Nature——乙酰CoA调控组蛋白乙酰化和海马记忆功能

Abstract

1.Nuclear ACSS2 supports neuronal gene expression.

2.ACSS2 is recruited to transcriptionally active chromatin and promotes neuronal histone acetylation.

3.ACSS2 ChIP–seq localization is linked to histone
acetylation in vivo in mouse hippocampus.

4.ACSS2 knockdown in dorsal hippocampus impairs object location memory and upregulation of immediate early genes following training.