cytokines were altered in APP/PS1;C3 KO mice compared to APP/PS1 mice.

5.C3 deficiency resulted in partial preservation of synapse density in APP/PS1 mice despite an increased plaque load.

6.C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice