氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

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静脉射氢气注射液治疗脑缺血患者的安全性

已有 4890 次阅读 2013-6-26 21:39 |个人分类:氢气生理盐水|系统分类:论文交流| 安全性, 注射液

氢气的重要生物学效应是用脑缺血动物模型确定的,但目前除有少数脑干缺血的临床报道外,并没有数量较的临床研究。

最近来自日本国防医科大学神经外科的学者的一篇关于氢气治疗中风的临床研究报道,在线发表在《医学气体研究》上,研究由三家医院共同完成,共有38名临床不同程度的脑缺血患者,每天注射氢气饱和的葡萄糖溶液200毫升,同时联合使用衣达拉丰,部分患者进行了(t-PA)溶栓治疗,在治疗3天、7天和90天后分别观察了血液生化、尿液、脑点图、胸部x线片,并观察了血液MDA含量,38例患者中有1例因心衰死亡,1例出现腹泻,其余没有观察到异常。研究结果提示,静脉注射氢气溶液对中风,包括经溶栓治疗的患者是安全的。遗憾地是,由于研究缺乏对照组,因此无法确定这种治疗是否有临床意义。

免费全文:The complete article is availableas a provisional PDF.The fully formatted PDFand HTML versions are in production.

Safety of intravenous administration of hydrogen-enrichedfluid in patients with acute cerebral ischemia: initial clinical studies

Kimihiro Nagatani, Hiroshi Nawashiro, Satoru Takeuchi, Satoshi Tomura,Naoki Otani, Hideo Osada, Kojiro Wada, Hiroshi Katoh,Nobusuke Tsuzuki and Kentaro Mori  

Background

Most of the results regarding hydrogen (H2) therapy foracute cerebral ischemia are derived from in vitro studies and animalexperiments, with only a few obtained from human trials with a limited numberof subjects. Thus, there is a paucity of information regarding both thebeneficial therapeutic effects as well as the side effects of H2 on acutecerebral ischemia in humans. We designed a pilot study to investigate singledose intravenous H2-administration in combination with edaravone, aiming toprovide an initial estimate of the possible risks and benefits in selectpatients presenting with acute ischemic stroke.

MethodsAn open-label, prospective, non-randomized study of intravenousH2-administration was performed in 38 patients hospitalized for acute ischemicstroke. All patients received an H2-enriched intravenous solution in additionto edaravone immediately after the diagnosis of acute ischemic stroke. Acutestroke patients within 3 h of onset received intravenous tissue plasminogenactivator (t-PA) (0.6 mg/kg) treatment, and patients receiving t-PA had tocommence the administration of the H2-enriched intravenous solution andedaravone before or at the same time as the t-PA was infused.

Results Complications wereobserved in 2 patients (5.3%), which consisted of diarrhea in 1 patient (2.6%)and cardiac failure in 1 patient (2.6%). No deterioration in laboratory tests,urinary tests, ECG, or chest X-ray radiograms occurred in any patient in thisstudy. In all patients, the mean National Institutes of Health Stroke Scale(NIHSS) scores at baseline, and 7, 30, and 90 d after admission were 8.2 +/-7.5, 5.6 +/- 7.1, 4.9 +/- 6.5, and 4.5 +/- 6.3, respectively. The earlyrecanalization was identified in 4 of 11 patients (36.4%) who receivedintravenous t-PA administration. Hemorrhagic transformation was observed in 2patients (18.2%). None of the patients in this study that were treated witht-PA developed symptomatic intracranial hemorrhage.

Conclusions Data from thecurrent study indicate that an H2-enriched intravenous solution is safe forpatients with acute cerebral infarction, including patients treated with t-PA.




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2015-3-18 22:091 婵犲痉鏉库偓妤呭Υ鐎n剚顫曟繛鍡樻尭閻愬﹪鏌i幇顒佲枙婵¤尙绮穱濠囧Χ婢跺绱甸柣搴ㄦ涧閻倿寮澶嬫櫢闁跨噦鎷� 闂佽崵濮嶅鍡楊伓 闂佽崵濮嶅鍡楊伓 +1 |
IP: 210.72.128.*   | 闂佽崵濮嶅鍡楊伓 闂佽崵濮嶅鍡楊伓 +1 [2]闁诲孩顔栭崰姘叏鐎靛憡宕查柛宀€鍋涘Λ姗€鏌ㄩ悤鍌涘   2015-3-18 18:26
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闂備焦鎮堕崕鎶藉磻濞戔懞鍥晸閿燂拷  闂備焦瀵ч崘濠氬箯閿燂拷 濠电儑绲藉ú銈夊箹椤愶富鏁嬫い鏃傗拡濞存牠鏌涢幇闈涘箹鐏忓繘鏌℃径鍡樻珕闁告梹鐗曢敃銏ゎ敂閸繂鐝樻繝銏f硾閿曘倛銇愬ú顏呭仱闁硅櫣鍋熺粊鐑芥煃瑜滈崜銊╁箯閿燂拷
闂佽閰eḿ褍锕㈡潏鈺佸灊闁挎稑瀚€氬鏌i悢鍝勵暭閻庢氨婢慍I闂備礁鎼悧鍡浰囬幍顔剧焾闁秆勵殔閸屻劍鎱ㄥΟ鍧楀摵闁伙綁浜堕弻娑滅疀閺囥劍顥撻梺鍛婄懐閸o絾淇婇幘顔芥櫢闁跨噦鎷�
2015-3-18 22:111 婵犲痉鏉库偓妤呭Υ鐎n剚顫曟繛鍡樻尭閻愬﹪鏌i幇顒佲枙婵¤尙绮穱濠囧Χ婢跺绱甸柣搴ㄦ涧閻倿寮澶嬫櫢闁跨噦鎷� 闂佽崵濮嶅鍡楊伓 闂佽崵濮嶅鍡楊伓 +1 |
IP: 124.42.70.*   | 闂佽崵濮嶅鍡楊伓 闂佽崵濮嶅鍡楊伓 +1 [1]ljxm   2015-3-18 15:35
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闂備焦鎮堕崕鎶藉磻濞戔懞鍥晸閿燂拷  闂備焦瀵ч崘濠氬箯閿燂拷 闂備胶鍋ㄩ崕鑼垝鎼淬劌姹查柟鐗堟緲鐎氬顭块懜闈涘濮濆洭姊虹粙璺ㄧ妞わ箑宕埢鎾诲箣閿旇棄鍓梺鑺ッˇ顓熺椤栫偞鐓冮柕澶涘缁犳壆绱掗幉瀣
闂備胶鎳撻崲鑼矓閻㈢ǹ绠熸慨妯挎硾閺嬩線鏌涢銈呮灁濞存粠鍨伴埥澶愬箻瀹曞泦銏°亜閳哄瀚�
闂傚倸鍊搁崯顐﹀疮閸ф鍌ㄦ繝濠傜墛閸婂爼鎮归幁鎺戝闁告搩鍓熼弻锝夊Ω閵夈儺浼傞梺纭呭Г閸ㄨ泛顕ラ崟顖氱厴閹煎瓨鎸告禍楣冩煥閻曞倹瀚�
2015-3-18 15:391 婵犲痉鏉库偓妤呭Υ鐎n剚顫曟繛鍡樻尭閻愬﹪鏌i幇顒佲枙婵¤尙绮穱濠囧Χ婢跺绱甸柣搴ㄦ涧閻倿寮澶嬫櫢闁跨噦鎷� 闂佽崵濮嶅鍡楊伓 闂佽崵濮嶅鍡楊伓 +1 |

1/1 | 闂備浇顕栭崜姘i幒妤婃晣闁跨噦鎷�:8 | 濠碘槅鍋撶徊楣冩偋閻樿违闁跨噦鎷� | 濠电偞鍨堕幐鎼佹晝閿濆洨鍗氶悗娑櫱滄禍婊堟煥閻曞倹瀚� | 濠电偞鍨堕幐鎼侇敄閸曨厾鍗氶悗娑櫱滄禍婊堟煥閻曞倹瀚� | 闂備礁鎼悧婊堝磻婵犲洤违闁跨噦鎷� | 闂佽崵濮撮幖顐︽偪閸ヮ灐褰掓晸閿燂拷

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