主要研究领域

微核（Micronucleus）的起源、命运及其病理/生理结果，包括PS1突变诱发阿尔兹海默病的机制研究、Y染色体丢失的诱因及其生理/病理学影响的研究、微营养物质对人类基因组稳定性的维护作用、药食两用植物化合物对人基因组稳定性的影响及其机制探究。累计主持国家自然科学基金2项，省部级基础科学研究计划2项。以第一作者或通讯作者在Aging Research Reviews、Human Genetics、International Journal of Cancer、Mutation Research Reviews、浙江大学学报（医学版）等国内外学术期刊发表学术论文20余篇。2019年获评云南师范大学优秀青年学者, 2021年获云南省自然科学二等奖（排名第3）。

学术任职及兼职：

2022．08-至今，任Frontiers in Aging杂志Genetics, Genomics and Epigenomics of Aging版块的副主编（Associate Editor）

近三年代表论文和奖励：

*：通讯作者

（1） Xihan Guo*, Henning Hintzsche*, Weijiang Xu, Juan Ni, Jinglun Xue, Xu Wang*. Interplay of cGAS with micronuclei: regulation and diseases. Mutation Research/Reviews in Mutation Research, 2022, 790: 108440.

（2） Ting Lyu, Hongyuan Zhou, Yihui Wang, Minyan Jiang, Qian Tao, Juanlin Chen, Yitong Guo, Qiuping Zhang, Xu Wang, Xihan Guo*. High-dose metformin induces a low-glucose dependent genotoxic stress. Food and Chemical Toxicology, 2022, 165: 113129.

（3） 张城，汪旭，郭锡汉*，免疫原性微核的起源与生物医学意义，生命科学，2022, 34: 392-400.

（4） Jianfei Li, Cheng Zhang, Lingzhi Li, Xueqin Hu, Yizhen Jia, Yanan Huang, Ting Lyu, Xu Wang, Xihan Guo*. Folate deficiency enhances the in vitro genotoxicity of bile acids in human colon and liver cells. Mutagenesis, 2022, 37: 34-43.

（5） Xihan Guo*. Loss of Y chromosome at the interface between aging and Alzheimer’s disease. Cellular and Molecular Life Sciences, 2021, 78 (21), 7081-7084.

（6） Xihan Guo*, Yanmei Qi, Jianfei Li, Houhong Fan, Limei Yang, Xue Wu, Juan Ni, Han Wang, Xu Wang*. A comprehensive study of the genotoxic and anti-genotoxic effects of homocysteine in HUVECs and mouse bone marrow cells. Food and Chemical Toxicology, 2021, 156: 112518.

（7） Xihan Guo*, Jianfei Li, Jinglun Xue, Michael Fenech*, Xu Wang*. Loss of Y chromosome: An emerging next-generation biomarker for disease prediction and early detection? Mutation Research/Reviews in Mutation Research, 2021, 788: 108389.

（8） Xueqin Dai, Xihan Guo*. Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations Ageing Research Reviews, 2021, 68: 101342.

（9） Xihan Guo, Xueqin Dai, Xue Wu, Neng Cao, Xu Wang*. Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes. International Journal of Cancer, 2021, 148(4): 812-824.

（10） Xihan Guo, Chunlei Wang, Weimeng Tian, Xueqin Dai, Juan Ni, Xiayu Wu, Xu Wang*. Extract of bulbus of Fritillaria cirrhosa induces spindle multipolarity in human-derived colonic epithelial NCM460 cells through promoting centrosome fragmentation. Mutagenesis, 2021, 36 (1): 95-107.

（11） Ling Yan, Ziru Zhao, Xiaoran Wang, Ting Lyu, Jianfei Li, Yanmei Qi, Xu Wang, Xihan Guo*. Short-term in vitro glutamine restriction differentially impacts the chromosomal stability of transformed and non-transformed cells. Mutagenesis, 2020, 35 (5): 425-435

（12） 严敏、汪旭、郭锡汉*. 早老蛋白 1 功能缺失性突变导致家族性阿尔茨海默病的研究进展. 浙江大学学报（医学版），2020，49 (4): 487-499.

（13） Xihan Guo, Xueqin Dai, Xue Wu, Tao Zhou, Juan Ni, Jinglun Xue, Xu Wang*. Understanding the birth of rupture-prone and irreparable micronuclei. Chromosoma, 2020,129 (3): 181-200.

（14） Xihan Guo, Xueqin Dai, Tao Zhou, Han Wang, Juan Ni, Jinglun Xue, Xu Wang*. Mosaic loss of human Y chromosome: what, how and why. Human Genetics, 2020, 139 (4), 421-446.

（15） Xihan Guo, Xiayu Wu, Juan Ni, Ling Zhang, Jinglun Xue, Xu Wang*. Aqueous extract of bulbus Fritillaria cirrhosa induces cytokinesis failure by blocking furrow ingression in human colon epithelial NCM460 cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2020, 850: 503147.

（16） Xihan Guo, Xueqin Dai, Juan Ni, Xiaoling Ma, Jinglun Xue, Xu Wang*. Geraniin differentially modulates chromosome stability of colon cancer and noncancerous cells by oppositely regulating their spindle assembly checkpoint. Environmental and molecular mutagenesis, 2019, 60(3), 254-268.

（17） Xihan Guo, Xueqin Dai, Juan Ni, Neng Cao, Guofang Yang, Jinglun Xue, Xu Wang*. High concentration of sugars is genotoxic to folate-deficient cells. Mutation Research/Fundamental and Molecular mechanisms of Mutagenesis, 2019, 814, 15-22.

（18） Xihan Guo, Juan Ni, Ziqing Liang, Jinglun Xue, Michael F Fenech, Xu Wang*. The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem. Mutation Research/Reviews in Mutation Research, 2019, 779, 1-35.

（19） 汪旭，倪娟，郭锡汉，王晗，周滔，2021年云南省自然科学二等奖

近三年主持的国家级和省部级科研项目：

1． 国家自然科学基金青年基金.免疫原性微核激活cGAS-STING通路并影响PS1突变诱导Aβ形成的机制研究，25万，2020.01–2022.12.

2． 国家自然科学基金地区基金.利用小鼠模型研究Y染色体丢失对阿尔茨海默病的影响及分子机制，33万，2023.01-2026.12.

3． 云南省基础研究计划青年项目，PS1突变通过激活L1逆转录转座子诱导人神经细胞固有免疫的机制研究，5万，2020.06–2023.05.

4． 云南省基础研究计划面上项目，免疫原性微核介导的cGAS-STING-IRF3信号轴在二甲双胍抗癌活性中的作用探究，10万，2021.04–2024.03.

近三年主讲课程（研究生，本科）：

硕士生课程：现代生物技术研究方法。

本科生课程：分子生物学、遗传学、生物科学专业英语、看得见的基因、环境-遗传互作与健康结局分析技术。