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2017年12月18日Molecular Plant在线文章,该文章为复旦大学杨洪全课题组完成,文章揭示了光信号和生长素信号的拮抗作用,调节拟南芥下胚轴的伸长。CRY1和phyB受光激活,它们与TIR1竞争性的与AUX/IAAs的相互作用,从而稳定AUX/IAAs不被降解,进而抑制生长素的信号。
原题目为:
Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis
摘要:
光是一种关键的环境信号,通过拟南芥中的蓝光和红光/远红光受体隐花色素和光敏色素介导的途径来抑制下胚轴细胞伸长。生长素是关键的植物激素,其通过生长素受体TIR1/AFBs介导的AUX/IAA蛋白的降解来促进下胚轴伸长。这种拮抗作用的机制尚不清楚。这里,我们的研究表明,光可以通过稳定AUX/IAAs来抑制生长素信号,这种作用分别是通过蓝光和红光依赖的CRY1和phyB与AUX/IAAs的相互作用所实现的。蓝光触发CRY1与AUX/IAAs的相互作用,从而抑制TIR1与AUX/IAA的结合,导致生长素诱导的这些蛋白的降解被抑制。我们的结果表明光受体与生长素受体共享AUX/IAA蛋白作为相同的直接下游信号组件。通过光受体和生长素受体对AUX/IAA蛋白质稳定性的拮抗调节,允许植物平衡光和生长素信号,进而优化其生长。
Abstract:
Light is a key environmental cue that acts to inhibit hypocotyl cell elongation through the blue and red/far-red light photoreceptors cryptochrome- and phytochrome-mediated pathways in Arabidopsis. Auxin is a pivotal phytohormone that acts to promote hypocotyl elongation through the auxin receptors TIR1/AFBs-mediated degradation of AUX/IAA proteins (AUX/IAAs). The mechanism underlying this antagonistic interaction is unclear. Here we show that light inhibits auxin signaling through stabilization of AUX/IAAs by blue and red light-dependent interactions of cryptochrome 1 (CRY1) and phytochrome B with AUX/IAAs, respectively. Blue light-triggered interactions of CRY1 with AUX/IAAs inhibit the associations of TIR1 with AUX/IAAs, leading to repression of auxin-induced degradation of these proteins. Our results indicate that photoreceptors share AUX/IAA proteins with auxin receptors as the same direct downstream signaling components. We propose that antagonistic regulation of AUX/IAA protein stability by photoreceptor and auxin receptor allows plants to balance light and auxin signals to optimize their growth.
光通过CRY1和phyB抑制生长素信号模型
在黑暗中,CRY1是失活的,而phyB以Pr的形式定位于细胞质。因为无法与AUX/IAA蛋白(A和C)相互作用,他们不能够调节生长素信号;在有光的条件下,CRY1被激活,phyB经历Pr到Pfr构象变化并且进入细胞核,并且它们可以与TIR1竞争与AUX/IAA蛋白质相互作用,从而抑制其降解,从而抑制ARF活性和生长素信号。
每日一词
pivotal
英[ˈpɪvətl]
美[ˈpɪvətl]
adj. 关键的; 中枢的; 枢轴的;
[例句]The Court of Appeal has a pivotal role in the English legal system
上诉法院在英格兰司法体系中起着中心作用。
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