胆固醇调节元件结合蛋白（SREBPs）是很重要的转录因子,主要调控胆固醇，脂肪酸和甘油三酯的生物合成。因此SREBPs对很多参与脂肪合成和摄取的关键基因的表达水平有决定性的作用。在这篇综述中，我们总结了胰岛素、cAMP和维生素A对SREBPs的影响，以及miRNA与脂质代谢的关系等方面的进展，以及最近几年一些在SREBPs蛋白质功能方面的研究。这些研究的结果提示通过抑制SREBPs治疗各种代谢疾病是一种新思路，如II型糖尿病，胰岛素抵抗、脂肪肝和动脉粥样硬化等。

图例1：SREBPs循环

图例2：胰岛素对SREBPs信号途径的影响

SREBP: a novel therapeutic target

Xu Xiao and Bao-Liang Song

Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shangha, China.

Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the biosynthesis of cholesterol, fatty acid, and triglyceride. They control the expression of crucial genes involved in lipogenesis and uptake. In this review, we summarize the processing of SREBPs and their regulation by insulin, cAMP, and vitamin A, and the relationship between miRNA and lipid metabolism. We also discuss the recent functional studies on SREBPs. These discoveries suggest that inhibition of SREBP can be a novel strategy to treat metabolic diseases, such as type II diabetes, insulin resistance, fatty liver, and atherosclerosis.

Acta Biochim Biophys Sin (Shanghai). 2013 Jan;45(1):2-10. doi: 10.1093/abbs/gms112.

全文: http://abbs.oxfordjournals.org/content/45/1/2.full.pdf+html