2024年2月22日，ACS旗下国际著名期刊《Analytical Chemistry 》在线发表了云南师范大学能源与环境科学学院​张勇教授课题组的最新研究成果《Europium Metal–Organic Framework with a Tetraphenylethylene-Based Ligand: A Dual-Mechanism Quenching Immunosensor for Enhanced Electrochemiluminescence via the Coordination Trigger》。云南师范大学能源与环境科学学院​张勇教授为通讯作者。合作单位为济南大学魏琴教授课

Abstract

The effective applications of electrochemiluminescence (ECL) across various fields necessitate ongoing research into novel luminophores and ECL strategies. In this study, self-luminous flower-like nanocomposites (Eu-tcbpe-MOF) were prepared by coordination self-assembly using the aggregation-induced emission material 1,1,2,2-tetrakis(4-carboxyphenyl)ethylene (H4TCBPE) and Eu(III) ions as the precursors. Compared with the monomers and aggregates of H4TCBPE, Eu-tcbpe-MOF exhibits stronger ECL emission. Such enhanced electrochemiluminescence is due to coordination as the coordination-triggered electrochemiluminescence (CT-ECL) enhancement effect. In this study, a cubic-structured nanocomposite (Co9S8@Au@MoS2) was used as an efficient quencher, and a more sensitive ECL detection platform was achieved by two quenching mechanisms: resonance energy transfer and competitive consumption of coreactants. N,N-Diethylethanolamine (DBAE) was used as a coreactant, and DBAE has a faster electron transfer rate and stronger energy supply efficiency than the traditional anodoluminescent coreactant tripropylamine, which effectively improves the ECL signal intensity of Eu-tcbpe-MOF. Hence, a sandwich-type ECL immunosensor was prepared by employing a dual-quenching mechanism, utilizing Eu-tcbpe-MOF as the detection probe and Co9S8@Au@MoS2 as the quencher, achieving precise detection of carcinoembryonic antigen from 0.1 pg·mL–1 to 100 ng·mL–1 with a detection limit of 35.1 fg·mL–1.

扩展阅读：

云师大能环学院张勇课题组在国际top期刊《Sensors and Actuators B: Chemical》发表

张勇教授入职云南师范大学

https://solar.ynnu.edu.cn/info/1187/3112.htm

张勇

  材料科学与工程，教授，博士生导师

联系方式：

   yongzhang7805@126.com

主要招生专业：

  农业工程、农业工程与信息技术

主要研究方向：

  1.电分析化学传感器件的制备及在食品、环境分析和疾病检测中的应用

  2.光催化降解农林污染物

  3.农业生物质废弃物低碳转化利用及生态效益评估

  4.生态农业绿色防控技术及应用

学历及研究简历：

        1997年09月-2001年07月，济南大学，本科生，应用化学专业；

        2003年09月-2005年12月，南京工业大学，硕士研究生，应用化学专业

        2012年09月-2016年06月，北京理工大学，博士研究生，材料科学与工程专业

        2016年08月-2021年12月，济南大学，副教授

        2016年10月-2018年10月，济南大学，博士后

        2018年12月-2020年12月，美国国立卫生研究院（National Institutes of Health），博士后

        2022年01月-2022年12月，云南师范大学，副教授

        2023年01月至今，云南师范大学，教授

近三年代表论文和著作：

        1.  Bing Li, Yunxiao Li, Chenchen Li, Jinghui Yang, Deling Liu, Huabin Wang, Rui Xu, Yong Zhang* and Qin Wei. An Ultrasensitive Split-Type Electrochemical Immunosensor Based on Controlled-Release Strategy for Detection of CA19-9. Biosensors and Bioelectronics, 2023, https://doi.org/10.1016/j.bios.2023.115180. (SCI Q1，IF = 12.545)

        2.  Zhengfang Qu, Yunxiao Li, Rui Xu, Chenchen Li, Huan Wang, Huabin Wang, Yong Zhang* and Qin Wei. Candy-like heterojunction nanocomposite of WO₃/Fe₂O₃ based semiconductor gas sensor for the detection of triethylamine. Microchimica Acta, 2023. (SCI Q1，IF = 6.408)

        3.  Chenchen Li, Yunxiao Li, Yong Zhang*, Guanhui Zhao*, Yaoguang Wang, Huabin Wang, Huan Wang, Rui Xu*, Qin Wei. Signal-enhanced electrochemiluminescence strategy using iron-based metal-organic frameworks modified with carboxylated Ru(II) complexes for neuron-specific enolase detection. Biosensors and Bioelectronics, 2022, 215:114605.  (SCI Q1，IF = 12.545)

        4.  Yingying Zhang, Tingting Wu, Deling Liu, Rui Xu, Hongmin Ma*, Qin Wei and Yong Zhang*. Photoelectrochemical immunosensor for the sensitive detection of neuron-specific enolase based on the effect of Z-scheme WO₃/NiCo₂O₄ nanoarrays p-n heterojunction. Biosensors and Bioelectronics, 2022, 213:114452. (SCI Q1，IF = 12.545)

        5.  Yunxiao Li, Rui Xu*, Huabin Wang, Wumei Xu, Liyan Tian, Jingxin Huang, Chengyue Liang and Yong Zhang*. Recent Advances of Biochar-Based Electrochemical Sensors and Biosensors. Biosensors, 2022, 12: 377. (SCI Q1，IF = 5.743)

        6.  Yong Zhang*, Deling Liu, Yingying Zhang, Yanrong Qian, Chenchen Li, Zhengfang Qu, Rui Xu, Qin Wei. Highly sensitive photoelectrochemical neuron specific enolase analysis based on cerium and silver Co-Doped Sb₂WO₆. Biosensors and Bioelectronics, 2022, 203: 114047. (SCI Q1，IF = 12.545)

        7.  Yong Zhang*, Haonan Yang, Yanbao Yu*, and Ying Zhang*. Application of nanomaterials in proteomics-driven precision medicine. Theranostics. 2022, 12(6): 2674-2686. (SCI Q1，IF = 11.600)

        8.  Yunxiao Li, Jiwei Xu, Rongqi Cheng, Jinghui Yang, Chenchen Li, Yingchun Liu, Rui Xu, Qin Wei and Yong Zhang*, A robust molecularly imprinted electrochemiluminescence sensor based on a Ni-Co nanoarray for the sensitive detection of spiramycin. Analyst, 2022, 147(22): 5178-5186. (SCI Q1，IF = 5.227)

        9.  Yingying Zhang, Jingjing Chen, Hui Wang, Qianqian Cui, Wei Da, Yong Zhang, Xiang Ren, Hongmin Ma*, Qin Wei and Huangxian Ju. Novel Photoelectrochemical Biosensing Platform Based on a Double Type II CdLa₂S₄/SnIn₄S₈/Sb₂S₃ Ternary Heterojunction as Photoactive Materials and NiCo₂O₄ Nanospheres as a Photoquencher for CA19-9 Detection. Analytical Chemistry, 2022, 94(45): 15915-15923. (SCI Q1，IF = 8.008)

        10.  Huabin Wang, Ting Cui, Dingxiang Chen, Qiong Luo, Jiwei Xu, Rong Sun, Wenhua Zi, Rui Xu*, Ying Liu* and Yong Zhang*. Hexavalent chromium elimination from wastewater by integrated micro-electrolysis composites synthesized from red mud and rice straw via a facile one-pot method. Scientific Reports, 2022,12: 14242. (SCI Q2，IF = 4.996)

        11.  Bing Li, Yong Zhang*, Xiang Ren, Yuyang Li, Huan Wang, Hongmin Ma, Dan Wu, and Qin Wei. A No-washing Point-of-care Electrochemical Biosensor Based on CuS Nanoparticles for Rapid and Sensitive Detection of Neuron-specific Enolase. Electroanalysis, 2022, 34(2): 338-344. (SCI Q3，IF = 3.077)

        12.  Chenchen Li, Jinghui Yang, Rui Xu, Huan Wang*, Yong Zhang* and Qin Wei. Progress and Prospects of Electrochemiluminescence Biosensors Based on Porous Nanomaterials. Biosensors, 2022, 12: 508. (SCI Q1，IF = 5.743)

        13.  Yaoguang Wang, Yingying Wang, Fangzheng Wang, Hong Chi, Guanhui Zhao, Yong Zhang, Tianduo Li and Qin Wei. Electrochemical aptasensor based on gold modified thiol graphene as sensing platform and gold-palladium modified zirconium metal-organic frameworks nanozyme as signal enhancer for ultrasensitive detection of mercury ions. Journal of Colloid and Interface Science, 2022, 606: 510-517. (SCI Q1，IF = 9.965)

        14.  Xianzhen Song, Tingting Wu, Chuannan Luo, Lu Zhao, Xiang Ren, Yong Zhang* and Qin Wei. Peptide-Based Electrochemiluminescence Biosensors Using Silver Nanoclusters as Signal Probes and Pd-Cu₂O Hybrid Nanoconcaves as Coreactant Promoters for Immunoassays. Analytical Chemistry, 2021, 93(38): 13045-13053. (SCI Q1，IF = 8.008)

        15.  Deling Liu, Yanrong Qian, Rui Xu, Yong Zhang*, Xiang Ren, Hongmin Ma and Qin Wei. A dual-signal amplification photoelectrochemical immunosensor for ultrasensitive detection of CYFRA 21-1 based on the synergistic effect of SnS₂/SnS/Bi₂S₃ and ZnCdS@NPC-ZnO. Sensors and Actuators B: Chemical, 2021, 346: 130456. (SCI Q1，IF =9.221)

        16.  Yong Zhang*, Zhaoyi Liu, Yaoguang Wang, Xuan Kuang, Hongmin Ma and Qin Wei. Directly assembled electrochemical sensor by combining self-supported CoNnanoarray platform grown on carbon cloth with molecularly imprinted polymers for the detection of Tylosin. Journal of Hazardous Materials. 2020, 398: 122778. (SCI Q1，IF =14.224)

        17.  Bing Li, Yong Zhang*, Xiang Ren, Hongmin Ma, Dan Wu and Qin Wei. No-wash point-of-care biosensing assay for rapid and sensitive detection of aflatoxin B1. Talanta, 2021, 235: 122772. (SCI Q1，IF =6.556)

        18.  Rongqi Cheng, Yulong Ding, Yaoguang Wang, Huan Wang, Yong Zhang*, and Qin Wei*. A novel molecularly imprinted electrochemiluminescence sensor based on cobalt nitride nanoarray electrode for the sensitive detection of bisphenol S. RSC Advances, 2021, 11: 11011. (SCI Q2，IF =4.036)

        19.  Zhaoyi Liu, Tao Fan, Yong Zhang*, Xiang Ren, Yaoguang Wang, Hongmin Ma and Qin Wei. Electrochemical assay of ampicillin using Fe₃N-Co₂N nanoarraycoated with molecularly imprinted polymer. Microchimica Acta, 2020, 187: 442. (SCI Q1，IF = 6.408)

        20.  Zhaoyi Liu, Yong Zhang*, Bing Li, Xiang Ren, Hongmin Ma and Qin Wei*. Novel ratiometric electrochemical sensor for no-wash detection offluorene-9-bisphenol based on combining CoN nanoarrays with molecularly imprinted polymers. Analyst, 2020, 145: 3320-3328. (SCI Q1，IF = 5.227)

        21.  Dahai Liu, Zijian Zhou, Xinyu Wang, Hongzhang Deng, Lin Sun, Haixin Lin, Fei Kang, Yong Zhang, Zhantong Wang, Weijing Yang, Lang Rao, Kuikun Yang, Guocan Yu, Jianshi Du, Zheyu Shen and Xiaoyuan Chen. Yolk-shell nanovesicles endow glutathione-responsive concurrent drug release and T-1 MRI activation for cancer theranostics. Biomaterials, 2020, 244: 119979. (SCI Q1，IF = 15.304)

        22.  Yong Zhang* and Xiaoyuan Chen*. Nanotechnology and nanomaterial-based no-wash electrochemical biosensors: from design to application. Nanoscale. 2019, 11: 19105. (SCI Q1，IF =8.307)

        23.  Zhaoyi Liu, Yong Zhang*, Jinhui Feng, Qingzhi Han and Qin Wei. Ni(OH)₂ nanoarrays based molecularly imprinted polymer electrochemical sensor for sensitive detection of sulfapyridine. Sensors and Actuators B: Chemical, 2019, 287: 551-556. (SCI Q1，IF =9.221)

        24.  Yaoguang Wang, Guanhui Zhao, Yong Zhang*, Bin Du and Qin Wei. Ultrasensitive photoelectrochemical immunosensor based on Cu doped TiO₂ compositing with carbon nitride for detection of carcinoembryonic antigen. Carbon, 2019, 146: 276-283. (SCI Q1，IF = 11.307)

近五年获奖成果和荣誉称号：

  河北省科技进步奖，二等奖（2019年，排名第二）

  山东省省级教学成果奖, 特等奖（2018年，排名第三）

  山东高等学校优秀科研成果奖，一等奖（2018年，排名第三）

  中国分析测试协会科学技术奖，青年奖（2017年）

  山东高等学校科学技术奖，二等奖（2017年，排名第一）

  山东省优秀学士学位论文，指导教师（2017年）

  第四届山东省大学生科技创新大赛，二等奖，指导教师（2017年）

  第十五届“挑战杯”海尔山东省大学生课外学术科技作品竞赛，二等奖，指导教师（2017年）

近三年主持的国家级或百万以上其他项目：

  国家自然科学基金面上项目，64 万元，2018.01-2021.12，主持人

  国家自然科学基金地区基金，33 万元，2023.01-2026.12，主持人

近三年主持的教学教改及省级以上教学质量工程：

        2018年，山东省高校优秀教学成果奖，特等奖（第三位）

近三年主讲课程（研究生、本科生）：

  《食品安全与分析》、《食品化学》、《功能纳米材料》、《生物质能源工程》