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ABBS: miR-193b modulates non-small cell lung cancer cells
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MicroRNA-193b modulates proliferation, migration, and invasion of non-small cell lung cancer cells
Huajun Hu, Shangao Li, Jun Liu, and Bin Ni
College of Life Science, China Jiliang University, Hangzhou 310018, China
MicroRNAs have been reported to be closely related to the development of human lung cancers. However, the functions of microRNAs in non-small cell lung cancer (NSCLC) remain largely undefined. Here, we investigated the role of microRNA-193b (miR-193b) in NSCLC. Our data showed that miR-193b was markedly down-regulated in NSCLC cancer tissues compared with adjacent normal tissues. The NSCLC cell line (A549) transfected with the miR-193b exhibited significantly decreased proliferation, migration, and invasion capacities when compared with the control cells. In contrast, inhibition of miR-193b increased the proliferation, migration, and invasion of A549 cells. Moreover, miR-193b repressed the expressions of cyclin D1 and urokinase-type plasminogen activator in A549 cells. These data suggest that miR-193b is a tumor suppressor in NSCLC.
图例: miR-193b抑制CNND1和uPA的表达
Acta Biochim Biophys Sin. 2012 May;44(5):424-430. doi: 10.1093/abbs/gms018
全文: http://abbs.oxfordjournals.org/content/44/5/424.full
引用本文的文献:
https://blog.sciencenet.cn/blog-592748-844615.html
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