博文

2023年7月嘲风作品集（三）

已有 1054 次阅读 2023-9-28 11:08 |个人分类:作品发表|系统分类:论文交流

▲ Vol 08 Issue 14 | 24 July , 2023

Non-Invasive Touch-Based Lithium Monitoring Using an Organohydrogel-Based Sensing Interface

Shuyu Lin, Jialun Zhu, Justin Yeung, Tsung-Yu Wu, Xuanbing Cheng, Yichao Zhao, Bo Wang, Jiawei Tan, Sophie Peeters, Ariel Seroussi, Sriram Sankararaman, Carlos Milla, Sam Emaminejad

Ion-Selective Biosensors
In article 2202141, Sam Emaminejad and co-workers develop a touch-based noninvasive system to monitor lithium-based pharmacotherapy. It utilizes a thin organohydrogel lithium ion-selective electrode (TOH-ISE) that has dehydration-resistant properties, minimizing signal drift, and allowing for sweat collection. The system is successfully validated on a patient under lithium-based therapy, demonstrating its potential for lithium adherence monitoring and broad pharmacotherapy management.

https://onlinelibrary.wiley.com/doi/10.1002/admt.202370063

▲ Vol 95 Issue 29 | 25 July , 2023

In Situ Characterization of Bioaerosols at the Single-Particle Level Using Single-Particle Mass Spectrometry: A Promising Tool for Defending Human Health against Bioaerosol Transmission

Lei Li, Anthony S. Wexler, Xue Li, Ligang Hu, and Guibin Jiang

Bioaerosol transmission is one of the important transmission pathways of COVID-19 and other infectious respiratory diseases caused by viral infection. The ability to detect bioaerosols and characterize encapsulated pathogens both in situ and in real time is crucial for early warning and monitoring of the progress of an epidemic or pandemic. The lack of a powerful analytical tool for distinguishing between bioaerosols and nonbioaerosols as well as for identification of pathogen species contained in the bioaerosols is the bottleneck in related fields. Herein, a promising solution for in situ and real-time accurate and sensitive detection of bioaeorosols is proposed by integrating single-particle aerosol mass spectrometry, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and fluorescence spectroscopy. The proposed mass spectrometry aims at detecting bioaerosols in a range of 0.5–10 μm with adequate sensitivity and specificity. This single-particle bioaerosol mass spectrometry would not only be a powerful tool that can be useful for the authorities and public health monitoring but also would be an example of advances in mass spectrometry.

https://pubs.acs.org/doi/10.1021/acs.analchem.2c05324

▲ Vol 33 Issue 30 | 25 July , 2023

All-Organic Smart Textile Sensor for Deep-Learning-Assisted Multimodal Sensing

Pengfei Zhao, Yilin Song, Peng Xie, Fan Zhang, Tao Xie, Gang Liu, Jiyu Zhao, Su-Ting Han, Ye Zhou

Electronic Textiles
In article number 2301816, Ye Zhou and co-workers report an all-textile, all-organic, washable and breathable sensor to realize wide-range sensing of human activities and noncontact stimuli without sacrificing biocompatibility and comfortability. Additionally, by combining with the deep-learning technique, an all-textile sensing system is established to recognize object shape, contactless trajectory and environmental temperature.

https://onlinelibrary.wiley.com/doi/10.1002/adfm.202370186

▲ Vol 17 Issue 14 | 25 July , 2023

Liquid Metal Nanoplatform Based Autologous Cancer Vaccines

Dawei Wang, Zhongyang Yu, Yuxia Qi, Kaiwen Hu, Tian Zhou, Jing Liu, and Wei Rao

Therapeutic cancer vaccines have been vigorously sought to bolster host adaptive immunity against metastatic cancers, but tumor heterogeneity, ineffective antigen utilization, and immunosuppressive tumor microenvironment hinder their clinical applications. Autologous antigen adsorbability and stimulus-release carrier coupling with immunoadjuvant capacity are urgent for personalized cancer vaccines. Here, we propose a perspective strategy of using a multipotent gallium-based liquid metal (LM) nanoplatform for personalized in situ cancer vaccines (ISCVs). The antigen-capturing and immunostimulatory LM nanoplatform can not only effectively destroy orthotopic tumors to generate multifarious autologous antigens upon external energy stimulation (photothermal/photodynamic effect) but also capture and transport antigens into dendritic cells (DCs) to enhance antigen utilization (adequate DCs uptake, antigen-endo/lysosomal escape) and facilitate DCs activation (mimic alum immunoadjuvant capacity), which ultimately awaken systemic antitumor immunity (expand cytotoxic T lymphocytes and modulate tumor microenvironment). With immune checkpoint blockade (anti-PD-L1) to further relieve the immunosuppressive tumor microenvironment, the positive tumoricidal immunity feedback loop was established to effectively eliminate orthotopic tumors, inhibit abscopal tumor growth, relapse, and metastasis as well as tumor-specific prevention. Collectively, this study demonstrates the potential of a multipotent LM nanoplatform for personalized ISCVs, which will open frontier exploration of LM-based immunostimulatory biomaterials and may encourage further investigation of precise individualized immunotherapy.

https://pubs.acs.org/doi/10.1021/acsnano.3c00941

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