2024年6月19日，Elsevier 旗下top期刊《Carbohydrate Polymers》（影响因子：11.2）在线发表了云南师范大学化学与化工学院赵焱教授课题组最新研究成果《Reactive oxygen species responsive chitooligosaccharides based nanoplatform for sonodynamic therapy in mammary cancer》。云南师范大学化学化工学院为第一作者单位，赵焱教授、何俊男、晏瑾为通讯作者。

https://www.sciencedirect.com/science/article/pii/S0144861724006295

Abstract

Sonodynamic therapy (SDT) has been extensively studied as a new type of non-invasive treatment for mammary cancer. However, the poor water solubility and defective biocompatibility of sonosensitizers during SDT hinder the sonodynamic efficacy. Herein, a nanoplatform has been developed to achieve high efficient SDT against mammary cancer through the host-guest interaction of β-cyclodextrin/5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (β-CD-TPP) and ferrocenecarboxylic acid/chitooligosaccharides (FC-COS). Moreover, the glucose oxidase (GOx) was loaded through electrostatic adsorption, which efficiently restricts the energy supply in tumor tissues, thus enhancing the therapeutic efficacy of SDT for tumors. Under optimal conditions, the entire system exhibited favorable water solubility, suitable particle size and viable biocompatibility. This facilitated the integration of the characteristics of starvation therapy and sonodynamic therapy, resulting in efficient inhibition of tumor growth with minimal side effects in vivo. This work may provide new insights into the application of natural oligosaccharides for construct multifunctional nanocarrier systems, which could optimize the design and development of sonodynamic therapy strategies and even combination therapy strategies.

扩展阅读：

赵焱-云南师范大学化学化工学院

云师大化工学院赵学博士在top期刊《Chemical Engineering Journal》发表最新研究成果

云师大化工学院赵学博士在top期刊《Chemical Engineering Journal》发表最新研究成果

云南师范大学赵焱课题组MCP:超分子自组装纳米载体用于细胞

化学化工学院

赵焱                                                

分析化学专业，教授，博士（硕士生）导师

联系方式：zhaooyann@163.com

学术任职及兼职

1.亚太环糊精协会委员

2.云南省高等学校药学类专业教学指导委员会委员

主要研究方向

超分子药物化学；超分子功能纳米材料

主要招生专业

有机化学；分析化学；生物与医药

教育与工作经历:

2008年08月至今，云南师范大学化学化工学院，教授

1996年07月～2008年08月，云南师范大学化学化工学院，助教、讲师、副教授

2000年09月～2001年07月，南开大学超分子化学课题组，访问学者

1993年09月～1996年07月，云南大学分析化学专业，硕士

1989年09月～1993年07月，云南师范大学应用化学专业，学士

获奖成果和荣誉称号：

1. 赵焱. 云南省科技副总，2023年

2. 赵焱. 云南省政府特殊津贴，2016年

3. 赵焱. 云南省中青年学术与技术带头人，2015年

4. 赵焱，赵勇，迟绍明. 新型桥联和多胺修饰环糊精的合成及其在分子识别中的应用，云南省科学技术奖（自然科学奖类）三等奖，2014年

5. 赵焱. 云南师范大学红云园丁奖一等奖，2021年

6. 赵焱. 云南师范大学伍达观教育基金奖教金二等奖，2009年

主持科研项目

1. 国家自然科学基金项目，新型多电荷环糊精对昆明山海棠中活性分子的键合、组装与可控释放，执行时间：2020/01-2023/12

2. 国家自然科学基金项目，三七中抗癌活性皂苷元的超分子体系构筑及与牛血清蛋白相互作用研究，执行时间：2014/01-2017/12

3. 国家自然科学基金项目，新型桥联环糊精/DABO类HIV逆转录酶抑制剂包结配合物的超分子体系研究，执行时间：2011/01-2013/12

4. 云南省高校超分子生物医用材料科技创新团队，2024. 04

5. 云南省高校生物传感与纳米技术硕士生导师团队，2023.11

6. 企业横向项目，基于超分子凝胶的稀土回收技术研发，执行时间：2023/09-2026/09

7. 企业横向项目，超分子主体化合物对稀土元素的吸附作用研究，执行时间：2022/03-2025/02

8. 企业横向项目，超分子复合乳化剂的研发，执行时间：2021/10-2024/09

9. 企业横向项目，水溶性维生素K2（35）包埋技术的研发，执行年限：2017/12-2020/12

10.  云南省基础研究计划项目， 新型桥联环糊精为荧光探针的分子多重识别研究，执行时间：2009/01-2011/12

11. 云南省第九批中青年学术和技术带头人后备人才项目，执行时间：2009/01-2013/12

12. 云南省自然科学基金，芳香二胺桥联环糊精的分子协同识别研究，执行时间：2003/09-2005/12

代表性论文、专利等

1.Yue-Long Liu, Meng-Shan Chen, Xue Zhao*, Haoran Zhang, Yan Zhao*, Ying-Tang Zhou*. Unlocking the potential of sub-nanometer-scale copper via confinement engineering: A remarkable approach for electrochemical nitrate-to-ammonia conversion in wastewater treatment. Chemical Engineering Journal 2023, DOI: 10.1016/j.cej.2023.146176.

2. Yue-Long Liu, Hao-Ran Zhang, Xue Zhao* Rui Bai, Hai-Jian Wang, Yan Zhao*, Ying-Tang Zhou*. Two-dimensional peak-valley alternating self-supporting electrode accelerating nitrate electrocatalytic reduction: Ammonia synthesis and wastewater treatment. Chemical Engineering Journal. 2024,485,149876. Doi.org/10.1016/j.cej.2024.149876.

3.Shuai Chen, Fang-Dao Zhu, Zheng-Quan Nie, Cui-Ting Yang, Jian-Mei Yang, Jun-Nan He, Xiao-Ping Tan, Xiao-Qing Liu, Jin Zhang*, Yan Zhao*. pH-Activatable Charge-Reversal Polymer-Based Nanocarriers for Targeted Delivery of Antihepatoma Compound. Langmuir 2023, 39, 38, 13588–13598.

4.Jin-Kui Teng, Lu-Lu Yue, Bi-Lian Li, Jian-Mei Yang, Cui-Ting Yang, Tong Yang, Xiang-Ye Zhi, Xiao-Qing Liu, Yan Zhao*, Jin Zhang*. Synthesis of cyclodextrin‐ased temperature/enzyme‐r esponsive nanoparticles and application in antitumor drug delivery. Journal of Molecular Structure 2023, 1274, 134596.

5.Shuai Chen, Zheng-Quan Nie, Fang-Dao Zhu, Cui-Ting Yang, Jian-Mei Yang, Jun-Nan He, Xiao-Qing Liu, Jin Zhang*, Yan Zhao*. Facile Fabrication of Dual-Activatable Gastrointestinal-Based Nanocarriers for Safe Delivery and Controlled Release of Methotrexate. ChemPlusChem 2023, e202300387.

6.Jun-Xin Xu, Si-Ling Chen, Jian-Mei Yang, Zheng-Quan Nie, Jun-Nan He, Yong Zhao, Xiao-Qing Liu, Jin Zhang*, Yan Zhao*. Hyaluronidase-trigger nanocarriers for targeted delivery of anti-liver cancer compound. RSC Advances 2023, 13 (16), 11160-11170.

7.Bi-Lian Li, Jin-Kui Teng, Shuai Chen, Jian-Mei Yang, Xiao-Qing Liu, Jin Zhang*, Yan Zhao*. A dual-stimuli responsive supramolecular nanovector anchoring folic acid ligands for targeted delivery of anti-colorectal drug hydroxycamptothecin. Journal of Applied Polymer Science 2023, 140 (8), e53525.

8.Ling-Li Wang, Teng-Teng Shan, Lu Pu, Jin Zhang, Rong Hu, Yun-Hui Yang, Jian-Mei Yang*, Yan Zhao*. Glucometer-based electrochemical biosensor for determination of microRNA (let-7a) using magnetic-assisted extraction and supersandwich signal amplification. Microchimica Acta 2022, 189 (12), 444.

9.Bi-Lian Li, Jin Zhang, Wen Jin, Xiang-Yu Chen, Jian-Mei Yang, Shao-Ming Chi, Qiong Ruan, Yan Zhao*. Oral administration of pH-responsive polyamine modified cyclodextrin nanoparticles for controlled release of anti-tumor drugs. Reactive and Functional Polymers 2022, 172, 105175.

10.Ling-Li Wang, Hui-Wen Yang, Fang-Dao Zhu, Shao-Ming Chi, Jin Zhang, Jian-Mei Yang*, Yan Zhao*. Host-guest inclusion systems of two bioactive natural products derivantives and three polyamine-modified β-cyclodextrins: Preparation, characterization, biological activity. Journal of Drug Delivery Science and Technology 2022, 67, 102940.

11.Bi-Lian Li, Chun-Lei Wang, Qin Wang, Jian-Mei Yang, Shao-Ming Chi, Jian-Chong Chen, Jin Zhang*, Yan Zhao*. β-Cyclodextrin-based supramolecular nanoparticles: pH-sensitive nanocarriers for the sustained release of anti-tumor drugs. New Journal of Chemistry 2022, 46 (45), 21823-21833.

12.Jin Zhang, Si-Ling Chen, Jin-kui Teng, Bi-Lian Li, Ling-Li Wang, Jian-Mei Yang, Yan Zhao*. Self‐Assembled Nanovehicle for Intracellular Enzyme‐Triggered Antitumor Drug Release. Macromolecular Chemistry and Physics 2022, 223 (10), 2200028.

主持教学改革项目

1.国家级一流本科专业建设点，化学，2021年

2.国家级一流本科社会实践课程，制造类产品创业实践，2023年

3.教育部产学合作协同育人项目，虚实结合的“专创融合”实践平台建设，2021年

主讲课程

本科生课程《分析化学》《仪器分析》《药物分析实验》《仪器分析实验》《制造类产品创业实践》

研究生课程《分离科学》