An Inherently Bifunctional Subset of Foxp3⁺ T Helper Cells Is Controlled by the Transcription Factor Eos

• Highlights

• A subset of Treg cells shows labile expression of the corepressor Eos

• These Treg cells can reprogram into helper cells without losing Foxp3

• Eos-labile Treg cells are constitutively present in thymus, lymph nodes, and spleen

• Reprogrammed Treg cells can help support priming of effector T cells to new antigen