Molecular hydrogen and radiation protection..pdf

关于氢气治疗疾病的研究报道几乎每周都有更新内容，最近关于各个领域的综述性文章也逐渐增多。刚刚在Free Radic Res. 2012 Apr 27在线发表一篇关于氢气和辐射防护的综述。主要针对氢气在辐射损伤方面的研究，这个方面不仅具有民用价值，而且军事价值也显著，美国太空总署更是把氢气作为太空辐射防护的一种手段，并开展了相关研究。

氢分子作为一种选择性清除毒性自由基羟基自由基的优质抗氧化物质，其有效性被大量的动物疾病模型和临床疾病研究中被反复证明。众所周知，辐射可以使生物体内水被激发大量产生羟基自由基，导致的氧化损伤和细胞凋亡，是辐射损伤的最基本病理生理过程。第二军医大学放射医学研究室在国际上率先报道了氢气在细胞和小鼠辐射损伤中显著保护作用。该效应随后被他们和国际同行在不同的辐射损伤模型中被证实。最近的双盲对照临床研究发现，氢气水对肝脏肿瘤患者临床放射治疗引起典型的人类辐射损伤副作用具有保护作用，可提高患者的生活质量。这些研究结果显示，氢气可以作为一种有效无毒的辐射防护剂

Free Radic Res. 2012 Apr 27. [Epub ahead of print]

Molecular hydrogen and radiation protection.

Chuai Y, Sun X, Cai J.

Abstract Molecular hydrogen (dihydrogen, H(2)) acts as a therapeutic antioxidant by selectively reducing hydroxyl radicals (•OH) and peroxynitrite (ONOO-). It has been well-known that ionizing radiation (IR) causes oxidative damage and consequent apoptosis mainly due to the production of •OH that follows radiolysis of H(2)O. Our department reported the protective effect of H2 in irradiated cells and mice for the first time, and this effect is well repeated by ourselves and another laboratory in different experimental animal models. A randomized, placebo-controlled investigation also showed consumption of H(2) can improve the quality of life of patients treated with radiotherapy for liver tumors. These encouraging results suggested that H(2) has a potential as a radioprotective agent with efficacy and non-toxicity.

 

转载本文请联系原作者获取授权，同时请注明本文来自孙学军科学网博客。
链接地址：https://blog.sciencenet.cn/blog-41174-565004.html

上一篇：再谈航母期刊
下一篇：氢气生物学