The molecular mechanism of HOTAIR in tumorigenesis, metastasis, and drug resistance

Xiaolong Zhou,  Jin Chen and  Wenru Tang

Acta Biochim Biophys Sin (Shanghai). 2014 Dec;46(12):1011-5. doi: 10.1093/abbs/gmu104

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650504, China Faculty of Medicine, Kunming University of Science and Technology, Kunming 650504, China

Long non-coding RNAs have been reported to play an important role in cellular metabolism and development. Homeobox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA, is pervasively over-expressed in most human cancers compared with non-cancerous adjacent tissues. Although many articles have reported that HOTAIR is closely associated with metastasis, epithelial-mesenchymal transition, advanced pathological stage, drugresistance, and poor prognosis, the role of HOTAIR in gene regulation and tumor development is largely unknown, and the potential molecular mechanisms are not completely clear yet. In this review, we summarized the recent progress in the study of the major functions of HOTAIR. miR-331-3p, miR-130a, miR-7, miR-141, HER2, c-MYC, WIF-1, RBM38, PTEN, and Col-1 are involved in the HOTAIR regulation network. We tried to elucidate the molecular mechanisms of HOTAIR in the aspects of tumorigenesis, metastasis, drugresistance, and regulation.

图例: HOTAIR信号通路

全文: http://abbs.oxfordjournals.org/content/46/12/1011.full