中尾博士现任日本兵库医科大学急救医学和小儿外科学副教授，曾任美国匹兹堡大学心脏血管外科副教授，国际外科学会会员，《医学气体研究》副主编。2011年中尾博士曾组织一个医疗队，从美国飞往日本，赶赴海啸灾区一线开展医疗服务。他长期从事一氧化碳和氢气对器官损伤保护的研究，尤其是在器官移植损伤方面有比较深入的研究。

中尾博士是美国最早开展氢气生物医学研究的学者，2008年他发表的呼吸氢气降低小肠移植损伤的文章已经成为这个领域的经典文献之一。在国际上他的小组率先证明氢气具有抗炎作用，并全面探讨了氢气呼吸对小肠和心脏器官移植后损伤、机械通气和高分压氧气引起肺损伤保护的研究。采用饮用氢气水，证明氢气水对肾脏器官移植后肾病、对抗氧化衰老的效应。他积极开展氢气的临床效应研究，曾最早证明氢气水可提高恶性肿瘤放射治疗后生活质量下降和治疗代谢综合征等作用。在氢气作用机制方面，他不仅证明氢气的抗炎症作用，而且提出氢气可诱导内源性抗氧化作用，该作用是依赖于Nrf2通路介导的多种抗氧化酶基因表达上调。他在美国积极推广氢气水提高人体健康的概念，受到美国国家航空航天局的关注，并和该机构合作开展氢气对太空辐射损伤的探索性研究。

相关论文

1.       Kawamura T, Wakabayashi N, Shigemura N, Huang CS, MasutaniK, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y,Kensler TW, Nakao A. Hydrogen gas reduces hyperoxic lung injury via the Nrf2pathway in vivo. Am J Physiol Lung Cell Mol Physiol. 2013 May15;304(10):L646-56.

2.       Noda K, Shigemura N, Tanaka Y, Kawamura T, Hyun Lim S,Kokubo K, Billiar TR, Bermudez CA, Kobayashi H, Nakao A. A novel method ofpreserving cardiac grafts using a hydrogen-rich water bath. J Heart LungTransplant. 2013 Feb;32(2):241-50. doi: 10.1016/j.healun.2012.11.004. Epub 2012Dec 28.

3.       Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Kaneko K,Nakao A, Imaoka T. A basic study on molecular hydrogen (H2) inhalation in acutecerebral ischemia patients for safety check with physiological parameters andmeasurement of blood H2 level. Med Gas Res. 2012 Aug 23;2(1):21.

4.       Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB,Billiar TR, Toyoda Y, Bermudez CA, Lyons-Weiler J, Nakao A. Profiling molecularchanges induced by hydrogen treatment of lung allografts prior to procurement.Biochem Biophys Res Commun. 2012 Sep 7;425(4):873-9. doi:10.1016/j.bbrc.2012.08.005. Epub 2012 Aug 7.

5.       Noda K, Tanaka Y, Shigemura N, Kawamura T, Wang Y, MasutaniK, Sun X, Toyoda Y, Bermudez CA, Nakao A. Hydrogen-supplemented drinking waterprotects cardiac allografts from inflammation-associated deterioration. TransplInt. 2012 Dec;25(12):1213-22

6.       Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, NakazawaJ, Kaneko K, Nakao A. Hydrogen(H2) treatment for acute erythymatous skindiseases. A report of 4 patients with safety data and a non-controlledfeasibility study with H2 concentration measurement on two volunteers. Med GasRes. 2012 May 20;2(1):14. doi: 10.1186/2045-9912-2-14.

7.       Aoki K, Nakao A, Adachi T, Matsui Y, Miyakawa S. Pilotstudy: Effects of drinking hydrogen-rich water on muscle fatigue caused byacute exercise in elite athletes. Med Gas Res. 2012 Apr 20;2(1):12.

8.       Sun Q, Kawamura T, Masutani K, Peng X, Sun Q, Stolz DB,Pribis JP, Billiar TR, Sun X, Bermudez CA, Toyoda Y, Nakao A. Oral intake ofhydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts inrats. Cardiovasc Res. 2012 Apr 1;94(1):144-53.

9.       Ohta S, Nakao A, Ohno K. The 2011 Medical Molecular HydrogenSymposium: An inaugural symposium of the journal Medical Gas Research. Med GasRes. 2011 Jun 7;1(1):10. doi: 10.1186/2045-9912-1-10.

10.     Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T, Toyoda Y, NakaoA. Effects of drinking hydrogen-rich water on the quality of life of patientstreated with radiotherapy for liver tumors. Med Gas Res. 2011 Jun 7;1(1):11.doi: 10.1186/2045-9912-1-11.

11.     Buchholz BM, Masutani K, Kawamura T, Peng X, Toyoda Y,Billiar TR, Bauer AJ, Nakao A. Hydrogen-enriched preservation protects theisogeneic intestinal graft and amends recipient gastric function duringtransplantation. Transplantation. 2011 Nov 15;92(9):985-92. doi:10.1097/TP.0b013e318230159d.

12.     Kawamura T, Huang CS, Peng X, Masutani K, Shigemura N,Billiar TR, Okumura M, Toyoda Y, Nakao A. The effect of donor treatment withhydrogen on lung allograft function in rats. Surgery. 2011 Aug;150(2):240-9

13.     Huang CS, Kawamura T, Peng X, Tochigi N, Shigemura N,Billiar TR, Nakao A, Toyoda Y. Hydrogen inhalation reduced epithelial apoptosisin ventilator-induced lung injury via a mechanism involving nuclearfactor-kappa B activation. Biochem Biophys Res Commun. 2011 May 6;408(2):253-8.

14.     Huang CS, Kawamura T, Lee S, Tochigi N, Shigemura N,Buchholz BM, Kloke JD, Billiar TR, Toyoda Y, Nakao A. Hydrogen inhalationameliorates ventilator-induced lung injury. Crit Care. 2010;14(6):R234.

15.     Kawamura T, Huang CS, Tochigi N, Lee S, Shigemura N, BilliarTR, Okumura M, Nakao A, Toyoda Y. Inhaled hydrogen gas therapy for preventionof lung transplant-induced ischemia/reperfusion injury in rats.Transplantation. 2010 Dec 27;90(12):1344-51

16.     Schoenfeld MP, Ansari RR, Zakrajsek JF, Billiar TR, ToyodaY, Wink DA, Nakao A. Hydrogen therapy may reduce the risks related toradiation-induced oxidative stress in space flight. Med Hypotheses. 2011Jan;76(1):117-8.

17.     Huang CS, Kawamura T, Toyoda Y, Nakao A. Recent advances inhydrogen research as a therapeutic medical gas. Free Radic Res. 2010Sep;44(9):971-82.

18.     Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, ZhouWP, Shen RX, Yang JM, Sun XJ. Hydrogen-rich saline protects against liverinjury in rats with obstructive jaundice. Liver Int. 2010 Aug;30(7):958-68

19.     Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM,Nakao A. Drinking hydrogen water ameliorated cognitive impairment insenescence-accelerated mice. J Clin Biochem Nutr. 2010 May;46(3):269-76.

20.     Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N.Effectiveness of hydrogen rich water on antioxidant status of subjects withpotential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr.2010 Mar;46(2):140-9

21.     Nakao A, Kaczorowski DJ, Wang Y, Cardinal JS, Buchholz BM,Sugimoto R, Tobita K, Lee S, Toyoda Y, Billiar TR, McCurry KR. Amelioration ofrat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbonmonoxide, or both. J Heart Lung Transplant. 2010 May;29(5):544-53.

22.     Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurryKR, Billiar TR, Nakao A. Oral hydrogen water prevents chronic allograftnephropathy in rats. Kidney Int. 2010 Jan;77(2):101-9.

23.     Nakao A, Sugimoto R, Billiar TR, McCurry KR. Therapeuticantioxidant medical gas. J Clin Biochem Nutr. 2009 Jan;44(1):1-13.

24.     Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y,Billiar TR, McCurry KR, Bauer AJ, Nakao A. Hydrogen inhalation amelioratesoxidative stress in transplantation induced intestinal graft injury. Am JTransplant. 2008 Oct;8(10):2015-24.

Atsunori NakaoMD 
University of PittsburghSchool of Medicine
Pittsburgh, PA, USA

Project: The evaluation ofcarbon monoxide inhalation for the prevention of ischemia/reperfusion injuryassociated with organ transplantation

现在中尾教授已经回到日本，任职于日本兵库医科大学院

Hyogo MedicalSchool, Japan

中尾教授是日本抗震救灾英雄，那2011年大地震海啸后，他立刻从美国飞回日本，经历各种困难，最后进入灾区，利用个人的医术给灾区的民众解决医疗卫生问题，在后期担任美国救援部队的翻译工作。以下是关于他这段经历的一个英文介绍。他在救灾中表现出的爱国精神值得学习，是一位令人尊重的日本学者。

http://pittsburgh.cbslocal.com/2011/03/30/surgeon-recounts-devastation-in-japan/

PITTSBURGH (KDKA) — A Japanese surgeon, whoworks in Pittsburgh as a transplant researcher, was called on as part of aJapanese medical disaster team.

The team of two doctors, two nurses and apharmacist took care of people in need in the area hit hardest.

Dr. Atsunori Nakao didn’t know what to expectwhen he arrived in his home country to help after the earthquake and tsunami.

After a 12-hour flight from Detroit toTokyo, he couldn’t get to the countryside where people needed help. The trainsweren’t running.

A friend picked him up, but had to wait fivehours for a tank of gas.

They drove nearly 200 miles in the snow toa school that had become a shelter for 1,500 people, huddled in blankets.

“As far as I know, more than 200,000 inshelters without heat, without power,” says Dr. Nakao.

There was no running water and no food. “Justgiving us the one rice bowl in the morning, one rice bowl in the evening. Nomeat. No fish at all,” he said.

There were many older people. Some had highblood pressure, diabetes and infections because of the unsanitary conditions.

He had no medicine – only a bag ofHershey’s chocolates. Despite the hopelessness, they peacefully stood in line.

“They were always thinking about olderpeople and kids. That was amazing. There was not any violence. I didn’t seeanyone shouting or angry or nothing,” he described.

Medicine arrived the next day, but all themedicine in the world couldn’t fix the anguish.

“People sort of lost everythingimmediately,” Dr. Nakao said. “Families, kids, everything.”

When the American Army came, he served as atranslator. “They brought food, or toys, or water. They helped a lot.”

Dr. Nakao was there for a week and even gotsick himself. When it was time to go, he wished he could have done more. “Myheart is very…that’s painful. That’s all.”

Heexpects conditions have improved, but believes help is still needed. Thedonations can be applied to food, medicine, shelter, or whatever need isgreatest at the time.