2024年7月14日，Elsevier 旗下top期刊《Talanta》在线发表了云南师范大学化学化工学院龚行教授课题组最新研究成果《Construction of a monoclonal molecular imprinted sensor with high affinity for specific recognition of influenza A virus subtype》。云南师范大学化学化工学院龚行教授为第一兼通讯作者。合作者为湖南湘潭大学化学化工学院蔡昌群教授。

https://www.sciencedirect.com/science/article/pii/S0039914024009470#undfig1

ABSTRACT

Although molecular imprinting technology has been widely used in the construction of virus sensors, it is still a great challenge to identify subtypes viruses specifically because of their high similarity in morphology, size and structure. Here, a monoclonal molecular imprinted polymers (MIPs) sensor for recognition of H5N1 is constructed to permit the accurate distinguishing of H5N1 from other influenza A virus (IAV) subtypes. Firstly, H5N1 are immobilized on magnetic microspheres to produce H5N1-MagNPs, then the high affinity nanogel H5N1-MIPs is prepared by solid phase imprinting technique. When H5N1-MIPs is combined with MagNP-H5N1, different concentrations of H5N1 are added for competitive substitution. The quantitative detection of H5N1 is realized by the change of fluorescence intensity of supernatant. As expected, the constructed sensor shows satisfactory selectivity, and can identify the target virus from highly similar IAV subtypes, such as H1N1, H7N9 and H9N2. The sensor was highly sensitive, with a detection limit of 0.58 fM, and a selectivity factor that is comparable to that of other small MIPs sensors is achieved. In addition, the proposed sensor is cheap, with a cost of only RMB 0.08 yuan. The proposed monoclonal sensor provides a new method for the specific recognition of designated virus subtype, which is expected to be used for large-scale screening and accurate treatment of infected people.

扩张阅读：

云师大化学化工学院龚行教授在《Analytica Chimica Acta》上发表最新研究成果

云师大化学化工学院龚行教授在《Chemical Engineering Journal》上发表最新研究成果

云师大化学化工学院龚行教授在《Chemical Engineering Journal》上发表最新研究成果

龚行-云南师范大学化学化工学院

龚行

有机化学专业，教授，博士生（硕士生）导师，博士后

联系方式：hgong@xtu.edu.cn；睿智楼2号楼517室

课题组主页：https://www.x-mol.com/groups/hang_gong

学术任职及兼职

1.  国家科技计划项目评审专家库专家

2.  教育部学位论文评审专家

3. 中国感光学会青年理事

4.  佛山湘潭大学绿色智造研究院特聘专家

5.  Angew. Chem. Int. Ed., Nat. Commun., Anal. Chem., Org. Lett.等权威期刊审稿人

主要研究方向

方向：生物传感；新型纳米材料合成与应用

简介：主持国家级、省部级等项目10余项；荣获省自科三等奖等奖项多项；以第一作者或通讯联系人在Angew. Chem. Int. Ed., Anal. Chem., ACS Sens., Biosens. Bioelectron., Org. Lett.等著名期刊上发表SCI论文50余篇，获授权中国发明专利8项。

人才培养：培养研究生获得 “研究生国家奖学金” 2人次 (2万元/人)；培养研究生获得 “新宙邦奖学金” 1人次 (0.5万元/人)；培养研究生获得 “湖南省2018届优秀毕业生”、“湘潭大学研究生校长奖”、“湘潭大学优秀毕业生”各1次，“湘潭大学三好研究生”2次；指导本科生参加“湖南省大学生课外化学化工类创新作品竞赛”，获二等奖2次，三等奖3次。

主要招生专业

有机化学；分析化学；生物传感

教育与工作经历:

2013年09月-2015年03月，加拿大 McGill University化学系，博士后，合作导师：Chao-Jun Li

2005年12月～2006年06月，香港理工大学，访问学者

2023年07月至今，云南师范大学化学化工学院药物化学系，教授

2021年01月～2023年07月，湘潭大学化学学院有机教研室，教授

2012年01月～2020年12月，湘潭大学化学学院有机教研室，副教授

2007年11月～2011年12月，湘潭大学化学学院有机教研室，讲师

2005年07月～2007年10月，湘潭大学化学学院有机教研室，助教

2011年06月，湘潭大学化学学院有机化学专业，获理学博士学位

2005年06月，湘潭大学有机化学专业，获理学硕士学位

2002年06月，湘潭大学化学专业，获理学学士学位

获奖成果和荣誉称号：

1. 龚行，云南师范大学化学化工学院高层次人才 (第五层次)，2023年

2. 龚行，加拿大魁北克省政府优秀博士后奖 (每年全国限评10人)，2013年

3. 龚行，廖云峰，王建方，王丹桂，李士光，张景雨，湖南省自然科学三等奖，2020年

4. 龚行，6^th Edition of International Popular Scientist Awards, Best Research Award，2023年

5. 龚行，曾会应，周峰，湖南省化学化工学会第十四届优秀论文一等奖，2016年

6. 龚行，湘潭市自然科学优秀学术论文“成果奖”，2015年

7. 龚行，湘潭大学韶峰人才“学术骨干”，2022年

8. 龚行，湘潭市高层次人才D类(高级)人才，2019年

主持科研项目

1. 云南师范大学高层次人才引进项目，病毒光化学传感器的构建与机理研究，执行时间：2023/07-2027/07

2. 国家自然科学基金青年项目，水相中铑催化的双 C-H 键活化直接脱氢偶联形成 C(芳基)-C(芳基)键的反应研究，执行时间：2015/01-2017/12

3. 湖南省自科面上项目，基于可再生的氨基酸电化学脱羧反应构建碳碳键及碳杂键的研究，执行时间：2022/01-2024/12

4. 湖南省教育厅重点项目，基于甲酰胺衍生物为合成子的一步构建六元含氮杂芳环反应研究，执行时间：2018/09-2021/12

5. 湖南省自科面上项目，氧化石墨烯催化的(杂)芳烃直接官能团化反应研究，执行时间：2018/01-2020/12

6. 湖南省教育厅优秀青年项目，羧基导向的过渡金属催化的C-H键直接活化反应构筑联芳烃骨架的研究，执行时间：2015/09-2018/12

7. 湖南省教育厅项目，Baylis-Hillman加成产物应用于手性螺旋聚合反应的研究，执行时间：2008/01-2010/12

8. 教育部重点实验室开放课题，Baylis-Hillman反应的研究，执行时间：2009/01-2011/12

9. 广东赛普电器制造有限公司，洗碗机软水器性能及树脂性能研究及分析检测技术执行时间：2020-2021

10. 江西天宇化工有限公司，新型nicofluprole 类似物的设计、合成及生物活性研究，执行时间：2021/11-2027/07

11. 一帆生物科技集团有限公司，一种生物代谢物的合成，执行时间：2021.05-2021.07

代表性著作、论文、专利等

代表性论文 (第一或通讯作者)：

57. Hang Gong, Huiying Zeng, Feng Zhou, Chaojun Li*, Rhodium(I)-Catalyzed Regiospecific Dimerization of Aromatic Acids: Two Direct C-H Bond Activations in Water, Angew. Chem. Int. Edit. 2015, 54, 5718 (中国科学院一区，IF₂₀₁₅ = 11.709)

56. Hang Gong*, Li Tang, Feng Chen, Chunyan Chen, Yi Cheng, Changqun Cai*, Self-service multimodal detection of subtype influenza A virus H5N1 by visual portable molecular imprinting sensor, Chem. Eng. J. 2024, 483, 148946. (中国科学院一区，IF₂₀₂₃ = 15.1)

55. Hang Gong*, Shufen Yao, Xiaojia Zhao, Feng Chen, Chunyan Chen, Changqun Cai*, Construction of an autofluorescence interference-free phosphorescence biosensor for the specific detection of TK1 mRNA, Anal. Chim. Acta 2024, DOI: 10.1016/j.aca.2024.342508.   (中国科学院一区，IF₂₀₂₃ = 6.2)

54. Hang Gong*, Siyu Chen, Li Tang, Feng Chen, Chunyan Chen, Changqun Cai*, Ultra-Sensitive Portable Visual Paper-Based Viral Molecularly Imprinted Sensor without Autofluorescence Interference, Anal. Chem. 2023, 95, 17691. (中国科学院一区，IF₂₀₂₃ = 7.4)

53. Hang Gong*, Li Tang, Chunyan Chen, Feng Chen, Changqun Cai*, Portable Paper-Based Molecularly Imprinted Sensor for Visual Real-Time Detection of Influenza Virus H5N1, Chem. Eng. J. 2023, 477, 146990.  (中国科学院一区，IF₂₀₂₃ = 15.1)

52. Li Tang, Kunsong Liang, Lingyun Wang, Chunyan Chen, Changqun Cai*, Hang Gong*, Construction of an Ultrasensitive Molecularly Imprinted Virus Sensor Based on an “Explosive” Secondary Amplification Strategy for the Visual Detection of Viruses, Anal. Chem. 2022, 94, 13879.  (中国科学院一区，IF₂₀₂₂ = 8.008)

51. Ganping Cai, Junyu Yang, Lingyun Wang, Chunyan Chen, Changqun Cai*, Hang Gong*, A point -to-point “cap” strategy to construct a highly selective dual-function molecularly-imprinted sensor for the simultaneous detection of HAV and HBV, Biosens. Bioelectron. 2022, 219, 114794. (中国科学院一区，IF₂₀₂₂ = 12.545)

50. Siyu Chen, Ganping Cai, Xiaoyu Gong, Lingyun Wang, Changqun Cai*, Hang Gong*, Non-autofluorescence Detection of H5N1 Virus Using Photochemical Aptamer Sensors Based on Persistent Luminescent Nanoparticles, ACS Appl. Mater. Interfaces 2022, 14, 46964. (中国科学院一区，IF₂₀₂₂ = 10.383)

49. Lingyun Wang, Kunsong Liang, Li Tang, Hang Gong*, Chunyan Chen, Changqun Cai*, Photonic and Magnetic Dual-Responsive Molecularly Imprinted Sensor for Highly Specific Recognition of Enterovirus 71, ACS Sens. 2021, 6, 3715. (中国科学院一区，IF₂₀₂₂ = 9.618)

48. Yanjie Wang, Yuhan Zhao, Changqun Cai, Lingyun Wang*, Hang Gong*, Dioxygen-Triggered Oxosulfonylation/Sulfonylation of Terminal Olefins toward β‑Keto Sulfones/Sulfones, Org. Lett. 2021, 23, 8296. (中国科学院一区，IF₂₀₂₁ = 6.005)

47. Guilin Xie, Yuhan Zhao, Changqun Cai, Guo-Jun Deng, Hang Gong*, Palladium-Catalyzed Direct and Specific C-7 Acylation of Indolines with 1,2-Diketones, Org. Lett. 2021, 23, 410. (中国科学院一区，IF₂₀₂₁ = 6.005)

46. Yi Liu, Tian Shen, Jing Li, Hang Gong*, Chunyan Chen, Xiaoming Chen, Changqun Cai*, Ratiometric fluorescence sensor for the microRNA determination by catalyzed hairpin assembly, ACS Sens. 2017, 2, 1430. (中国科学院一区，IF₂₀₂₂ = 9.618)

45. Yunpeng Han, Feng Zhang, Hang Gong*, Changqun Cai*, Functional three helix molecular beacon fluorescent “turn-on” probe for simple and sensitive simultaneous detection of two HIV DNAs, Sensor. Actuat B-Chem. 2019, 281, 303. (中国科学院一区，IF₂₀₂₂ = 9.221)

44. Yi Liu, Huan Wang, Shiyu Li, Hang Gong*, Chunyan Chen, Xiaoming Chen, Changqun Cai*, Ultrasensitive detection of thrombin based on MoS₂-aptamer biosensors by resonance light scattering technique, Sensor. Actuat B-Chem. 2018, 258, 402. (中国科学院一区，IF₂₀₂₂ = 9.221)

43. Yi Liu, Tian Shen, Ling Hu, Hang Gong*, Chunyan Chen, Xiaoming Chen, Changqun Cai*, Development of a thermosensitive molecularly imprinted polymer resonance light scattering sensor for rapid and highly selective detection of Hepatitis A virus in vitro, Sensor. Actuat B-Chem. 2017, 253, 1188. (中国科学院一区，IF₂₀₂₂ = 9.221)

42. Feng Chen, Yi Liu, Chunyan Chen, Hang Gong*, Changqun Cai*, Xiaoming Chen, Respective and simultaneous detection tumor markers CA125 and STIP1 using aptamer-based fluorescent and RLS sensors, Sensor. Actuat B-Chem. 2017, 245, 470. (中国科学院一区，IF₂₀₂₂ = 9.221)

41. Yunpeng Han, Feng Zhang, Hang Gong*, Changqun Cai*, Multifunctional G-quadruplex-based fluorescence probe coupled with DNA-templated AgNCs for simultaneous detection of multiple DNAs and MicroRNAs, Anal. Chim. Acta. 2019, 1053, 105. (中国科学院一区，IF₂₀₂₂ = 6.911)

40. Feng Chen, Yi Liu, Rong Liao, Hang Gong*, Chunyan Chen, Xiaoming Chen, Changqun Cai*, Reduced graphene oxide as a resonance light-scattering probe for thrombin detection using dual-aptamer-based dsDNA, Anal. Chim. Acta. 2017, 985, 141. (中国科学院一区，IF₂₀₂₂ = 6.911)

39. Jiawen Yin, Jingyu Zhang, Changqun Cai, Guo-Jun Deng, Hang Gong*, Catalyst-Free Transamidation of Aromatic Amines with Formamide Derivatives and Tertiary Amides with Aliphatic Amines, Org. Lett. 2018, 21, 387. (中国科学院一区，IF₂₀₁₈ = 6.555)

38. Lesong Li, Feng Zhang, Guo-Jun Deng, Hang Gong*, Palladium-Catalyzed Direct α-Ketoesterification of 8-Methylquinoline Derivatives with α-Ketoacids via Dehydrogenation Coupling Reaction, Org. Lett. 2018, 20, 7321. (中国科学院一区，IF₂₀₁₈ = 6.555)

37. Jingxian Fang, Lesong Li, Chu Yang, Jinping Chen, Guo-Jun Deng, Hang Gong*, Tandem Oxidative Ring-Opening/Cyclization Reaction in Seconds in Open Atmosphere for the Synthesis of 1-Tetralones in Water–Acetonitrile, Org. Lett. 2018, 20, 7308. (中国科学院一区，IF₂₀₁₈ = 6.072)

36. Dangui Wang, Jingxian Fang, Guo-Jun Deng, Hang Gong*, Catalyst-free Decarboxylative Trifluoromethylation/ Perfluoroalkylation of Benzoic Acid Derivatives in Water–Acetonitrile, ACS Sustain. Chem. Eng. 2017, 5, 6398. (中国科学院一区，IF₂₀₂₂ = 9.224)

35. Dangui Wang, Guo-Jun Deng, Shiya Chen, Hang Gong*, Catalyst-free Direct C-H Trifluoromethylation of Arene in Water–Acetonitrile, Green Chem. 2016,18, 5967 (中国科学院一区，IF₂₀₂₂ = 11.034)

34. Chuanming Yin, Cheng-an Tao, Fenglian Cai, Chenchao Song, Hang Gong*, Jianfang Wang*, Effects of activation temperature on the deoxygenation, specific surface area and supercapacitor performance of graphene, Carbon 2016, 109, 558 (中国科学院一区，IF₂₀₂₂ = 11.307)

33. Shiguang Li, Guo-Jun Deng, Feifei Yin, Chao-Jun Li*, Hang Gong*, Rhodium-catalyzed Regiospecific C–H ortho-Phenylation of Benzoic Acids with Cu/Air as Oxidant, Org. Chem. Front. 2017, 4, 417 (中国科学院一区，IF₂₀₂₂ = 5.456)

32. Jingyu Zhang, Shiya Chen, Fangfang Chen, Wensheng Xu, Guojun Deng, Hang Gong*, Dehydrogenation of N-Heterocycles Using Graphene Oxide as a Versatile Metal-free Catalyst under Air, Adv. Synth. Catal. 2017, 359, 2358 (中国科学院一区，IF = 5.981)

31. Yunpeng Han, Feng Zhang, Hang Gong*, Changqun Cai*, Double G-quadruplexes in a copper nanoparticle based fluorescent probe for determination of HIV genes, Microchim. Acta. 2019, 186, 30. (IF₂₀₂₂ = 6.408)

30. Yanjie Wang, Xia Meng, Changqun Cai, Lingyun Wang*, Hang Gong*, Radical Cross-Coupling Reaction Based on Hydrogen Atom Abstraction of DMF and Decarboxylation of α-Ketoacid under Electricity, J. Org. Chem. 2022, 87, 15042. (IF₂₀₂₂ = 4.198)

29. Wenbao Feng, Caishuang Liang, Hang Gong*, Changqun Cai*, Sensitive detection of Japanese encephalitis virus by surface molecularly imprinted technique based on fluorescent method, New. J. Chem. 2018, 42, 3503.  (IF₂₀₂₂ = 3.925)

28. Hang Gong*, Fangyuan Zhou, Changqun Cai, Construction of benzoheterocycles by the reaction of α-arylglyoxylic acids and orthofunctionalized aniline under mild and minimal conditions, Org. Biomol. Chem. 2023, 21, 7639. (IF₂₀₂₃ = 3.2)

27. Hang Gong*, Yuhan Zhao, Xia Meng, Changqun Cai, Dioxygen-Triggered β-Hydroxysulfonylation of Terminal Olefins Controlled by DABCO, Eur. J. Org. Chem. 2023, e202300675 (IF₂₀₂₃ = 2.8)

26. Yuhan Zhao, Xia Meng, Changqun Cai, Lingyun Wang, Hang Gong*, Synthesis of α-Ketoamides via Electrochemical Decarboxylative Acylation of Isocyanides Using α-Ketoacids as an Acyl Source, Asian J. Org. Chem. 2022, 11, e202100748. (IF₂₀₂₂ = 2.7)

25. Siyu Chen, Lianghui Luo, Lingyun Wang,* Chunyan Chen, Hang Gong*, Changqun Cai*, A sandwich sensor based on imprinted polymers and aptamers for highly specific double recognition of viruses, Analyst 2021, 146, 3924. (IF₂₀₂₂ = 5.227)

24. Min Wang, Xia Meng, Changqun Cai, Lingyun Wang*, Hang Gong*, Synthesis of benzisothiazoles by a three-component reaction using elemental sulfur and ammonium as heteroatom components under transition metal-free conditions, Green Synth. Catal. 2022, 3, 168. (New Journal)

23. Jiawen Yin, Xia Meng, Changqun Cai, Lingyun Wang*, Hang Gong*, Sulfur-promoted, one-pot, and metal-free conversion of aromatic aldehydes to nitriles using an inorganic ammonium salt as the nitrogen source, Green Synth. Catal. 2023, 4, 46. (New Journal)

22. Fangyuan Zhou, Lesong Li, Kao Lin, Feng Zhang, Guo-Jun Deng, Hang Gong*, Iron-Catalyzed Cleavage Reaction of Keto Acids with Aliphatic Aldehydes for the Synthesis of Ketones and Ketone Esters, Chem. Eur. J. 2020, 26, 4246 (IF₂₀₂₂ = 5.020)

21. Xiaoming Zhao, Zhouhao Wu, Zenghui Zhang, Ning Wang, Cheng-An Tao, JianfangWang∗, Hang Gong*, The polymer composite electrolyte with polyethylene oxide-grafted graphene oxide as fillers toward stable highcurrent density lithium metal anodes, Mater. Res. Express 2021, 8, 105305. (IF₂₀₂₂ = 2.025)

20. Xiaoming Zhao, Cheng-an Tao, Yujiao Li, Xianzhe Chen, Jianfang Wang, Hang Gong*, Preparation of gel polymer electrolyte with high lithium ion transference number using GO as filler and application in lithium battery, Ionics 2020, 26, 4299 (IF = 2.961)

19. Chu Yang, Feng Zhang, Guo-Jun Deng, Hang Gong*, Amination of Aromatic Halides and Exploration of the Reactivity Sequence of Aromatic Halides, J. Org. Chem. 2019, 84, 181 (IF₂₀₂₂ = 4.198)

18. Feng Zhang*, Lesong Li, Jingyu Zhang, Hang Gong*, Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions, Sci. Rep. 2019, 9, 2787.  (IF₂₀₁₉ = 3.998)

17. Feng Zhang*, Lesong Li, Juan Ma, Hang Gong*, MoS₂-Catalyzed transamidation reaction, Sci. Rep. 2019, 9, 2536. (IF₂₀₁₉ = 3.998)

16. Jingxian Fang, ZhiyongPeng, YunYang, Jiawei Wang, JiayingGuo, Hang Gong*, Graphene-Oxide-Promoted Direct Dehydrogenative Coupling Reaction of Aromatics, Asian J. Org. Chem. 2018, 7, 355 (IF = 3.116)

15. Juan Ma, Feng Zhang, Jingyu Zhang, Hang Gong*, Cobalt(II)-Catalyzed N-Acylation of Amines through a Transamidation Reaction, Eur. J. Org. Chem. 2018, 2018, 4940. (IF = 3.261)

14. Juan Ma, Jingyu Zhang, Hang Gong*, Mn(II)-Catalyzed N-Acylation of Amines, Synthesis 2019, 51, 693. (IF = 2.969)

13. Jingyu Zhang, Shiguang Li, Guo-Jun Deng, Hang Gong*, Metal-free, Oxidant-free, and Controllable Graphene Oxide Catalyzed Direct Iodination of Aromatics and Ketones, ChemCatChem 2018, 10, 376 (IF = 5.497)

12. Jingxian Fang, Dangui Wang, Guo-Jun Deng, Hang Gong*, Transition metal-free protodecarboxylation of electron rich aromatic acids under mild conditions, Tetrahedron Lett. 2017, 58, 4503. (IF = 2.032)

11. Jingyu Zhang, Yun Yang, Jingxian Fang, Guo-Jun Deng, Hang Gong*, Metal-free, Initiator-free Graphene Oxide Catalyzed Trifluoromethylation of Arenes, Chem.-An Asian J. 2017, 12, 2524. (IF = 4.839)

10. Yun yang, Lijuan Zhang, Guo-Jun Deng, Hang Gong*, Simple, Efficient and Controllable Synthesis of Iodo/Di-iodoarenes via Ipsoiododecarboxylation/Consecutive Iodination Strategy, Sci. Rep. 2017, 7, 40430. (IF₂₀₁₇ = 4.122)

9. Huiying Zeng*, Pan Pan, Jinping Chen, Hang Gong*, Chao-Jun Li*, :C-C Bond Formation via Oxidative Ring-opening Homo-coupling of Cyclobutanol, Eur. J. Org. Chem. 2017, 1070. (IF = 3.261)

8. Hailong Zhang, Guo-Jun Deng, Shiguang Li, Chao-Jun Li*, Hang Gong*, Non-symmetrical Diarylcarboxylic Acids via Rhodium(I)-catalyzed Regiospecific Cross-dehydrogenation Coupling of Aromatic Acids: Twofolds Direct C–H Bond Activations in Water, RSC Adv. 2016, 6, 91617. (IF = 4.036)

7. Shiguang Li, Xi Chen, Jinping Chen, Hang Gong*, Ionic Liquid-Promoted Copper(II)-Catalyzed Homocoupling of Terminal Alkynes in Aqueous Phase or under Solvent-Limited Conditions, Bull. Chem. Soc. Jpn. 2016, 89, 794. (IF = 5.121)

6. Xi Chen, Hailong Zhang, Jinping Chen, Hang Gong*, A Mild CuCl-catalyzed Glaser-type Homocoupling Reaction: Air Oxidation and Room Temperature, Chem. Lett. 2015, 44, 129. (IF = 1.715)

5. Hang Gong*, Chang-Qun Cai, Nian-Fa Yang, Li-Wen Yang, Jin Zhang, Qing-Hua Fan. Application of non-imidazolium-based ionic liquid in the Baylis-Hillman reactions: Rate and yield promoted, J. Mol. Chem A: Chem. 2006, 249, 236 (IF = 5.008)

4. Hang Gong, Nian-Fa Yang*, Guo-Jun Deng, and Guang-Yi Xu. An eco-friendly, convenient, and practical conversion of arylamines to oxazolidinones, Chem. Lett. 2009, 38, 584. (IF = 1.715)

3. Nian-Fa Yang*, Hang Gong, Wei-Jun Tang, Qing-Hua Fan, Chang-Qun Cai and Li-Wen Yang. Phase selectively soluble dendritic derivative of 4-(N,N-dimethylamino) pyridine: An easily recyclable catalyst for Baylis-Hillman reactions, J. Mol. Chem A: Chem. 2005, 233, 55. (IF = 5.008)

2. Hang Gong, Nian-fa Yang*. A convenient method for the synthesis of 2-oxazolidinones from ethylene carbonate and primary aryl amines, Heterocycles 2009, 78, 2093. (IF = 0.689)

1. Hang Gong, Nian-Fa Yang*, Li-Wen Yang, Guo-Jun Deng, Ji Liu, and Yong-Feng Luo. Chiral ligand controlled helix-sense-selective atom transfer radical polymerization of 1-phenyldibenzosuberyl methacrylate, Chem. Lett. 2011, 40, 651. (IF = 1.715)

授权专利：

9. 龚行，李增全，赵御含，蔡昌群，一种温和条件下氧引发烯经双功能化合成β-羟基砜衍生物的方法，中国发明专利，ZL 202210649076.1专利授权日期：2024/01/02

8. 龚行，何敏，王敏，蔡昌群，一种苯并异噻唑类化合物及其制备方法，中国发明专利，ZL 202110546162.5专利授权日期：2022/12/23

7. 龚行，赵御含，李乐松，一种基于铁催化的酮酸脱羧、脂肪醛脱羰的自由基-自由基偶联反应制备芳基酮的方法，中国发明专利，ZL 201911169563.2，专利授权日期：2022/10/14

6. 龚行，孟霞，王燕洁，蔡昌群，在温和条件下合成β-酮砜衍生物的方法及所得β-酮砜衍生物，中国发明专利，ZL 202110579546.7，专利授权日期：2022/09/09

5. 龚行，蔡昌群，杨蕴，一种基于芳烃羧酸脱羧反应合成单碘代芳烃或二碘代芳烃的方法，中国发明专利，ZL 201611028481.2，专利授权日期：2020/06/05

4. 龚行，谢桂林，蔡昌群，张景雨，一种氧化石墨烯催化甲酰化反应合成甲酰胺衍生物的方法，中国发明专利，ZL 201711206076.X，专利授权日期：2020/01/10

3. 龚行，谢桂林，蔡昌群，马娟，一种钼催化甲酰化反应合成甲酰胺衍生物的方法，中国发明专利，ZL 201711207803.4，专利授权日期：2020/03/13

2. 龚行，谢桂林，蔡昌群，马娟，一种钴催化甲酰化反应合成甲酰胺衍生物的方法，中国发明专利，ZL 201711206078.9，专利授权日期：2019/12/13

1. 龚行，尹嘉雯，蔡昌群，一种无催化剂参与的转胺反应制备甲酰胺衍生物的方法，中国发明专利，ZL 201811327786.2，专利授权日期：2021/08/06

主持教学改革项目

1.湖南省教育教学改革课题，环境友好型有机化学实验教学新模式探索，2022/01-2023/12

2.湖南省学位与研究生教育教学改革研究课题，适应创新能力培养的化学专业研究生实验室管理改革与实践，2016/01-2018/12

主讲课程

本科生课程《有机化学》《有机化学实验》

研究生课程《现代有机合成》