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已有 4172 次阅读 2011-11-21 11:45 |个人分类:SCI论文|系统分类:论文交流| 论文, 最新

mol med 杂志(IF:5.908)最近已同意发表我们小组论文,有兴趣者可到PubMed查看英文全文。
 
ApoA-IABCA1结合激活信号通路并介导细胞内胆固醇流出
摘要:胆固醇逆向转运 (RCT) 是抗动脉粥样硬化的关键步骤,ATP结合盒转运体A1 (ABCA1) 介导的细胞磷脂和胆固醇流向载脂蛋白-AI (apoA-I) RCT的起始步骤, apoA-IABCA1结合导致apoA-I酯化形成高密度脂蛋白 HDL)。研究表明,apoA-IABCA1结合激活信号转导通路并调节ABCA1的活性以及脂质转运。这个过程中的关键调节分子有蛋白激酶A (PKA)、蛋白激酶C (PKC)JAK2Cdc42Ca2+,并且许多因素能影响二者的结合。本文关注ABCA1apoA-I结合的机制,以及结合时所激活的信号通路.
The Interaction of ApoA-I and ABCA1 Triggers Signal Transduction Pathways to Mediate Efflux of Cellular Lipids.
Source

Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang, 421001, China.

Abstract

Reverse cholesterol transport (RCT) has been characterized as a crucial step for anti-atherosclerosis, which is initiated by ATP-binding cassette A1 (ABCA1) to mediate the efflux of cellular phospholipids and cholesterol to lipid-free apolipoprotein A-I (apoA-I), however, the mechanisms underlying apoA-I/ABCA1 interaction to lead to the lipidation of apoA-I are poorly understood. There are several models proposed for the interaction of apoA-I with ABCA1 as well as lipidation of apoA-I mediated by ABCA1. ApoA-I markedly increases the levels of ABCA1 protein, ABCA1 inturn can stabilize apoA-I. The interaction of apoA-I with ABCA1 could activate signaling molecules that modulate post-translational ABCA1 activity or lipid transport activity. The key signaling molecules in these process include protein kinase A (PKA), protein kinase C (PKC), Janus kinase 2 (JAK2), Rho GTPases and Ca(2+), and many factors could also influence the interaction of apoA-I with ABCA1. This review will summarize these mechanisms for the apoA-I interaction with ABCA1 as well as the signal transduction pathways involved in these process.



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