曾经有人发表过饮氢气水对动物肝脏基因表达的影响，最近又有人发表相关研究，不过这次是针对氢气是否具有抗衰老，研究的目标组织是海马。氢气来源是珊瑚氢化钙，不知道这个是否与最近国内盛传的负氢离子有没有关系。如果有关系，所谓的负氢离子，本质上不过是氢气的作用，不是什么负氢离子。至少本研究作者是用氢气来解释其效应。另外比较高兴的是，本研究把我们的两篇论文作为参考文献。

研究通过一种早衰动物SAM/P-8，对照动物为SAM/R-1。给动物饲养coral calcium hydride供氢食品，8周龄动物喂养coral calcium hydride和对照食品连续8周，然后取动物海马组织提取mRNA，然后进行基因表达芯片分析，结果发现细胞死亡、炎症反应、氧化应激等基因受到较大影响。研究说明氢气对基因表达确实有比较明显的影响。这与过去氢气生物学效应主要影响细胞死亡、炎症反应和氧化应激是符合的。

这些作者2010年就曾经发表过该物质的研究论文，我也曾经介绍过《通过产氢发挥作用的新型药物》：http://blog.sciencenet.cn/home.php?mod=space&uid=41174&do=blog&id=347691

不过这个研究尽管发现了许多受到影响的基因，但没有采用更严格的技术如PCR和蛋白分析技术进行进一步确认。这给氢气研究领域提供了一个值得挖掘的数据资料。具有非常重要的贡献。

Nutrition Research
Volume 31, Issue 11, November 2011, Pages 863-872

hydrogen science.pdf

Hippocampal gene network analysis suggests that coral calcium hydride may reduce accelerated senescence in mice

Yuto Ueda^{a,  ,  ,}  , Toshio Kojima^b, c,  , Taneaki Oikawa^d, 

Received 26 March 2011; revised 22 August 2011; Accepted 19 September 2011. Available online 24 November 2011.

Abstract

Recent studies strongly support the hypothesis that an antioxidant diet inhibits the pathologic aging process as shown in senescence-accelerated mouse prone 8 (SAM/P-8). In our previous study in coral calcium hydride (CCH), we reported that a diet rich in antioxidants inhibited the pathologic aging process, increased the endogenous antioxidant ability, and contributed to prolonging the lifespan of SAM/P-8. To test the hypothesis that antioxidant CCH supplementation to SAM/P-8 mice would change the gene expression and to understand how CCH reverses the acceleration of aging in SAM/P-8 mice, we used a DNA array to compare the expression levels in the hippocampus of the brains from 16-week-old SAM/P-8 mice that were either treated or not treated with CCH. The most significant up-regulated changes in the gene network of SAM/P-8 mice were free radical scavenging and molecular transport, whereas genes associated with cell death, cancer, and cell cycle were down-regulated. Our findings regarding the changes in these messenger RNA might be associated with the inhibition of the acceleration of aging, as observed in SAM/P-8 mice fed a CCH diet.

Loader.rt("abs_end"); Loader.feature('lp_embed').qCode("loadEmbedContent(EMBED_APC, 'embedAPCModule');") Abbreviations: SAM/P-8, Senescence-accelerated mouse prone 8; CCH, coral calcium hydride; SAM/R-1, Senescence-accelerated mouse resistant/1; PS, phosphatidylserine; AA, arachidonic acid; cDNA, complementary DNA; IPA, Ingenuity Pathway Analysis

Keywords: Senescence-accelerated mouse prone 8 (SAM/P-8); Hydride; antioxidant; Gene; IPA analysis; Hippocampus