身体内气体的释放主要经过呼吸，但也可以通过皮肤，有的动物皮肤的作用就象是呼吸器官，实际上高等动物的皮肤仍具有气体交换的作用，只是这种交换的作用可能不具有生理作用，或者我们不了解其生理作用。氢气是一种可以从大肠吸收的气体，由于这种气体的扩散能力非常强，经过皮肤释放的比例就比较高，因此通过收集皮肤氢气的释放数量，作为临床氢气生物学效应研究的手段，将是一种比较可靠而且容易实现的方式。这至少比通过呼吸检测氢气更容易，而且可以做连续的检测。缺点可能是需要检测的敏感度要高，这可以通过多点检测来进行校正。

最近来自日本的Akito Shimouchi and Kazutoshi Nose 的文章报道了这种方法。这两位作者在2年前曾经做过姜和牛奶可以促进氢气产生的研究。

Akito Shimouchi and Kazutoshi Nose

Biomark Insights. 2009 Feb 9;4:27-32.

Breath hydrogen produced by ingestion of commercial hydrogen water and milk.

Shimouchi A, Nose K, Yamaguchi M, Ishiguro H, Kondo T.

Source

Department of Etiology and Pathogenesis, National Cardiovascular Center Research Institute, Japan.

Abstract

OBJECTIVE:

To compare how and to what extent ingestion of hydrogen water and milk increase breath hydrogen in adults.

METHODS:

Five subjects without specific diseases, ingested distilled or hydrogen water and milk as a reference material that could increase breath hydrogen. Their end-alveolar breath hydrogen was measured.

RESULTS:

Ingestion of hydrogen water rapidly increased breath hydrogen to the maximal level of approximately 40 ppm 10-15 min after ingestion and thereafter rapidly decreased to the baseline level, whereas ingestion of the same amount of distilled water did not change breath hydrogen (p < 0.001). Ingestion of hydrogen water increased both hydrogen peaks and the area under the curve (AUC) of breath hydrogen in a dose-dependent manner. Ingestion of milk showed a delayed and sustained increase of breath hydrogen in subjects with milk intolerance for up to 540 min. Ingestion of hydrogen water produced breath hydrogen at AUC levels of 2 to 9 ppm hour, whereas milk increased breath hydrogen to AUC levels of 164 ppm hour for 540 min after drinking.

CONCLUSION:

Hydrogen water caused a rapid increase in breath hydrogen in a dose-dependent manner; however, the rise in breath hydrogen was not sustained compared with milk.

PMID:

19652760

[PubMed]

PMCID: PMC2716677

Free PMC Article

Related citations

2.

Dig Dis Sci. 2009 Aug;54(8):1725-9. Epub 2008 Nov 26.

Effect of dietary turmeric on breath hydrogen.

Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T.

Source

Department of Etiology and Pathogenesis, National Cardiovascular Center Research Institute, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan. ashimouc@res.ncvc.go.jp

Abstract

Turmeric is widely used in Indian cuisine. The main constituents of turmeric are curcumin and its analogues, which are well-known antioxidant compounds. In the present study, we hypothesized that turmeric in curry might increase bowel motility and activate hydrogen-producing bacterial flora in the colon, thereby increasing the concentration of breath hydrogen. Eight healthy subjects fasted for 12 h and ingested curry and rice with or without turmeric (turmeric knockout curry). Breath-hydrogen concentrations were analyzed every 15 min for 6 h by gas chromatography with a semiconductor detector. Curry with turmeric significantly increased the area under the curve of breath hydrogen and shortened small-bowel transit time, compared with curry not containing turmeric. These results suggested that dietary turmeric activated bowel motility and carbohydrate colonic fermentation.

PMID:

19034660

[PubMed - indexed for MEDLINE]