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当然这是细胞学研究,细胞培养环境和机体的情况完全不同,这一推测需要动物实验来证明。作者认为氢气清除活性氧和抗肿瘤有关系的推测并不可靠,抗氧化不等于抗肿瘤效应,而且这种效应对放疗等治疗方法有可能具有对抗效应,也就是说帮助肿瘤细胞逃避药物和射线杀伤的作用。因此需要全面分析这个问题,不过这一研究也给氢气的细胞学研究提供了一种给气体的手段。但使用过程必须考虑金属镁腐蚀过程中对培养液中镁离子浓度的影响。
Reactive oxygen plays an important role in the pathogenesis of many serious illnesses, including bony cancer. Recently, it has been suggested that hydrogen (H2), a selective antioxidant, can effectively scavenge free radicals. Biomedical magnesium (Mg) used for bone defect repair in the surgery of bony cancer could release H2 because of the degradation, so Mg might have the potential to prevent bony cancer from metastasis and recurrence. In this study, alkali-heat treatment method was employed to modify the surface structure of Mg metal, so as to control the degradation of Mg metal and the H2 releasing rate. Then the released H2 was introduced to the Fenton Reaction system to detect its effect on scavenging free radicals. The modified Mg metal was employed as the substrate for bone cancer cell culture to study the effect of the H2 releasing on scavenging free radicals in the cells. It is found that the H2 released from the Mg degradation could scavenge free radicals both in the Fenton Reaction system and bone cancer cells. The effect on the scavenging free radical is proportional to the rate of H2 releasing. It suggested that Mg might be a potential material with anti-bone cancer properties. It is hopeful to both repair the bone defect and prevent bony cancer from metastasis and recurrence for the bony cancer patients by biomedical Mg metal.
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