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Neuron——研究证明Hub对于记忆的形成起到关键作用

已有 2141 次阅读 2017-4-30 16:25 |个人分类:神经科学临床和基础|系统分类:观点评述| style

Neuron——研究证明Hub对于记忆的形成起到关键作用

在网络理论中，与其他node之间的连接较多的node被称为hub。Hub被认为是网络中的关键枢纽，一旦hub被破坏，网络的稳定性将显著下降。尽管在神经科学中，hub也被认为与神经系统功能相关，但是是否Hub与记忆之间存在因果关联却不得而知。最近科学家采用药理遗传学方法证明了把某些网络中的关键hub沉默之后，可以显著的影响记忆的表达。以下是摘要：
Behavior depends on coordinated activity across multiple brain regions. Within such networks, highly connected hub regions are assumed to disproportionately influence behavioral output, although this hypothesis has not been systematically evaluated. Previously, by mapping brain-wide expression of the activity-regulated gene c-fos, we identified a network of brain regions co-activated by fear memory. To test the hypothesis that hub regions are more important for network function, here, we simulated node deletion in silico in this behaviorally defined functional network. Removal of high degree nodes produced the greatest network disruption (e.g., reduction in global efficiency). To test these predictions in vivo, we examined the impact of post-training chemogenetic silencing of different network nodes on fear memory consolidation. In a series of independent experiments encompassing 25% of network nodes (i.e., 21/84 brain regions),we found that node degree accurately predicted observed deficits in memory consolidation, with silencing of highly connected hubs producing the largest impairments.