Neuron—— 慢性阻断CA2神经传递导致海马高兴奋性

1.CA2 Output Recruits Inhibition in CA3 and Filters Network Excitability

2.CA2-PC-Specific Expression of TeTX Silences Synaptic Transmission and Increases CA3 Recurrent Excitability

3.Silencing CA2 PCs Leads to Transient Increases in LFP Power with Properties Similar to Place Fields

4.Changes in PC Spiking Following Chronic CA2 Silencing

5.Acute CA2-PC Inhibition Alters the Spatial Distribution of Ensemble Spiking

6.Normal Ripple Events are Replaced with Epileptiform-like Discharges Following CA2 Silencing

7.Chronic CA2 Silencing Slows Contextual Learning and Increases Seizure Susceptibility