Curcumin is the major compound in the Tumeric and have a protective action in the neurodegenarative disease, for example, Alzheimer's Disease. But the lower bioactivity is problem about it. To increse the bioactivity is the best challege for researchers. So, to change the structure may have a good result. It is possiblet that the changed cucumin will lose it's protective role or gain a new action. Cetainly, time will tell us the truth.