2023年8月24日，ACS旗下国际著名top期刊《Analytical Chemistry》在线发表了云南师范大学化学化工学院袁黎明教授团队谢生明教授的最新研究成果《Homochiral Metallacycle Used as a Stationary Phase for Capillary Gas Chromatographic Separation of Chiral and Achiral Compounds》。云南师范大学化学化工学院为唯一作者和通讯作者单位。通讯作者为章俊辉副教授和谢生明教授。

Abstract

Metallacycles are a novel class of supramolecular materials with circular structures, internal cavities, and abundant host–guest chemical properties that have exhibited good application prospects in many fields. However, to the best of our knowledge, no research on the use of metallacycles as stationary phases for gas chromatographic (GC) separations has been published yet. In this work, we report for the first time the use of a homochiral metallacycle, [ZnCl2L]2, as a stationary phase for GC separations. [ZnCl2L]2 was synthesized by reaction of (S)-(1-isonicotinoylpyrrolidin-2-yl)methyl-isonicotinate (L) with ZnCl2 via coordination-driven self-assembly. The [ZnCl2L]2-coated column displayed an excellent separation performance not only of organic isomers but also of racemic compounds. Sixteen racemates (including alcohols, esters, amino acid derivatives, ethers, organic acids, and epoxides) and 21 isomeric compounds (including positional, structural, and cis/trans-isomers) were well separated on the [ZnCl2L]2-coated column. Impressively, some racemates were resolved with high resolution values (Rs), including 1,2-butanediol diacetate (Rs = 25.86), ethyl 3-hydroxybutyrate (Rs = 20.97), 1,3-butanediol diacetate (Rs = 18.09), and threonine derivative (Rs = 18.61). Compared with the commercial β-DEX 120 column for separation of the tested racemates, the [ZnCl2L]2-coated column exhibited good enantioseparation complementarity, enabling separation of some racemates that could not be separated, or were not well resolved, by the β-DEX 120 column. In addition, many organic mixtures, such as n-alkanes, alkylbenzenes, n-alcohols, and a Grob test mixture, were also well separated on the [ZnCl2L]2-coated column. The column also has good reproducibility and thermal stability on separation. This work not only reveals the great potential of metallacycles for GC separations but also opens up a new application of metallacycles in separation science.

全文链接：

https://doi.org/10.1021/acs.analchem.3c02438

https://pubs.acs.org/doi/10.1021/acs.analchem.3c02438

《Analytical Chemistry》隶属于美国化学学会（American Chemical Society），周刊。1947年创刊，ISSN为0003-2700。致力于传播分析化学所有分支领域的新知识和原创知识。基础文章可以讨论化学测量科学的一般原理（重要化学参数相关）。文章可以是理论性的，也可以是实验结果报告。

云师大化工学院袁黎明教授课题组在《J. Am. Chem. Soc.》（美国化学会志）刊登最新研究成果

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