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Cover story
Spinal cord injury(SCI) triggers a cascade of pathological events that lead to permanent loss ofconnections between proximal and distal neurons. Neurons and glial cells, suchas astrocytes, oligodendrocytes and immune cells, can all respond to injurysignals by changing their cellular behaviors and associated transcriptionalprofiles. One emerging concept for the lack of axon regeneration following SCIis that chromatin landscapes in neurons and glial cells become unfavorable fortissue repair and regeneration. Hence, insights into how chromatin landscapescan be reshaped in favor of repair and regeneration would enlighten us on howto harness epigenetic modulation to enhance recovery after SCI.
In thisissue (pages 356-366), Wong and Zou review recent advances in ourunderstanding of nuclear epigenetic events that can enhance axon growthpotential by promoting the expression of regeneration-associated genes (RAGs)ininjured neurons. In addition, using SCI-induced pathological events as aframework, Wong and Zou highlight how wound-healing properties of glial cells includingastrocytes, oligodendrocytes, as well as immune cells can also be influenced byepigenetic regulation. This review thus provides an integrated viewpoint andinsights into future directions of utilizing epigenetic tools to reshape the chromatinlandscapes to promote recovery after SCI.(See pages 356-366 by Jamie K. Wong and Hongyan Zoufor more information)
Contents
Volume 9 issue 5
Reviews
Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems
The correlation between iron homeostasis and telomere maintenance
Reshaping the chromatin landscape after spinal cord injury
Jamie K. WONG1,Hongyan ZOU1,2,*()
Regulation and function of stimulus-induced phosphorylation of MeCP2
Hongda LI1,2,Qiang CHANG1,2,3,*()
The role of Nkx3.2 in chondrogenesis
Roshni S. RAINBOW1,Heenam KWON2,Li ZENG1,2,3,*()
dsRNA binding protein PACT/RAX in gene silencing, development and diseases
Yue YONG1,Jia LUO2,*(),Zun-Ji KE1,3,*()
RNA-binding proteins in pluripotency, differentiation, and reprogramming
Diana GUALLAR1,2,Jianlong WANG1,2,3,*()
Research article
Computational screening of disease associated mutations on NPC1 gene and its structural consequence in Niemann-Pick type-C1
Naresh KANDAKATLA1,*(),Geetha RAMAKRISHNAN1,Rajasekhar CHEKKARA1,Namachivayam BALAKRISHNAN2
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