▲ Vol 16 Issue 8 | August 23, 2022

Discovering the Secret of Diseases by Incorporated Tear Exosomes Analysis via Rapid-Isolation System: iTEARS

Liang Hu, Ting Zhang, Huixiang Ma, Youjin Pan, Siyao Wang, Xiaoling Liu, Xiaodan Dai, Yuyang Zheng, Luke P. Lee, and Fei Liu

Nanoscale small extracellular vesicles (sEVs, exosomes) in tears allow us to investigate the multisignatures of diseases. However, the translations of tear sEVs for biomarker discovery and clinical diagnostics are practically limited by low recovery, long processing time, and small sample volume. Here, we report an incorporated tear-exosomes analysis via rapid-isolation system (iTEARS) via nanotechnology to discover the secrets of ocular disorders and systemic diseases. We isolate exosomes rapidly with high yield and purity from a few teardrops (～10 μL) within 5 min via nanoporous membrane-based resonators for the quantitative detection and biomarker discovery through proteomic and transcriptomic analysis. We have identified 904 proteins, among which 228 proteins are discovered, 426 proteins are detected from exosomes of dry eye disease, and demonstrate CALML5, KRT6A, and S100P for the classification of dry eye disease. We have also investigated 484 miRNAs in tear exosomes and show miR-145-5p, miR-214-3p, miR-218-5p, and miR-9-5p are dysregulated during diabetic retinopathy development. We believe iTEARS can be used for improving molecular diagnostics via tears to identify ocular disorders, systemic diseases, and numerous other neurodegenerative diseases and cancer.

https://pubs.acs.org/doi/10.1021/acsnano.2c02531

▲ Vol 126 Issue 33 | August 25, 2022

Revealing Temperature-Dependent Noise Sources in Aluminum Oxide Josephson Junctions Using Topological Analysis

Chuanbing Han, Huihui Sun, Chaofeng Hou, Shuya Wang, Jinlong Xu, and Zheng Shan

Despite many improvements in the quality and reliability of Josephson junctions, the understanding of their noise sources, particularly the effect of oxidation parameters on the atomic arrangement of the interface and barrier layers, remains elusive. Here, we apply a Voronoi tessellation, a geometrically structural and topological analysis, to the amorphous barriers in aluminum oxide junctions. To enable this analysis, we perform million-atom molecular dynamics simulations to develop oxidation models at different temperatures. We find that the temperature introduces noise by changing the atomic compactness of oxides in the junctions. High-temperature oxidation aggravates the structural disorder and surface roughness of the barrier. This work will pave the way for illustrating the microscopic noise origin of amorphous oxides, which can transform our fundamental understanding of noncrystalline materials and qubit decoherence mechanisms.

https://pubs.acs.org/doi/10.1021/acs.jpcc.2c04056

▲ Vol 09 Issue 24 | August 25, 2022

Quantifying Wetting Dynamics with Triboelectrification

Xiaolong Zhang, Michele Scaraggi, Youbin Zheng, Xiaojuan Li, Yang Wu, Daoai Wang, Daniele Dini, Feng Zhou

Quantifying Wetting Dynamics
There exists an intrinsic link between wetting and charge generation due to fluid motion over surfaces made using triboelectric layers. In article number 2200822, Michele Scaraggi, Daoai Wang, Daniele Dini, Feng Zhou, and co-workers show that wetting dynamics can be accurately quantified and tracked using solid-liquid triboelectrification. Theoretical underpinning reveals how surface micro-/nano-geometries regulate stability/infiltration, also demonstrating the generality of the theoretical approach in understanding wetting transitions in real environments.

https://onlinelibrary.wiley.com/doi/10.1002/advs.202270154

▲ Vol 02 Issue 04 | August 31, 2022

MXene based nanocomposite films

Lei Li, Qunfeng Cheng

Henan University was established as “the Preparatory School for Further Study in Europe and America” in 1912. Almost 100 years later, a new two-dimensional (2D) material, MXene, was first reported in 2011. The cover represents the promising and quickly development of new 2D MXene material for applications in electromagnetic interference shielding, thermal conductivity, supercapacitors, etc.

https://onlinelibrary.wiley.com/doi/10.1002/EXP.20210347

▲ Vol 02 Issue 04 | August 31, 2022

Brain co-delivery of first-line chemotherapy drug and epigenetic bromodomain inhibitor for multidimensional enhanced synergistic glioblastoma therapy

Yanjie Liu, Wendie Wang, Dongya Zhang, Yajing Sun, Fangzhou Li, Meng Zheng, David B. Lovejoy, Yan Zou, Bingyang Shi

Yan Zou and co-workers present a temozolomide and epigenetic bromodomain inhibitor co-encapsulated biomimetic nanomedicine platform that achieves prolonged blood circulation time, excellent blood brain barrier (BBB) permeability, and multidimensional enhanced glioblastoma (GBM) synergistic chemoimmunotherapy in both primary and recurrent orthotopic mice models with significant extended survival rate and little side effects.

https://onlinelibrary.wiley.com/doi/10.1002/EXP.20210348

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静远嘲风（MY Scimage） 成立于2007年，嘲风取自中国传统文化中龙生九子，子子不同的传说，嘲风为守护屋脊之瑞兽，喜登高望远；静远取自成语“宁静致远”，登高莫忘初心，远观而不可务远。