博文
云南师范大学杰出校友之牛昱宇教授
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牛昱宇，男，汉族，1977年2月生，教授，博士生导师，长期从事灵长类基因编辑与胚胎发育方向的研究，中国遗传学会基因组编辑分会委员，
教育部大长江。1999年毕业于云南师范大学生命科学学院生物系。
一、学历及工作经历
1995-1999 云南师范大学生物系，生物学，学士
2001-2007 中国科学院昆明动物研究所，动物学，博士
2006-2008，德国柏林野生与笼养动物研究所，访问学者
2007-2014 中国科学院昆明动物研究所，副研究员
2014-至今 昆明理工大学灵长类转化医学研究院，副院长，教授，博士生导师
2019-至今 昆明理工大学生命科学与技术学院，院长，教授，博士生导师
2022.10--任昆明理工大学副校长。
二、开设课程
《细胞工程》、《发育生物学》、《生物学学科前沿讲座》
三、研究领域
灵长类基因编辑
灵长类胚胎发育与疾病
早期胚胎发育是哺乳动物生命发生的重要阶段，这一时期的关键生物学事件，如合子基因启动，表观遗传维持与重建，胚层分化和器官形成等等，是发育生物学的重要基础理论，又和人类健康和疾病密切相关。然而，我们对其中的诸多科学问题却知之甚少。本实验室结合灵长类早期胚胎（体外受精，单性生殖和体细胞核移植）培养，基因编辑，干细胞与示踪，单细胞组学和灵长类疾病动物模型等技术体系，系统研究灵长类细胞多能性的维持与重建，表观遗传维持与胚层分化的关系，退行性疾病的早期诊断和干预等等重要科学问题，以期揭示人类生命发生和疾病形成的奥秘。
四、主持项目
1. 国家重点研发计划“干细胞及转化研究”专项项目，2016YFA0101400，靶向基因编辑建立神经系统疾病猴模型及干细胞治疗研究，2016-2012，2915万元，首席科学家。
2. 国家自然科学基金联合重点项目，U1302227，帕金森氏症转基因灵长类动物模型的构建与致病机理研究，2014-2017，210万元，项目负责人
3. 国家重大科学研究计划（973计划），2012CBA01304，神经退行疾病致病机理及转基因动物模型的建立，2012/01-2016/12，420万元，课题负责人。
4. 国家高技术研究发展计划（863计划），2012AA020701，神经退行性疾病灵长类动物模型制备关键技术及利用，2012/01-2015/12，710万元，课题负责人。
5. 国家科技重大专项，2009ZX09501-028，评价抗HCV化学药物疗效和安全性的动物模型，2009/01-2011/12，690万元，已结题，项目负责人。 [1]
四、学术论文
| Authors | Article Title | Source Title | Volume | Issue | Start Page | End Page | Publication Year |
| Zhang, Hui; Li, Jiaming; Yu, Yang; Ren, Jie; Liu, Qiang; Bao, Zhaoshi; Sun, Shuhui; Liu, Xiaoqian; Ma, Shuai; Liu, Zunpeng; Yan, Kaowen; Wu, Zeming; Fan, Yanling; Sun, Xiaoyan; Zhang, Yixin; Ji, Qianzhao; Cheng, Fang; Wei, Peng-Hu; Ma, Xibo; Zhang, Shiqiang; Xie, Zhengwei; Niu, Yuyu; Wang, Yan-Jiang; Han, Jing-Dong J; Jiang, Tao; Zhao, Guoguang; Ji, Weizhi; Izpisua Belmonte, Juan Carlos; Wang, Si; Qu, Jing; Zhang, Weiqi; Liu, Guang-Hui | Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging. | Cell reports | 42 | 11 | 113396 | 113396 | 2023 |
| Niu, Yuyu; Wang, Guifang; Feng, Xianjun; Niu, Hongyi; Shi, Wenrui | Significance of fatty liver index to detect prevalent ischemic heart disease: evidence from national health and nutrition examination survey 1999-2016 | FRONTIERS IN CARDIOVASCULAR MEDICINE | 10 | 2023 | |||
| Wu, Junmo; Kang, Yu; Luo, Xiang; Dai, Shaoxing; Shi, Yuxi; Li, Zhuoyao; Tang, Zengli; Chen, Zhenzhen; Zhu, Ran; Yang, Pengpeng; Li, Zifan; Wang, Hong; Chen, Xinglong; Zhao, Ziyi; Ji, Weizhi; Niu, Yuyu | Long-term in vivo chimeric cells tracking in non-human primate | PROTEIN & CELL | 2023 | ||||
| Xu, Lizhu; Wang, Dan; Zhao, Lu; Yang, Zhengsheng; Liu, Xu; Li, Xinyue; Yuan, Tingli; Wang, Ye; Huang, Tianzhuang; Bian, Ning; He, Yuqun; Chen, Xinglong; Tian, Baohong; Liu, Zexian; Luo, Fucheng; Si, Wei; Gao, Guangping; Ji, Weizhi; Niu, Yuyu; Wei, Jingkuan | C9orf72 poly(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys | NEUROBIOLOGY OF DISEASE | 184 | 2023 | |||
| Zhang, Hui; Li, Jiaming; Yu, Yang; Ren, Jie; Liu, Qiang; Bao, Zhaoshi; Sun, Shuhui; Liu, Xiaoqian; Ma, Shuai; Liu, Zunpeng; Yan, Kaowen; Wu, Zeming; Fan, Yanling; Sun, Xiaoyan; Zhang, Yixin; Ji, Qianzhao; Cheng, Fang; Wei, Peng-Hu; Ma, Xibo; Zhang, Shiqian; Xie, Zhengwei; Niu, Yuyu; Wang, Yan-Jiang; Han, Jing-Dong J.; Jiang, Tao; Zhao, Guoguang; Ji, Weizhi; Belmonte, Juan Carlos Izpisua; Wang, Si; Qu, Jing; Zhang, Weiqi; Liu, Guang-Hui | Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging | CELL REPORTS | 42 | 6 | 2023 | ||
| Gong, Yandong; Bai, Bing; Sun, Nianqin; Ci, Baiquan; Shao, Honglian; Zhang, Ting; Yao, Hui; Zhang, Youyue; Niu, Yuyu; Liu, Lizhong; Zhao, Hu; Wu, Hao; Zhang, Lei; Wang, Tianxiang; Li, Shangang; Wei, Yulei; Yu, Yang; Orsi, Ana Elisa Ribeiro; Liu, Bing; Ji, Weizhi; Wu, Jun; Chen, Yongchang; Tan, Tao | Ex utero monkey embryogenesis from blastocyst to early organogenesis | CELL | 186 | 10 | 2092 | + | 2023 |
| Liu, Yan; Shan, Liang; Liu, Tiane; Li, Juan; Chen, Yongchang; Sun, Changhong; Yang, Chaojuan; Bian, Xiling; Niu, Yuyu; Zhang, Chen; Xi, Jianzhong; Rao, Yi | Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin | NEURON | 111 | 9 | 1468 | + | 2023 |
| Li, Shuang; Chen, Zhenzhen; Chen, Chuanxin; Niu, Yuyu | Multiplexed single-cell transcriptome analysis reveals molecular characteristics of monkey pluripotent stem cell lines | JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 24 | 5 | 418 | 429 | 2023 |
| Liu, Xiaoqian; Liu, Zunpeng; Wu, Zeming; Ren, Jie; Fan, Yanling; Sun, Liang; Cao, Gang; Niu, Yuyu; Zhang, Baohu; Ji, Qianzhao; Jiang, Xiaoyu; Wang, Cui; Wang, Qiaoran; Ji, Zhejun; Li, Lanzhu; Esteban, Concepcion Rodriguez; Yan, Kaowen; Li, Wei; Cai, Yusheng; Wang, Si; Zheng, Aihua; Zhang, Yong E.; Tan, Shengjun; Cai, Yingao; Song, Moshi; Lu, Falong; Tang, Fuchou; Ji, Weizhi; Zhou, Qi; Belmonte, Juan Carlos Izpisua; Zhang, Weiqi; Qu, Jing; Liu, Guang-Hui | Resurrection of endogenous retroviruses during aging reinforces senescence | CELL | 186 | 2 | 287 | + | 2023 |
| Li, Mengjia; Wang, Zhengbo; Zheng, Tianqi; Huang, Tianzhuang; Liu, Baoguo; Han, Deqiang; Liu, Sumei; Liu, Bochao; Li, Mo; Si, Wei; Zhang, Y. Alex; Niu, Yuyu; Chen, Zhiguo | Characterization of Human-Induced Neural Stem Cells and Derivatives following Transplantation into the Central Nervous System of a Nonhuman Primate and Rats | STEM CELLS INTERNATIONAL | 2022 | 2022 | |||
| Lei, Ying; Cheng, Mengnan; Li, Zihao; Zhuang, Zhenkun; Wu, Liang; Sun, Yunong; Han, Lei; Huang, Zhihao; Wang, Yuzhou; Wang, Zifei; Xu, Liqin; Yuan, Yue; Liu, Shang; Pan, Taotao; Xie, Jiarui; Liu, Chuanyu; Volpe, Giacomo; Ward, Carl; Lai, Yiwei; Xu, Jiangshan; Wang, Mingyue; Yu, Hao; Sun, Haixi; Yu, Qichao; Wang, Chunqing; Wong, Chi Wai; Liu, Wei; Xu, Liangzhi; Wei, Jingkuan; Chen, Dandan; Shang, Zhouchun; Li, Guibo; Ma, Kun; Cheng, Le; Ling, Fei; Tan, Tao; Chen, Kai; Tasic, Bosiljka; Dean, Michael; Ji, Weizhi; Yang, Huanming; Gu, Ying; Esteban, Miguel A.; Li, Yuxiang; Chen, Ao; Niu, Yuyu; Zeng, Hongkui; Hou, Yong; Liu, Longqi; Liu, Shiping; Xu, Xun | Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex | NATURE COMMUNICATIONS | 13 | 1 | 2022 | ||
| Bai, Bing; Wang, Yi; Zhu, Ran; Zhang, Yaolei; Wang, Hong; Fan, Guangyi; Liu, Xin; Shi, Hong; Niu, Yuyu; Ji, Weizhi | Long-read sequencing and de novo assembly of the cynomolgus macaque genome | JOURNAL OF GENETICS AND GENOMICS | 49 | 10 | 975 | 978 | 2022 |
| Zheng, Yi; Yan, Robin Zhexuan; Sun, Shiyu; Kobayashi, Mutsumi; Xiang, Lifeng; Yang, Ran; Goedel, Alexander; Kang, Yu; Xue, Xufeng; Esfahani, Sajedeh Nasr; Liu, Yue; Irizarry, Agnes M. Resto; Wu, Weisheng; Li, Yunxiu; Ji, Weizhi; Niu, Yuyu; Chien, Kenneth R.; Li, Tianqing; Shioda, Toshihiro; Fu, Jianping | Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development | CELL STEM CELL | 29 | 9 | 1402 | + | 2022 |
| Jin Xuan; Du Juan; Niu Yuyu; Ji Anjing | Impact of estimated glucose disposal rate for identifying prevalent ischemic heart disease: findings from a cross-sectional study | BMC CARDIOVASCULAR DISORDERS | 22 | 1 | 2022 | ||
| De los Angeles, Alejandro; Regenberg, Alan; Mascetti, Victoria; Benvenisty, Nissim; Church, George; Deng, Hongkui; Belmonte, Juan Carlos Izpisua; Ji, Weizhi; Koplin, Julian; Loh, Yuin-Han; Niu, Yuyu; Pei, Duanqing; Pera, Martin; Pho, Nam; Pinzon-Arteaga, Carlos; Saitou, Mitinori; Silva, Jose C. R.; Tao, Tan; Trounson, Alan; Warrier, Tushar; Zambidis, Elias T. | Why it is important to study human-monkey embryonic chimeras in a dish | NATURE METHODS | 19 | 8 | 914 | 919 | 2022 |
| Kang, Yu; Dai, Shaoxing; Zeng, Yuqiang; Wang, Fang; Yang, Pengpeng; Yang, Zhaohui; Pu, Youwei; Li, Zifan; Chen, Xinglong; Tian, Baohong; Si, Wei; Ji, Weizhi; Niu, Yuyu | Cloning and base editing of GFP transgenic rhesus monkey and off-target analysis | SCIENCE ADVANCES | 8 | 29 | 2022 | ||
| Zhu, Xiaoqing; Guo, Yicheng; Chu, Chu; Liu, Dahai; Duan, Kui; Yin, Yu; Si, Chenyang; Kang, Yu; Yao, Junjun; Du, Xuewei; Li, Junliang; Zhao, Shumei; Ai, Zongyong; Zhu, Qingyuan; Ji, Weizhi; Niu, Yuyu; Li, Tianqing | BRN2 as a key gene drives the early primate telencephalon development | SCIENCE ADVANCES | 8 | 9 | 2022 | ||
| Cheng, Fuwei; Zhao, Shuangping; Li, Jiachen; Niu, Yuyu; Huang, Haiping; Yang, Jicheng; Ma, Shiyin; Liu, Jisheng; Sun, Peng | Enhanced effect of recombinant adenoviruses co-expression of ING4 and OSM on anti-tumour activity of laryngeal cancer | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 26 | 5 | 1556 | 1566 | 2022 |
| Zhong, Tao; Wei, Jingkuan; Wu, Kunhua; Chen, Liangjun; Zhao, Fenqiang; Pei, Yuchen; Wang, Ya; Zhang, Hongjiang; Wu, Zhengwang; Huang, Ying; Li, Tengfei; Wang, Li; Chen, Yongchang; Ji, Weizhi; Zhang, Yu; Li, Gang; Niu, Yuyu | Longitudinal brain atlases of early developing cynomolgus macaques from birth to 48 months of age | NEUROIMAGE | 247 | 2022 | |||
| Chen, Chuanxin; Ji, Weizhi; Niu, Yuyu | Primate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical Research | TRENDS IN BIOTECHNOLOGY | 39 | 12 | 1332 | 1342 | 2021 |
| Chu, Chu; Zhang, Wenhao; Kang, Yu; Si, Chenyang; Ji, Weizhi; Niu, Yuyu; Zhang, Yi | Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta | DEVELOPMENTAL CELL | 56 | 20 | 2826 | + | 2021 |
| Xiao, Puhao; Bai, Raoxian; Zhang, Ting; Wu, Ruo; Chen, Lijiao; Hou, Yu; Shen, Bin; Niu, Yuyu; Li, Shangang; Ji, Weizhi; Chen, Yongchang | Extensive humoral immune response to AAVs and Cas proteins in nonhuman primates | SCIENCE BULLETIN | 66 | 20 | 2061 | 2064 | 2021 |
| Yan, Yaping; Ren, Shuchao; Duan, Yanchao; Lu, Chenyu; Niu, Yuyu; Wang, Zhengbo; Inglis, Briauna; Ji, Weizhi; Zheng, Yun; Si, Wei | Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson's disease | NPJ BIOFILMS AND MICROBIOMES | 7 | 1 | 2021 | ||
| Yang, Ran; Goedel, Alexander; Kang, Yu; Si, Chenyang; Chu, Chu; Zheng, Yi; Chen, Zhenzhen; Gruber, Peter J.; Xiao, Yao; Zhou, Chikai; Witman, Nevin; Leung, Chuen-Yan; Chen, Yongchang; Fu, Jianping; Ji, Weizhi; Lanner, Fredrik; Niu, Yuyu; Chien, Kenneth | Amnion signals are essential for mesoderm formation in primates | NATURE COMMUNICATIONS | 12 | 1 | 2021 | ||
| Chen, Zhen-Zhen; Wang, Jian-Ying; Kang, Yu; Yang, Qiao-Yan; Gu, Xue-Ying; Zhi, Da-Long; Yan, Li; Long, Cheng-Zu; Shen, Bin; Niu, Yu-Yu | PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys | ZOOLOGICAL RESEARCH | 42 | 4 | 469 | + | 2021 |
| Tan, Tao; Wu, Jun; Si, Chenyang; Dai, Shaoxing; Zhang, Youyue; Sun, Nianqin; Zhang, E.; Shao, Honglian; Si, Wei; Yang, Pengpeng; Wang, Hong; Chen, Zhenzhen; Zhu, Ran; Kang, Yu; Hernandez-Benitez, Reyna; Martinez, Llanos Martinez; Delicado, Estrella Nunez; Berggren, W. Travis; Schwarz, May; Ai, Zongyong; Li, Tianqing; Deng, Hongkui; Esteban, Concepcion Rodriguez; Ji, Weizhi; Niu, Yuyu; Belmonte, Juan Carlos Izpisua | Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo (vol 184, pg 2020, 2021) | CELL | 184 | 13 | 3589 | 3589 | 2021 |
| Xu, Hao; Niu, Yuyu; Sun, Yan; Xia, Menglin; Lin, Daozheng; Qiao, Wei | Separation and purification of magnoflorine, spinosin, and 6'-feruloyspinosin from Ziziphi Spinosae Semen by high-speed counter-current chromatography | JOURNAL OF SEPARATION SCIENCE | 44 | 12 | 2391 | 2398 | 2021 |
| Tan, Tao; Wu, Jun; Si, Chenyang; Dai, Shaoxing; Zhang, Youyue; Sun, Nianqin; Zhang, E.; Shao, Honglian; Si, Wei; Yang, Pengpeng; Wang, Hong; Chen, Zhenzhen; Zhu, Ran; Kang, Yu; Hernandez-Benitez, Reyna; Martinez, Llanos Martinez; Delicado, Estrella Nunez; Berggren, W. Travis; Schwarz, May; Ai, Zongyong; Li, Tianqing; Esteban, Concepcion Rodriguez; Ji, Weizhi; Niu, Yuyu; Belmonte, Juan Carlos Izpisua | Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo | CELL | 184 | 8 | 2020 | + | 2021 |
| Zhong, Tao; Zhao, Fenqiang; Pei, Yuchen; Ning, Zhenyuan; Liao, Lufan; Wu, Zhengwang; Niu, Yuyu; Wang, Li; Shen, Dinggang; Zhang, Yu; Li, Gang | DIKA-Nets: Domain-invariant knowledge-guided attention networks for brain skull stripping of early developing macaques | NEUROIMAGE | 227 | 2021 | |||
| Wang, Fang; Zeng, Yuqiang; Wang, Yi; Niu, Yuyu | The Development and Application of a Base Editor in Biomedicine | BIOMED RESEARCH INTERNATIONAL | 2020 | 2020 | |||
| Wang, Fang; Zhang, Weiqi; Yang, Qiaoyan; Kang, Yu; Fan, Yanling; Wei, Jingkuan; Liu, Zunpeng; Dai, Shaoxing; Li, Hao; Li, Zifan; Xu, Lizhu; Chu, Chu; Qu, Jing; Si, Chenyang; Ji, Weizhi; Liu, Guang-Hui; Long, Chengzu; Niu, Yuyu | Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing | PROTEIN & CELL | 11 | 11 | 809 | 824 | 2020 |
| Zhang, Ting; Kang, Yu; Li, Li; Zhou, Yin; Chen, Xinglong; Zhuo, Yan; Li, Zifan; Wang, Hong; Niu, Yuyu; Ji, Weizhi; Li, Shangang; Chen, Yongchang | Interspecies embryo transfer between rhesus and cynomolgus monkeys | JOURNAL OF GENETICS AND GENOMICS | 47 | 6 | 333 | 336 | 2020 |
| Chen, Baohui; Niu, Yuyu; Wang, Haoyi; Wang, Kejian; Yang, Hui; Li, Wei | Recent advances in CRISPR research | PROTEIN & CELL | 11 | 11 | 786 | 791 | 2020 |
| Li, Bin; Niu, Yuyu; Ji, Weizhi; Dong, Yizhou | Strategies for the CRISPR-Based Therapeutics | TRENDS IN PHARMACOLOGICAL SCIENCES | 41 | 1 | 55 | 65 | 2020 |
| Xiang, Lifeng; Yin, Yu; Zheng, Yun; Ma, Yanping; Li, Yonggang; Zhao, Zhigang; Guo, Junqiang; Ai, Zongyong; Niu, Yuyu; Duan, Kui; He, Jingjing; Ren, Shuchao; Wu, Dan; Bai, Yun; Shang, Zhouchun; Dai, Xi; Ji, Weizhi; Li, Tianqing | A developmental landscape of 3D-cultured human pre-gastrulation embryos | NATURE | 577 | 7791 | 537 | + | 2020 |
| Niu, Yuyu; Sun, Nianqin; Li, Chang; Lei, Ying; Huang, Zhihao; Wu, Jun; Si, Chenyang; Dai, Xi; Liu, Chuanyu; Wei, Jingkuan; Liu, Longqi; Feng, Su; Kang, Yu; Si, Wei; Wang, Hong; Zhang, E.; Zhao, Lu; Li, Ziwei; Luo, Xi; Cui, Guizhong; Peng, Guangdun; Belmonte, Juan Carlos Izpisua; Ji, Weizhi; Tan, Tao | Dissecting primate early post-implantation development using long-term in vitro embryo culture | SCIENCE | 366 | 6467 | 837 | + | 2019 |
| Wang, Dan; Niu, Yuyu; Ren, Lingzhi; Kang, Yu; Tai, Phillip W. L.; Si, Chenyang; Mendonca, Craig A.; Ma, Hong; Gao, Guangping; Ji, Weizhi | Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno-Associated Virus | ADVANCED SCIENCE | 6 | 21 | 2019 | ||
| Kang, Yu; Chu, Chu; Wang, Fang; Niu, Yuyu | CRISPR/Cas9-mediated genome editing in nonhuman primates | DISEASE MODELS & MECHANISMS | 12 | 10 | 2019 | ||
| Chen, Zhen-Zhen; Niu, Yu-Yu | Stem cell therapy for Parkinson's disease using non-human primate models | ZOOLOGICAL RESEARCH | 40 | 5 | 349 | 357 | 2019 |
| Zhang, Bo; Zhou, Zhigang; Zhou, Yin; Zhang, Ting; Ma, Yuanye; Niu, Yuyu; Ji, Weizhi; Chen, Yongchang | Social-valence-related increased attention in rett syndrome cynomolgus monkeys: An eye-tracking study | AUTISM RESEARCH | 12 | 11 | 1585 | 1597 | 2019 |
| Niu, Yuyu | Genetic monkeys reveal a new role for a longevity protein in embryonic development | NATIONAL SCIENCE REVIEW | 6 | 3 | 392 | 392 | 2019 |
| Shi, Lei; Luo, Xin; Jiang, Jin; Chen, Yongchang; Liu, Cirong; Hu, Ting; Li, Min; Lin, Qiang; Li, Yanjiao; Huang, Jun; Wang, Hong; Niu, Yuyu; Shi, Yundi; Styner, Martin; Wang, Jianhong; Lu, Yi; Sun, Xuejin; Yu, Hualin; Ji, Weizhi; Su, Bing | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development | NATIONAL SCIENCE REVIEW | 6 | 3 | 480 | 493 | 2019 |
| Wang, Dan; Niu, Yuyu; Ren, Lingzhi; Tai, Phillip W. L.; Ji, Weizhi; Gao, Guangping | Gene Delivery to Non-Human Primate Embryos Using AAV Vectors | MOLECULAR THERAPY | 27 | 4 | 110 | 110 | 2019 |
| Sun, Peng; Zhang, Dan; Huang, Haiping; Yu, Yafeng; Yang, Zhendong; Niu, Yuyu; Liu, Jisheng | MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B | BIOLOGICAL CHEMISTRY | 400 | 2 | 237 | 246 | 2019 |
| Chu, Chu; Yang, Zhaohui; Yang, Jiayin; Yan, Li; Si, Chenyang; Kang, Yu; Chen, Zhenzhen; Chen, Yongchang; Ji, Weizhi; Niu, Yuyu | Homologous recombination-mediated targeted integration in monkey embryos using TALE nucleases | BMC BIOTECHNOLOGY | 19 | 2019 | |||
| Cao Jing; Li Mengjia; Wang Fang; Zeng Yuqiang; Wei Jingkuan; Niu Yuyu | Pluripotent Stem Cells Differentiate into Motor Neurons in Cynomolgus Monkeys | Chinese Journal of Cell Biology | 41 | 10 | 1976 | 1985 | 2019 |
| Kang, Yu; Ai, Zongyong; Duan, Kui; Si, Chenyang; Wang, Yong; Zheng, Yun; He, Jingjing; Yin, Yu; Zhao, Shumei; Niu, Baohua; Zhu, Xiaoqing; Liu, Li; Xiang, Lifeng; Zhang, Linming; Niu, Yuyu; Ji, Weizhi; Li, Tianqing | Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys | CELL REPORTS | 25 | 9 | 2563 | + | 2018 |
| Yan, Li; Jiang, Bin; Niu, Yuyu; Wang, Hongxuan; Li, Enqin; Yan, Yaping; Sun, Huiyan; Duan, Yanchao; Chang, Shaohui; Chen, Guokai; Ji, Weizhi; Xu, Ren-He; Si, Wei | Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model | CELL DEATH DISCOVERY | 4 | 2018 | |||
| Wang, Shuang; Ren, Shuaiwei; Bai, Raoxian; Xiao, Puhao; Zhou, Qin; Zhou, Yin; Zhou, Zhigang; Niu, Yuyu; Ji, Weizhi; Chen, Yongchang | No off-target mutations in functional genome regions of a CRISPR/Cas9-generated monkey model of muscular dystrophy | JOURNAL OF BIOLOGICAL CHEMISTRY | 293 | 30 | 11654 | 11658 | 2018 |
| Cui, Yiqiang; Niu, Yuyu; Zhou, Jiankui; Chen, Yongchang; Cheng, Yiwei; Li, Shangang; Ai, Zongyong; Chu, Chu; Wang, Hong; Zheng, Bo; Chen, Xuejin; Sha, Jiahao; Guo, Xuejiang; Huang, Xingxu; Ji, Weizhi | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination | CELL RESEARCH | 28 | 3 | 383 | 386 | 2018 |
| Chen Zhenzhen; Niu Yuyu | Progress on derivation of human embryonic stem cell | Chinese Bulletin of Life Sciences | 30 | 8 | 906 | 910 | 2018 |
| Wang, Shuang; Yang, Lichuan; Bai, Raoxian; Ren, Shuaiwei; Niu, Yuyu; Ma, Yuanye; Ji, Weizhi; Chen, Yongchang | Interaction of p53 and ASPPs regulates rhesus monkey embryonic stem cells conversion to neural fate concomitant with apoptosis | CELL CYCLE | 17 | 9 | 1146 | 1153 | 2018 |
| Xin, Huijie; Fang, Leilei; Xie, Junbo; Qi, Wuqin; Niu, Yuyu; Yang, Fan; Cai, Dandan; Zhang, Yanqing; Wen, Zhiyou | Identification and Quantification of Triterpenoids in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), with HPLC-MS/MS Methods | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | 20 | 10 | 919 | 934 | 2018 |
| Zhuo, Yan; Feng, Shuqing; Huang, Shaoyong; Chen, Xinglong; Kang, Yu; Si, Chenyang; Li, Zifan; Zhou, Yin; Zhou, Ling; Zhang, Ting; Ji, Weizhi; Niu, Yuyu; Chen, Yongchang | Transabdominal ultrasound-guided multifetal pregnancy reduction in 10 cases of monkeys | BIOLOGY OF REPRODUCTION | 97 | 5 | 758 | 761 | 2017 |
| Niu, Yuyu; Li, Tianqing; Ji, Weizhi | Paving the road for biomedicine: genome editing and stem cells in primates | NATIONAL SCIENCE REVIEW | 4 | 4 | 543 | 549 | 2017 |
| Chen, Yongchang; Yu, Juehua; Niu, Yuyu; Qin, Dongdong; Liu, Hailiang; Li, Gang; Hu, Yingzhou; Wang, Jiaojian; Lu, Yi; Kang, Yu; Jiang, Yong; Wu, Kunhua; Li, Siguang; Wei, Jingkuan; He, Jing; Wang, Junbang; Liu, Xiaojing; Luo, Yuping; Si, Chenyang; Bai, Raoxian; Zhang, Kunshan; Liu, Jie; Huang, Shaoyong; Chen, Zhenzhen; Wang, Shuang; Chen, Xiaoying; Bao, Xinhua; Zhang, Qingping; Li, Fuxing; Geng, Rui; Liang, Aibin; Shen, Dinggang; Jiang, Tianzi; Hu, Xintian; Ma, Yuanye; Ji, Weizhi; Sun, Yi Eve | Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys | CELL | 169 | 5 | 945 | + | 2017 |
| Wang, Dan; Yoon, Yeonsoo; Niu, Yuyu; Tai, Phillip W. L.; Riley, Joy; Ji, Weizhi; Rivera-Perez, Jaime A.; Gao, Guangping | Easy and Efficient Gene Editing of Mammalian Embryos Using rAAV Vectors - From Mouse to Monkey | MOLECULAR THERAPY | 25 | 5 | 11 | 11 | 2017 |
| Gao, Fei; Niu, Yuyu; Sun, Yi Eve; Lu, Hanlin; Chen, Yongchang; Li, Siguang; Kang, Yu; Luo, Yuping; Si, Chenyang; Yu, Juehua; Li, Chang; Sun, Nianqin; Si, Wei; Wang, Hong; Ji, Weizhi; Tan, Tao | De novo DNA methylation during monkey pre-implantation embryogenesis | CELL RESEARCH | 27 | 4 | 526 | 539 | 2017 |
| Fu, Xufeng; Yan, Yaping; Li, Shanshan; Wang, Junfeng; Jiang, Bin; Wang, Hong; Duan, Yanchao; Tan, Tao; Gao, Fei; Gong, Desheng; Niu, Yuyu; Ji, Weizhi; Zheng, Bingrong; Si, Wei | Vitrification of Rhesus Macaque Mesenchymal Stem Cells and the Effects on Global Gene Expression | STEM CELLS INTERNATIONAL | 2017 | 2017 | |||
| Yan, Yaping; Ao, Lei; Wang, Hong; Duan, Yanchao; Chang, Shaohui; Chen, Bingbing; Zhi, Dalong; Li, Sujuan; Niu, Yuyu; Ji, Weizhi; Si, Wei | Cryopreservation of Cynomolgus Macaque (Macaca fascicularis) Sperm by Using a Commercial Egg-Yolk-Free Freezing Medium | JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE | 55 | 6 | 744 | 748 | 2016 |
| Zhu, Xiaoqing; Li, Bo; Ai, Zongyong; Xiang, Zheng; Zhang, Kunshang; Qiu, Xiaoyan; Chen, Yongchang; Li, Yuemin; Rizak, Joshua D.; Niu, Yuyu; Hu, Xintian; Sun, Yi Eve; Ji, Weizhi; Li, Tianqing | A Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease Studies | STEM CELL REPORTS | 6 | 2 | 228 | 242 | 2016 |
| Kang, Yu; Zheng, Bo; Shen, Bin; Chen, Yongchang; Wang, Lei; Wang, Jianying; Niu, Yuyu; Cui, Yiqiang; Zhou, Jiankui; Wang, Hong; Guo, Xuejiang; Hu, Bian; Zhou, Qi; Sha, Jiahao; Ji, Weizhi; Huang, Xingxu | CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH | HUMAN MOLECULAR GENETICS | 24 | 25 | 7255 | 7264 | 2015 |
| Zhi Dalong; Niu Yuyu; Ji Weizhi | Genome Editing Technologies Based on Engineered Nuclease | Chinese Journal of Biochemistry and Molecular Biology | 31 | 11 | 1132 | 1137 | 2015 |
| Wang, Hong; Tan, Tao; Wang, Junfeng; Niu, Yuyu; Yan, Yaping; Guo, Xiangyu; Kang, Yu; Duan, Yanchao; Chang, Shaohui; Liao, Jianpeng; Si, Chenyang; Ji, Weizhi; Si, Wei | Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis | SCIENTIFIC REPORTS | 5 | 2015 | |||
| Chen, Yongchang; Niu, Yuyu; Li, Yanjiao; Ai, Zongyong; Kang, Yu; Shi, Hong; Xiang, Zheng; Yang, Zhaohui; Tan, Tao; Si, Wei; Li, Wei; Xia, Xueshan; Zhou, Qi; Ji, Weizhi; Li, Tianqing | Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells | CELL STEM CELL | 17 | 1 | 116 | 124 | 2015 |
| Chen, Yongchang; Zheng, Yinghui; Kang, Yu; Yang, Weili; Niu, Yuyu; Guo, Xiangyu; Tu, Zhuchi; Si, Chenyang; Wang, Hong; Xing, Ruxiao; Pu, Xiuqiong; Yang, Shang-Hsun; Li, Shihua; Ji, Weizhi; Li, Xiao-Jiang | Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9 | HUMAN MOLECULAR GENETICS | 24 | 13 | 3764 | 3774 | 2015 |
| Niu, Yuyu; Guo, Xiangyu; Chen, Yongchang; Wang, Chuan-En; Gao, Jinquan; Yang, Weili; Kang, Yu; Si, Wei; Wang, Hong; Yang, Shang-Hsun; Li, Shihua; Ji, Weizhi; Li, Xiao-Jiang | Early Parkinson's disease symptoms in α-synuclein transgenic monkeys | HUMAN MOLECULAR GENETICS | 24 | 8 | 2308 | 2317 | 2015 |
| Chen, Yongchang; Cui, Yiqiang; Shen, Bin; Niu, Yuyu; Zhao, Xiaoyang; Wang, Lei; Wang, Jianying; Li, Wei; Zhou, Qi; Ji, Weizhi; Sha, Jiahao; Huang, Xingxu | Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys | CELL RESEARCH | 25 | 2 | 262 | 265 | 2015 |
| Wan, Haifeng; Feng, Chunjing; Teng, Fei; Yang, Shihua; Hu, Baoyang; Niu, Yuyu; Xiang, Andy Peng; Fang, Weizhen; Ji, Weizhi; Li, Wei; Zhao, Xiaoyang; Zhou, Qi | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system | CELL RESEARCH | 25 | 2 | 258 | 261 | 2015 |
| Kang Yu; Chen Yongchang; Niu Yuyu | Research progress of genome editing in nonhuman primates | Chinese Bulletin of Life Sciences | 27 | 1 | 50 | 55 | 2015 |
| Tan, Tao; Lu, Bin; Zhang, Jing; Niu, Yuyu; Si, Wei; Wei, Qiang; Ji, Weizhi | Notch1 Signaling Antagonizes Transforming Growth Factor- b Pathway and Induces Apoptosis in Rabbit Trophoblast Stem Cells | STEM CELLS AND DEVELOPMENT | 23 | 8 | 813 | 822 | 2014 |
| Liu, Hailiang; Chen, Yongchang; Niu, Yuyu; Zhang, Kunshan; Kang, Yu; Ge, Weihong; Liu, Xiaojing; Zhao, Enfeng; Wang, Chencheng; Lin, Shaoyun; Jing, Bo; Si, Chenyang; Lin, Quan; Chen, Xiaoying; Lin, Haijun; Pu, Xiuqiong; Wang, Yingying; Qin, Binlian; Wang, Fang; Wang, Hong; Si, Wei; Zhou, Jing; Tan, Tao; Li, Tianqing; Ji, Shaohui; Xue, Zhigang; Luo, Yuping; Cheng, Liming; Zhou, Qi; Li, Siguang; Sun, Yi Eve; Ji, Weizhi | TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys | CELL STEM CELL | 14 | 3 | 323 | 328 | 2014 |
| Niu, Yuyu; Shen, Bin; Cui, Yiqiang; Chen, Yongchang; Wang, Jianying; Wang, Lei; Kang, Yu; Zhao, Xiaoyang; Si, Wei; Li, Wei; Xiang, Andy Peng; Zhou, Jiankui; Guo, Xuejiang; Bi, Ye; Si, Chenyang; Hu, Bian; Dong, Guoying; Wang, Hong; Zhou, Zuomin; Li, Tianqing; Tan, Tao; Pu, Xiuqiong; Wang, Fang; Ji, Shaohui; Zhou, Qi; Huang, Xingxu; Ji, Weizhi; Sha, Jiahao | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos | CELL | 156 | 4 | 836 | 843 | 2014 |
| Luo, Huanhua; Niu, Yuyu; Duan, Changqing; Su, Haijia; Yan, Guoliang | A pH control strategy for increased β-carotene production during batch fermentation by recombinant industrial wine yeast | PROCESS BIOCHEMISTRY | 48 | 2 | 195 | 200 | 2013 |
| Chen, Yongchang; Wang, Zhengbo; Xie, Yunhua; Guo, Xiangyu; Tang, Xianghui; Wang, Shufen; Yang, Shihua; Chen, Kai; Niu, Yuyu; Ji, Weizhi | Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells | JOURNAL OF NEUROSCIENCE RESEARCH | 90 | 7 | 1382 | 1391 | 2012 |
| Chen, Yongchang; Niu, Yuyu; Ji, Weizhi | Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors | JOURNAL OF GENETICS AND GENOMICS | 39 | 6 | 247 | 251 | 2012 |
| Chen, Yongchang; Niu, Yuyu; Yang, Shihua; He, Xiechao; Ji, Shaohui; Si, Wei; Tang, Xianghui; Xie, Yunhua; Wang, Hong; Lu, Yongqing; Zhou, Qi; Ji, Weizhi | The Available Time Window for Embryo Transfer in the Rhesus Monkey (Macaca mulatta) | AMERICAN JOURNAL OF PRIMATOLOGY | 74 | 2 | 165 | 173 | 2012 |
| Wang, Hong; Si, Wei; Niu, Yuyu; Chen, Lixian; Yan, Ye | Unusual Vesical Calculus in Rhesus Monkey (Macaca mulatta) | JOURNAL OF ANIMAL AND VETERINARY ADVANCES | 11 | 11 | 1790 | 1792 | 2012 |
| Yang, Shihua; Ping, Shuhuang; Ji, Shaohui; Lu, Yongqing; Niu, Yuyu; Wang, Hong; Ji, Weizhi; Si, Wei | The Positive Effects of Seminal Plasma During the Freezing Process on Cryosurvival of Sperm with Poor Freezability in the Rhesus Macaque (Macaca mulatta) | JOURNAL OF REPRODUCTION AND DEVELOPMENT | 57 | 6 | 737 | 743 | 2011 |
| Fu Xianghua; Niu Yuyu; Fan Weise; Wang Yanbo; Wang Xuechao; Gu Xinshun; Jiang Yunfa | THE COMPARISON OF EARLY AND ELECTIVE PCI AFTER THROMBOLYSIS REPATENCY WITH RETEPLASE IN STEMI PATIENTS | HEART | 97 | 2011 | |||
| Yang, Shihua; Ping, Shuhuang; Si, Wei; He, Xiechao; Wang, Xinyi; Lu, Yongqing; Ji, Shaohui; Niu, Yuyu; Ji, Weizhi | Optimization of Ethylene Glycol Concentrations, Freezing Rates and Holding Times in Liquid Nitrogen Vapor for Cryopreservation of Rhesus Macaque (Macaca mulatta) Sperm | JOURNAL OF VETERINARY MEDICAL SCIENCE | 73 | 6 | 717 | 723 | 2011 |
| Tan, Tao; Tang, Xianghui; Zhang, Jing; Niu, Yuyu; Chen, Hongwei; Li, Bin; Wei, Qiang; Ji, Weizhi | Generation of Trophoblast Stem Cells from Rabbit Embryonic Stem Cells with BMP4 | PLOS ONE | 6 | 2 | 2011 | ||
| Chen, Yongchang; Niu, Yuyu; Ji, Shaohui; He, Xiechao; Tang, Xianghui; Xie, Yunhua; Ji, Weizhi | Initiation Timing Cannot Predict Success of Superovulation in Rhesus Monkeys (Macaca mulatta) | JOURNAL OF ANIMAL AND VETERINARY ADVANCES | 10 | 24 | 3293 | 3296 | 2011 |
| Chen, Yongchang; Ji, Shaohui; Niu, Yuyu; He, Xiechao; Xie, Yunhua; Tang, Xianghui; Ji, Weizhi | Recombinant Human Gonadotropins for Rhesus Monkey Superovulation: Age and the Stimulation Interval are Determinant to the Fecundity | JOURNAL OF ANIMAL AND VETERINARY ADVANCES | 10 | 24 | 3303 | 3307 | 2011 |
| Si, Wei; Lu, Yongqing; He, Xiechao; Ji, Shaohui; Niu, Yuyu; Tan, Tao; Ji, Weizhi | Directional freezing as an alternative method for cryopreserving rhesus macaque (Macaca mulatta) sperm | THERIOGENOLOGY | 74 | 8 | 1431 | 1438 | 2010 |
| Niu, Yuyu; Yu, Yang; Bernat, Agnieszka; Yang, Shihua; He, Xiechao; Guo, Xiangyu; Chen, Dongliang; Chen, Yongchang; Ji, Shaohui; Si, Wei; Lv, Yongqin; Tan, Tao; Wei, Qiang; Wang, Hong; Shi, Lei; Guan, Jean; Zhu, Xuemei; Afanassieff, Marielle; Savatier, Pierre; Zhang, Kang; Zhou, Qi; Ji, Weizhi | Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 107 | 41 | 17663 | 17667 | 2010 |
| Wang, Yingying; Hai, Tang; Liu, Zichuan; Zhou, Shuya; Lv, Zhuo; Ding, Chenhui; Liu, Lei; Niu, Yuyu; Zhao, Xiaoyang; Tong, Man; Wang, Liu; Jouneau, Alice; Zhang, Xun; Ji, Weizhi; Zhou, Qi | HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 397 | 3 | 407 | 412 | 2010 |
| Wang, Shufen; Shen, Yi; Yuan, Xiaohua; Chen, Kai; Guo, Xiangyu; Chen, Yongchang; Niu, Yuyu; Li, Jian; Xu, Ren-He; Yan, Xiyun; Zhou, Qi; Ji, Weizhi | Dissecting Signaling Pathways That Govern Self-renewal of Rabbit Embryonic Stem Cells | JOURNAL OF BIOLOGICAL CHEMISTRY | 283 | 51 | 35929 | 35940 | 2008 |
| Niu, Yuyu; Yang, Shihua; Yu, Yang; Ding, Chenhui; Yang, Jifeng; Wang, Shufen; Ji, Shaohui; He, Xiechao; Xie, Yunhua; Tang, Xianghui; Zhou, Qi; Ji, Weizhi | Impairments in embryonic genome activation in rhesus monkey somatic cell nuclear transfer embryos | CLONING AND STEM CELLS | 10 | 1 | 25 | 35 | 2008 |
| Wang, Shufen; Tang, Xianghui; Niu, Yuyu; Chen, Hongwei; Li, Bin; Li, Tianqing; Zhang, Xiuzhen; Hu, Zhixin; Zhou, Qi; Ji, Weizhi | Generation and characterization of rabbit embryonic stem cells | STEM CELLS | 25 | 2 | 481 | 489 | 2007 |
| Niu, Yuyu; Yang, Shihua; Yang, Jifeng; He, Xiechao; Tang, Xianghui; Xie, Yunhua; Zhou, Qi; Ji, Weizhi | Mamu-AG transcription in preimplantation embryos derived from SCNT and IVF in rhesus monkey. | BIOLOGY OF REPRODUCTION | 164 | 165 | 2007 | ||
| Yang, Jifeng; Yang, Shihua; Beaujean, Nathalie; Niu, Yuyu; He, Xiechao; Xie, Yunhua; Tang, Xianghui; Wang, Liu; Zhou, Qi; Ji, Weizhi | Epigenetic marks in cloned rhesus monkey embryos: Comparison with counterparts produced in vitro | BIOLOGY OF REPRODUCTION | 76 | 1 | 36 | 42 | 2007 |
| Niu, Yuyu; Greube, Alexa; Ji, Weizhi; Jewgenow, Katarina | The application of in vitro sperm competition test to evaluate the impact of ZP-derived peptides on fertilization capacity of cat sperm | THERIOGENOLOGY | 66 | 4 | 989 | 995 | 2006 |
扩展阅读：
https://rsc.kmust.edu.cn/info/1181/1395.htm
牛昱宇
https://blog.sciencenet.cn/blog-454141-1411417.html
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