▲ Vol 35 Issue 22 |  June 01, 2023

Cuproptosis Induced by ROS Responsive Nanoparticles with Elesclomol and Copper Combined with αPD-L1 for Enhanced Cancer Immunotherapy

Boda Guo, Feiya Yang, Lingpu Zhang, Qinxin Zhao, Wenkuan Wang, Lu Yin, Dong Chen, Mingshuai Wang, Sujun Han, Haihua Xiao, Nianzeng Xing

Immunotherapy
In article 2212267, Haihua Xiao, Nianzeng Xing, and co-workers present a novel therapeutic strategy to achieve synergistic cancer immunotherapy via cuproptosis induced by reactive oxygen species (ROS)-responsive nanomedicine loaded with elesclomol and copper (NP@ESCu). With this approach, the tumor microenvironment is reprogrammed, and the expression of PD-L1 is increased, which consequently improves responsiveness of immunotherapy.

https://onlinelibrary.wiley.com/doi/10.1002/adma.202370152

▲ Vol 35 Issue 22 |  June 01, 2023

Hygrothermic Wood Actuated Robotic Hand

Lulu Bai, Yaoxin Zhang, Shuai Guo, Hao Qu, Zhen Yu, Haipeng Yu, Wenshuai Chen, Swee Ching Tan

Wood Actuators
In article number 2211437, Wenshuai Chen, Swee Ching Tan, and co-workers report a wooden robotic hand for dexterous object–hand interactions and fire rescue that generates stretching and bending responses to moisture and heat/light stimulation. Multiple advantages are realized by one device, including good mechanical properties, multi-stimulus response, complex deformation, wide working temperature range, low manufacturing cost, and biocompatibility.

https://onlinelibrary.wiley.com/doi/10.1002/adma.202370158

▲ Vol 130 Issue 22 |  June 02, 2023

Dynamics of Associative Polymers with High Density of Reversible Bonds

Shifeng Nian, Shalin Patil, Siteng Zhang, Myoeum Kim, Quan Chen, Mikhail Zhernenkov, Ting Ge, Shiwang Cheng, and Li-Heng Cai (蔡历恒)

An associative polymer carries many stickers that can form reversible associations. For more than 30 years, the understanding has been that reversible associations change the shape of linear viscoelastic spectra by adding a rubbery plateau in the intermediate frequency range, at which associations have not yet relaxed and thus effectively act as crosslinks. Here, we design and synthesize new classes of unentangled associative polymers carrying unprecedentedly high fractions of stickers, up to eight per Kuhn segment, that can form strong pairwise hydrogen bonding of ～20kBT without microphase separation. We experimentally show that reversible bonds significantly slow down the polymer dynamics but nearly do not change the shape of linear viscoelastic spectra. This behavior can be explained by a renormalized Rouse model that highlights an unexpected influence of reversible bonds on the structural relaxation of associative polymers.

https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.130.228101

▲  June 03, 2023

New Crops创刊号

New Crops is dedicated to serving crop researchers and breeders by publishing novel findings that have gone through rigorous peer-review and have significant impact to the field. The journal covers a very wide range of area, including biology, agronomy, chemistry, mathematics, computer science and physics.

New Crops publishes Original Research Paper, Review Article, Short Communication, Technical Note, Correspondence, Short Review, Conference Report, Opinion Paper and Feature Article.

https://www.keaipublishing.com/en/journals/new-crops/

▲ Vol 145 Issue 22 |  June 07, 2023

Oral Hydrogel Microbeads-Mediated In Situ Synthesis of Selenoproteins for Regulating Intestinal Immunity and Microbiota

Jiang Ouyang, Bo Deng, Binhua Zou, Yongjiang Li, Qingyue Bu, Yuan Tian, Mingkai Chen, Wei Chen, Na Kong, Tianfeng Chen, and Wei Tao

Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as a protein drug that is easily denatured or degraded in the acidic environment of the stomach, efficient oral delivery of selenoprotein is a great challenge. Herein, we innovated an oral hydrogel microbeads-based biochemical strategy that can in situ synthesize selenoproteins, therefore bypassing the necessity and harsh conditions for oral protein delivery while effectively generating selenoproteins for therapeutic applications. The hydrogel microbeads were synthesized by coating hyaluronic acid-modified selenium nanoparticles with a protective shell of calcium alginate (SA) hydrogel. We tested this strategy in mice with inflammatory bowel disease (IBD), one of the most representative diseases related to intestinal immunity and microbiota. Our results revealed that hydrogel microbeads-mediated in situ synthesis of selenoproteins could prominently reduce proinflammatory cytokines secretion and mediate immune cells (e.g., reduce neutrophils and monocytes and increase immune regulatory T cells) to effectively relieve colitis-associated symptoms. This strategy was also able to regulate gut microbiota composition (increase probiotics abundance and suppress detrimental communities) to maintain intestinal homeostasis. Considering intestinal immunity and microbiota widely associated with cancers, infections, inflammations, etc., this in situ selenoprotein synthesis strategy might also be possibly applied to broadly tackle various diseases.

https://pubs.acs.org/doi/10.1021/jacs.3c02179

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静远嘲风（MY Scimage） 成立于2007年，嘲风取自中国传统文化中龙生九子，子子不同的传说，嘲风为守护屋脊之瑞兽，喜登高望远；静远取自成语“宁静致远”，登高莫忘初心，远观而不可务远。

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