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给自己做个研究生招生广告（常年有效）
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1) 耐药性细菌感染被列为国家十大重大疾病，也是世界范围内的临床治疗难题。大环内酯类抗生素（红霉素、克拉霉素、阿奇霉素等）通过与细菌核糖体的23S RNA结合，阻断细菌蛋白质的合成释放通道达到抑菌作用。但细菌通过甲基化转移酶修饰抗菌靶点、外排泵蛋白泵出药物等方式获得耐药性。我们课题组通过GOLD和Amber等软件建模发现了药物与细菌rRNA 的新作用靶点和新作用模式（与Purdue大学合作），并利用有机化学的新方法新技术修饰大环内酯分子，以增强与rRNA的结合力；通过体外、体内抗菌实验证明候选化合物的抗敏感菌和抗耐药菌活性（与北京大学医学部、协和医学院等合作）。我们目前的研究兴趣包括我们自己课题组命名的烃基内酯（alkylide）系列、以及热门的酮内酯（ketolide）和酰内酯（acylide）系列，当前设计的重点是多靶点抗菌分子。
2）治疗老年痴呆病目前的靶点多有不足，我们课题组全合成天然产物来源的类似物，通过全新作用机制提供一条治疗老年痴呆病的新途径。
1. Liang Jian-Hua*, Han Xu. Strucutre-activity relationships and mechanism of action of macrolides derived from erythromycin as antibacterial agents. Current Topics in Medicinal Chemistry,2013, 13(24):3131-3164 (IF: 3.453) (Invited Review)
2. Liang Jian-Hua*, Lv Wei, Li Xiao-Li, An Kun, Cushman Mark, Wang He, Xu Ying-Chun. Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. Bioorganic & Medicinal Chemistry Letters. 2013, 23(5): 1387-1393.(IF: 2.331)
3. Liang Jian-Hua*, An Kun, Lv Wei, Cushman Mark*, Wang He, Xu Ying-Chun.Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides. European Journal of Medicinal Chemistry. 2013, 59, 54-63. (IF: 3.432)
4. Liang Jian-Hua*, Li Xiao-Li, Wang He, An Kun, Wang Yue-Ying, Xu Yin-Chun, Yao Guo-Wei. Structure-activity relationships of novel alkylides: 3-O-arylalkyl clarithromycin derivatives with improved antibacterial activities. European Journal of Medicinal Chemistry, 2012,49, 289-303. (IF: 3.432)
5. Cinelli Maris A., Reddy P. V. Narashimha, Lv Peng-Cheng, Liang Jian-Hua, Chen Lian, Agama, Pommier Yves, Breemen Richard B. van, Cushman Mark*. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs Indotecan (LMP400) and Indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons.Journal of Medicinal Chemistry, 2012, 55, 10844-10862. (IF: 5.480)
6. Liang Jian-Hua*, Dong Li-Jin, Wang Yue-Ying, Yao Guo-Wei, An Mao-Mao, Wang Rui. Synthesis and antibacterial activity of 2, 3-dehydro-3-O-(3-aryl-E-prop-2-enyl)-10, 11-anhydroclarithromycin derivatives. Journal of Antibiotics, 2011,64(4): 333-337. (IF: 2.041)
7. Liang Jian-Hua*, Dong Li-Jin, Wang He, An Kun, Li Xiao-Li, Yang Li, Yao Guo-Wei, Xu Yin-Chun. Synthesis and antibacterial activities of 6-O-methylerythromycin A 9-O-(3-aryl-2-propenyl) oxime ketolide, 2,3-enol ether, and alkylide analogues. European Journal of Medicinal Chemistry, 2010,45 (9): 3627-3635. (IF: 3.432)
8. Liang Jian-Hua*, Wang Yue-Ying, Wang He, Li Xiao-Li, An Kun, Xu Ying-Chun, Yao Guo-wei. Synthesis and antibacterial activities of a novel alkylide: 3-O-(3-aryl-2-propargyl) and 3-O-(3-aryl-2-propenyl)clarithromycin derivatives. Bioorganic & Medicinal Chemistry Letters. 2010 , 20 (9): 2880-2883 (IF: 2.331)
9. Liang Jian-Hua*, Wang Yue-Ying, Zhu Dan-Yang, Dong Li-Jing, An Mao-Mao, Wang Rui, Yao Guo-Wei. Design, synthesis and antibacterial activity of a novel alkylide: 3-O-(3-aryl-propenyl)clarithromycin derivatives. Journal of Antibiotics, 2009,62 (11): 605-611. (IF: 2.041)
热切期待有理想/愿意奋斗的学生加入！
2014年9月21日更新
https://blog.sciencenet.cn/blog-51231-429034.html
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