氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

博文

氢气治疗潜水减压病

已有 6402 次阅读 2011-6-14 00:46 |个人分类:潜水医学|系统分类:论文交流| office, style, color, 潜水

 氢气治疗潜水减压病

Protective effect of hydrogen-rich saline on decompression sickness in rats..pdf

Protective Effect of Hydrogen-Rich Saline on Decompression Sickness in Rats

氢气具有抗氧化应激的作用,而氧化应激在潜水减压病中发挥重要作用(几乎没有什么疾病与氧化没有有关)。本研究为验证氢气生理盐水是否具有预防潜水减压病的作用。研究方法:SD大鼠300-310克制备减压病模型。减压前2412小时、减压时和减压后分别腹腔注射0.86mM氢气生理盐水10ml/kg(按照气体脱饱和理论,2412小时的作用应该非常小)。结果发现,氢气盐水能显著降低减压病发病率(from 67.57 to 35.14%)。肺支气管肺泡灌洗液蛋白含量明显下降(from 0.33 +/- 0.05 to 0.14 +/- 0.01 mg /mlMPO活性明显下降(from 0.86 +/- 0.16 to 0.44 +/- 0.13 U/g),肺组织MDA8-OHdG明显下降。脊髓MDA明显下降。组织学改变显示氢气盐水能降低减压病组织损伤。结论:氢气盐水对潜水减压病可能具有治疗作用。

本研究具有重要意义:氢气本身就可用于潜水作业,既然氢气具有预防潜水减压病的作用,不仅对人们理解氢气潜水的意义,而且对氢气在其他类型潜水作业中都具有重要意义。例如在空气潜水前或减压过程或减压结束后,都可以适当给潜水员呼吸或饮用一定氢气或水。对大深度饱和潜水,更可以直接把氢气作为一种呼吸气体直接使用。

 

Introduction: Hydrogen (H-2) has been reported to be effective in the treatment of oxidative injury, which plays an important role in the process of decompression sickness (DCS). This study was designed to test whether H-2-rich saline (saline saturated with molecular hydrogen) protected rats against DCS. Methods: Models of DCS were induced in male Sprague-Dawley rats weighing 300-310 g. H-2-rich (0.86 mmol . L-1) saline was administered intraperitoneally (10 ml . kg(-1)) at 24 h, 12 h, immediately before compression, and right after fast decompression. Results: H-2-rich saline significantly decreased the incidence of DCS from 67.57 to 35.14% and partially counteracted the increases in the total concentration of protein in the bronchoalveolar lavage from 0.33 +/- 0.05 to 0.14 +/- 0.01 mg . ml(-1) (mean +/- SD; P < 0.05), myeloperoxidase activity from 0.86 +/- 0.16 to 0.44 +/- 0.13 U/g, levels of malondialdehyde (MDA) from 0.80 +/- 0.10 to 0.48 +/- 0.05 nmol . mg(-1), 8-hydroxydeoxyguanosine from 253.7 +/- 9.3 to 191.2 +/- 4.8 pg . mg(-1) in the lungs, and MDA level from 1.77 +/- 0.20 to 0.87 +/- 0.23 nmol . mg(-1) in the spinal cord in rat DCS models. The histopathology results also showed that H-2-rich saline ameliorated DCS injuries. Discussion: It is concluded that H-2-rich saline may have a protective effect against DCS, possibly due to its antioxidant action.

 

 



https://blog.sciencenet.cn/blog-41174-454917.html

上一篇:如何提高研究生导师质量
下一篇:氢气生物学面临的挑战
收藏 IP: 151.112.127.*| 热度|

7 郑永军 许培扬 张南希 郭桅 谢鑫 luofalai zhangling

该博文允许注册用户评论 请点击登录 评论 (0 个评论)

1/0 | 闂傚倸鍊搁崐鎼佸磹閹间礁纾归柟闂寸绾惧湱鈧懓瀚崳纾嬨亹閹烘垹鍊炲銈嗗笒椤︿即寮查鍫熲拺闁告繂瀚埢澶愭煕濡灝浜圭紒顔肩墦瀹曞ジ鎮㈢粙鍨紟婵犳鍠楅〃鍛涘Δ鍛闁挎洖鍊归悡銉︾節闂堟稒锛嶆俊鎻掓憸缁辨帡鎮╅悜妯煎涧婵烇絽娲ら敃顏呬繆閸洖妞介柛鎰ㄦ櫆閺嗕即姊绘担鍛婃儓闁归攱鍨圭槐鐐存媴閸撳弶缍庨梺鎯х箺椤鐣锋径鎰厪濠电偛鐏濋崝婊堟煟濠靛嫬鐏叉慨濠冩そ閹兘寮堕幐搴敤闂備胶鎳撻崵鏍箯閿燂拷:0 | 濠电姷鏁告慨鐑藉极閸涘﹥鍙忛柣鎴濐潟閳ь剙鍊块幐濠冪珶閳哄绉€规洏鍔戝鍫曞箣閻欏懐骞㈤梻鍌欐祰椤鐣峰Ο琛℃灃婵炴垶纰嶉浠嬫煏閸繃鍟掗柡鍐ㄧ墛閺呮煡鏌涘☉鍗炲箺婵炲牊鐓″铏圭矙濞嗘儳鍓板銈嗗灥椤﹂潧顕f繝姘櫜闁告稑鍊婚崰搴ㄥ煝鎼淬劌绠氱憸搴敊閸曨垱鐓涘璺烘濞呭棛绱掔拠鑼妞ゎ偄绻橀幖鍦喆閸曨偆锛忛梻渚€娼ф灙闁稿孩鐓¢幃鐢稿閵堝棌鎷洪梺鑽ゅ枑濠㈡ê鈻撻埡鍛厵闁告垯鍊栫€氾拷 | 濠电姷鏁告慨鐑藉极閸涘﹥鍙忛柣鎴f閺嬩線鏌熼梻瀵割槮缁炬儳顭烽弻锝夊箛椤掍焦鍎撻梺鎼炲妼閸婂潡寮诲☉銏╂晝闁挎繂妫涢ˇ銉х磽娴e搫小闁告濞婂濠氭偄閸忓皷鎷婚柣搴f暩鏋┑鈥茬矙濮婃椽宕崟顒€娅ょ紓浣筋嚙閻楁挸顕f繝姘╅柕澶堝灪閺傗偓闂備胶纭堕崜婵嬫晪缂備焦鍔栭惄顖氼潖濞差亜宸濆┑鐘插閻g兘鎮楅崗澶婁壕闂佸綊妫跨粈浣虹不閺嶃劋绻嗛柕鍫濆€告禍楣冩⒑鐎圭姵顥夋い锔诲灦閸┿垹顓奸崱妯肩Ф闂侀潧臎閸涱垰甯掔紓鍌氬€风粈渚€宕愰崫銉х煋闁圭虎鍠撻崑鎴澝归崗鍏肩稇闂佸崬娲弻锝夊棘閹稿孩鍎撻悗娈垮枟婵炲﹤顫忕紒妯诲闁惧繒鎳撶粭鈥斥攽閻愭彃绾ч柣妤冨Т閻g兘骞囬弶鎸庡祶濡炪倖鎸荤粙鎴炵閻愵剚鍙忔俊顖滃帶娴滈箖鎮楀鐐 | 闂傚倸鍊搁崐鎼佸磹閹间礁纾圭€瑰嫭鍣磋ぐ鎺戠倞鐟滃繘寮抽敃鍌涚厱妞ゎ厽鍨垫禍婵嬫煕濞嗗繒绠婚柡宀€鍠撶槐鎺楀閻樺磭浜紓鍌欒兌婵箖锝炴径鎰﹂柛鏇ㄥ灠缁犳盯鏌涢锝嗙妞ゅ骸绉瑰铏圭矙濞嗘儳鍓炬繛瀛樼矤娴滎亜顕g拠娴嬫闁靛繒濮堥妸锔轰簻闁哄倸鐏濈紞鏍ㄦ叏鐟欏嫷娈滈柟顔煎槻楗即宕ㄩ褎姣夐梺姹囧焺閸ㄩ亶銆冩繝鍌ゅ殨闁哄被鍎辩粻鐟懊归敐鍛础闁告瑥妫濆铏圭磼濡崵顦ラ梺绋匡工濠€閬嶅焵椤掍胶鍟查柟鍑ゆ嫹

扫一扫,分享此博文

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2025-1-23 05:12

Powered by ScienceNet.cn

Copyright © 2007-2025 中国科学报社

返回顶部