|||
Jingwei Zhao and Liming Cheng
Department of Orthopaedics, Tongji Hospital, School of Medicine Tongji University, Shanghai 200065, China
Acta Biochim Biophys Sin 2017, 49: 503–512; doi: 10.1093/abbs/gmx041
Osteosarcoma is the most frequent type of malignant primary bone tumor. Although many efforts have been made, the survival rate of osteosarcoma still remains unsatisfied. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with many diseases including tumors, and involved in the regulation of a wide array of pathophysiological processes. Colon-cancer-associated transcript-1 (CCAT1) was first identified in colon cancer and has subsequently been reported to perform many functions in tumor progression. The present study aimed to comprehensively explore the biological functions of CCAT1 and its underlying mechanism in osteosarcoma cells. Our findings revealed that CCAT1 was upregulated in osteosarcoma tissues and cells, and was involved in the proliferation and migration of osteosarcoma via regulating miR-148a/phosphatidyl inositol 3-kinase interacting protein 1 (PIK3IP1) signal pathway.
High level of CCAT1 regulates osteosarcoma cell proliferation and migration/invasion
阅读原文: http://www.abbs.org.cn/arts.asp?id=4163
获取全文: abbs@sibs.ac.cn
相关论文:
1 Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
2 CRISPR/Cas9 Knockout Strategies to Ablate CCAT1 lncRNA Gene in Cancer Cells
5 The lncRNA CCAT1 Upregulates Proliferation and Invasion in Melanoma Cells via Suppressing miR-33a
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-11-25 04:32
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社