题目：Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

越来越复杂了，启动子甲基化，现在有来了羟甲基化，还是动态变化的过程，越来越搞不懂了，生命啊，我将如何研究你，你就想千变万化的一首诗，喜欢读你，但是有时候读不懂，因为你是穿越历史而来的。

作者：Gabriella Ficz1 发了好几篇文章看来是研究表观遗传学的老手

期刊：nature

摘要：作者介绍了甲基化和羟甲基化的比价，发现羟甲基化在常染色体分布，发现与ES细胞的分化有关，羟甲基化减少伴随着去能行的丧失和分化的开始。指出有了两个技术一个事抗体技术，一个是测序技术。

1 。。。。。is important roles in the genome function and.什么是很重的

2 generate by which seem

3 we proposed that the balance between

文章很短，有四个数据

1 Figure 1 | Distribution of 5-hydroxymethylcytosine in the mouse genome

2Figure 2 | Genetic relationship between methylation and hydroxymethylation.

3 Figure 3 | Strand specificity and sequence context of methylation and hydroxymethylation

4 Figure 4 | Gene expression and promoter methylation in ES cells and during differentiation.