氢气分子医学文献汇总（全文并持续更新） 

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             为了方便本领域的同行随时阅读文献，这里专门整理全部氢分子医学的文献，包括论著、综述和评述，如果有遗漏，请大家提醒我补充，谢谢。适合读者，包括从事自由基化学、生物学的所有人员，对自身和他人健康防护有兴趣的读者。

1.        Dole M, Wilson FR, Fife WP.Hyperbaric hydrogen therapy: a possible treatment for cancer. Science, 1975; 190(4210):152-4.pdf

2.        Buxton, GV, Greenstock, CL., Helman, W.P. et al. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution. J Phys Chem,1988; 513–886. pdf

3.        Kayar SR, Axley MJ, Homer LD, et al. Hydrogen gas is not oxidized by mammalian tissues under hyperbaric conditions.Undersea Hyperb Med, 1994; 21(3):265-75.pdf

4.        Gharib B, Hanna S, Abdallahi OM, et al.Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.C R Acad Sci III, 2001; 324(8):719-24. pdf

5.        Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med, 2007; 13: 688-94. pdf scopus

6.        Katherine C, Wood, Mark T Gladwin. The hydrogen highway to reperfusion therapy. Nat Med, 2007; 13: 673-4. pdf

7.        Fukuda KI, Asoh S, Ishikawa M, et al. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun, 2007; 361: 670-4 pdf

8.        Ball J.Recently published papers: more about EGDT, experimental therapies and some inconvenient truths. Crit Care. 2007;11(5):171.pdf review

9.        Singhal AB, Lo EH. Advances in emerging nondrug therapies for acute stroke 2007. Stroke. 2008; 39(2):289-91.pdf review

10.    Buchholz BM, Kaczorowski DJ, Sugimoto R, et al. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury.Am J Transplant. 2008; 8(10):2015-24 pdf

11.    Cai JM, Kang ZM, Liu W, et al. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci lett 2008,441(2):167-72 pdf

12.    Hayashida K, Sano M, Ohsawa I, et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun, 2008,373(1):30-5.pdf

13.    Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance, Nutr. Res, 2008,28:137-43 pdf

14.    Ohsawa I, Nishimaki K, Yamagata K, et al. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice.Biochem Biophys Res Commun, 2008, 377(4):1195-8 pdf

15.    Sato Y, Kajiyama S, Amano A, et al. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun, 2008; 375(3):346-50. pdf

16.    Rochette Luc, Catherine Vergely. Forgotten Radicals in Biology. Int J Biomed Sci. 2008; 4( 4):255-9. pdf  review

17.    Sun XJ, Zhang JH. Hydrogen-- an endogenous antioxidant in the body. 第二军医大学学报, 2008; 29: 233-5. pdf  review

18.    Ohta S.Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept. Nippon Ronen Igakkai Zasshi. 2008;45(4):355-62. medline  pdf review

19.    Nakao A, Sugimoto R, Billiar TR, McCurry KR.Therapeutic antioxidant medical gas. J Clin Biochem Nutr. 2009;44(1):1-13.pdf  review

20.    Nagata K, Nakashima-Kamimura N, Mikami T, et al. Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology. 2009; 34(2):501-8. pdf

21.    Cai JM, Kang ZM, Liu K, et al. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res. 2009;1256:129-37.pdf

22.    Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S.Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.Cancer Chemother Pharmacol. 2009; 64(4):753-61. pdf

23.     Zheng XF, Mao YF, Cai JM, Li YH, Liu WW, Sun PL, Zhang JH, Sun XJ, Yuan.HB Hydrogen-Rich Saline Protects against Intestinal Ischemia/Reperfusion Injury in Rats Free Radical Res.2009; 43(5):478-84. pdf

24.    Fu Y, Ito M, Fujita Y, et al. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neurosci lett. 2009; 453(2):81-5. pdf

25.    Matchett GA, Fathali N, Hasegawa Y, et al. Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models.Brain Res. 2009; 1259:90-7. pdf

26.    Mao YF, Zheng XF, Cai JM, et al. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun.2009; 381(4):602-5. pdf

27.    Akito Shimouchi, Kazutoshi Nose, Makoto Yamaguchi, Hiroshi Ishiguro  Takaharu Kondo. Breath Hydrogen Produced by Ingestion of Commercial Hydrogen Water and Milk.Biomarker Insights 2009:4 27-32. pdf

28.    Kikkawa YS, Nakagawa T, Horie RT, Ito J.Hydrogen protects auditory hair cells from free radicals.Neuroreport. 2009;20(7):689-94. pdf

29.    Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K. Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett. 2009; 583(13):2157-9. pdf 

30.    Kajiya M, Sato K, Silva MJ, Ouhara K, Do PM, Shanmugam KT, Kawai T. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun. 2009; 386(2):316-21. pdf

31.    Kajiya M, Silva MJ, Sato K, Ouhara K, Kawai T. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun. 2009 Aug 14;386(1):11-5. 2009; 386(1):11-5. pdf

32.    Sun Q, Kang ZM, Cai JM, Liu WW, Liu Y. Zhang JH, Denoblec PJ, Tao HY, Sun XJ.Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats Exp Biol Med.2009; in press pdf

33.    Chen H, Sun YP, Hu PF, Liu WW, Xiang HG, Li Y,Yan RL, Su N, Ruan CP, Sun XJ, Wang Q.The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. J Surg Res.2009; in press pdf

34.    Milton SL.HYDROGEN SALINE A REAL GAS. J Exp Biol. 2009 in press pdf comment to our paper

35.  Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T.Effect of dietary turmeric on breath hydrogen. Dig Dis Sci. 2009 Aug;54(8):1725-9. Epub 2008 Nov 26 pdf

36. Xu J, Zhou JR, Cai JM, Zhu Z, Sun XJ, Jiang CL.Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. Inflammation Res.2009 in press pdf

37.  Itoh T, et al. Molecular hydrogen suppresses FcεRI-mediated signal transduction and preventsdegranulation of mast cells. Biochem Biophys Res Commun. 2009. in press  pdf

38.  Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, et al. Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease. PLoS ONE. 2009; 4(9): e7247. doi:10.1371/journal.pone.0007247 pdf

39. Y. Saitoh, Y. Yoshimura, K. Nakano, N. Miwa. Platinum nanocolloid-supplemented hydrogendissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells.Experimental Oncology 31, 156–162, 2009 pdf

40.  Nakao, A, Kaczorowski, D J, Wang, Y, Cardinal, J S, Buchholz, B M, Sugimoto, R, Tobita, K, Lee, S, Toyoda, Y, Billiar, T R, McCurry, K R. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant. 2010 May;29(5):544-53. Epub 2009 Dec 24. pdf

41.  Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, Wang G.. Protective Effects of Hydrogen Gas on Murine Polymicrobial Sepsis via Reducing Oxidative Stress and HMGB1 Release. Shock. 2010 Jul;34(1):90-7. pdf

42.  Oharazawa H et al.Rapid Diffusion of Hydrogen Protects the Retina: Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury.  Investigative Ophthalmology & Visual Science  2010;51:487-492  pdf

43.  Qian L, Cao F, Cui J, Huang Y, Zhou X, Liu S, Cai J. Radioprotective effect of hydrogen in cultured cells and mice. Free Radical Res. 2010;44:275-82   pdf

44. Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A.Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 2010;77(2):101-9. pdf

45.    George JF, Agarwal A.Hydrogen: another gas with therapeutic potential. Kidney Int. 2010 Jan;77(2):85-7. pdf

46.  Liu C, Cui JG, Sun Q, Cai JM. Hydrogen therapy may be an effective and specific novel treatment  for  acute radiation  syndrome. Medical Hypotheses.2010;74:145-146  pdf

47. Chen H, Sun YP, Li Y, Liu WW, Xiang HG, Fan LY, Sun Q, Sun XJ, Wang Q. Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun.2010; 393:308-13 pdf

48.    LI J, WANG C, Zhang JH, CAI JM, CAO YP, SUN XJ. Hydrogen-rich Saline Improves Memory Function in a Rat Model of Amyloid-beta-induced Alzheimer’s Disease by Reduction of Oxidative Stress.Brain res.2010; pdf

49.    Shen MH, Cai JM, Sun Q, He J, Sun XJ, Huo ZL. Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses.2010 pdf in press

50.    Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N.Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010 Mar;46(2):140-9. Epub 2010 Feb 24. pdf  [Abstract] [PDF (250K)] 

51.     Saitoh Y, Harata Y, Mizuhashi F, Nakajima M, Miwa N. Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity. Toxicol Ind Health. 2010 Mar 4. [Epub ahead of print]  pdf

52.    Chen CW, Chen QB, Mao YF, Xu SM, Xia CY, Shi XY, Zhang JH, Yuan HB, Sun XJ. Hydrogen-rich saline protects against spinal cord injury in rats.Neurochem Res. 2010;in press pdf

 53. Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, Zhou WP, Shen RX, Yang JM, Sun XJ. Hydrogen-Rich Saline Protects against Liver Injury in Rats with Obstructive Jaundice.Liver International 2010 pdf

54.    Xie K, Yu Y, Zhang Z, Liu W, Pei Y, Xiong L, Hou L, Wang G. HYDROGEN GAS IMPROVES SURVIVAL RATE AND ORGAN DAMAGE IN ZYMOSAN-INDUCED GENERALIZED INFLAMMATION MODEL. Shock. 2010 Mar 23. pdf

55.  C.H. Chen, M. Anatol, Y. Zhan, W.W. Liu, R.P. Ostrowki, J. Tang, J.H. Zhang. Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model Neuroscience. 2010; In Press, pdf

56.    Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S. A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial. Nephrol Dial Transplant. 2010 Apr 12. pdf 

57. Zheng J, Liu K, Kang Z, Cai J, Liu W, Xu W, Li R, Tao H, Zhang JH, Sun X. Saturated hydrogen saline protects lung against oxygen toxicity. Undersea Hyperb Med. 2010;37(3):185-92. pdf

58.    Shingu C, Koga H, Hagiwara S, Matsumoto S, Goto K, Yokoi I, Noguchi T. Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. J Anesth. 2010 May 18. [Epub ahead of print] PDF

59.    Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, Nakao A. Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice. J Clin Biochem Nutr. 2010 May;46(3):269-76. Epub 2010 Apr 23. pdf web

60.    Kitamura A, Kobayashi S, Matsushita T, Fujinawa H, Murase K. Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. Br J Radiol. 2010 Jun;83(990):509-14.pdf

61.    Haruhisa Kawasaki, Jianjun Guan, Kenichi Tamama. Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials Biochemical and Biophysical Research Communications, 2010 pdf

62.     Chen QB et al. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress and BDNF in spinal cord in a chronic constriction injury rat model. Brain res.2010; 35(7):1111-8 pdf. pdf

63. Huang et al. Hydrogen Gas Inhalation Attenuates Ventilator-Induced Lung Injury In Mice. Am. J. Respir. Crit. Care Med..2010; 181: A3751 ms

64.   Ji X, Liu W, Xie K, Liu W, Qu Y, Chao X, Chen T, Zhou J, Fei Z.Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain res. 2010 pdfl

65.  Ueda Y, Nakajima A, Oikawa T. Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride. Neurochem Res. 2010 Jul 22. pdf 

65.    Domoki F, Oláh O, Zimmermann A, Németh I, et al. Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs. Pediatric Research. 2010. pdf

66. Liu SL, Tao HY, Sun Q, Sun XJ. Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury. Medical Hypotheses. 2010; in press pdf pdf

67.     Qian LR, li BL, Cao F, Huang YC, Liu SL, Cai JM, Gao F. HYDROGEN-RICH PBS PROTECTS CULTURED HUMAN CELLS FROM IONIZING RADIATION-INDUCED CELLULAR DAMAGE. Nuclear Technology &Radiation Protection.2010 pdf

68.   Zhang YF, Sun Q, He B, Xiao J, Wang ZN, Sun XJ. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. International Journal of Cardiology.2010; pdf

69. Huang CS, Kawamura T, Toyoda Y, Nakao A.Recent advances in hydrogen research as a therapeutic medical gas. Free Radic Res. 2010 Sep;44(9):971-82. pdf review

70.  Schoenfeld MP, Ansari RR, Zakrajsek JF, Billiar TR, Toyoda Y, Wink DA, Nakao A Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.Medical Hypotheses. 2010; pdf in press

71.    Sun Q, Cai JM, Liu SL, Liu Y, Xu WG, Tao HY, Sun XJ. Hydrogen-rich saline provides protection against hyperoxic lung injury. J Surg Res. 2011;165:e43–e49  pdf offprint

72.     Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci. 2010 Sep 16. pdf

73.    Chen X, et al. Lactulose: an indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production. Medical Hypotheses 2010 pdf1

74.    Sun H, Chen L, Zhou W, Hu L, Li L, Tu Q, Chang Y, Liu Q, Sun X, Wu M, Wang H.The Protective Role of Hydrogen -Rich Saline in Experimental Liver Injury in Mice. j hepatology. 2010; pdf

75.   Lin Y, Kashio A, Sakamoto T, Suzukawa K, Kakigi A, Yamasoba T. Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neurosci Lett. 2010; pdf

76.  Sun Q, Cai JM,Zhou JR,Tao HY,Zhang JH,Zhang W,Sun XJ.Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Critical Care Medicine. 2010 in press

77.  Wang F, Yu G, Liu SY, Li JB, Wang JF, Bo LL, Sun XJ, Deng XM.Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats. J Surg Res.2010; in press

78.  Kawamura T, Huang CS, Tochigi N, Lee S, Shigemura N, Billiar TR, Okumura M, Nakao A, Toyoda Y.Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats. Transplantation. 2010 Nov 2. [Epub ahead of print] pdf

79.  Li Y, Hamasaki T, Nakamichi N, Kashiwagi T, Komatsu T, Ye J, Teruya K, Abe M, Yan H, Kinjo T, Kabayama S, Kawamura M, Shirahata S.Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology. 2010 Nov 10. [Epub ahead of print] pdf

80.    Yan H, Tian H, Kinjo T, Hamasaki T, Tomimatsu K, Nakamichi N, Teruya K, Kabayama S, Shirahata S. Extension of the lifespan of Caenorhabditis elegans by the use of electrolyzed reduced water. Biosci Biotechnol Biochem. 2010 Oct 23;74(10):2011-5. pdf

81.  Fang Y. Fu XJ, Gu C, Xu P, Wang Y, Yu WR, Sun Q, Sun XJ, Yao M. Hydrogen-Rich Saline Protects against Acute Lung Injury Induced by Extensive Burn in Rat Model. J Burn Care Res.

82.   Qian L, Cao F, Cui J, Wang Y, Huang Y, Chuai Y, Zaho L, Jiang H, Cai J.The potential cardioprotective effects of hydrogen in irradiated mice. J Radiat Res (Tokyo). 2010;51(6):741-7 pdf

83.    Huang Y, Xie KL, Li JP, Xu N, Gong G, Wang GL, Yu YH, Dong HL, Xiong LZ. Beneficial Effects of Hydrogen Gas against Spinal Cord Ischemia-Reperfusion Injury in Rabbits. Brain res. 2011; in press

84.   Qian LR, Li BL, Cai JM, Gao F. The Hypothesis of an Effective Safe and Novel Radioprotective Agent Hydrogen-rich Solution  West Indian Med J. 2010; 59 (2): 122-4

85. Taura A, Kikkawa YS, Nakagawa T, Ito J. Hydrogen protects vestibular hair cells from free radicals. Acta Otolaryngol Suppl. 2010;563:95-100. pdf

86.    Zhu WJ et al. Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. Nephrol. Dial. Transplant. (2010) doi: 10.1093/ndt/gfq727 pdf

87.    Liu SL, Liu K, Sun Q, Liu WW, Xu WG, Denoble P, Tao HY, Sun XJ. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. J Biomed Biotechnol. 2011;

88.  Hong Y, Chen S, Zhang JM. Hydrogen as a Selective Antioxidant: a Review of Clinical and Experimental Studies.J Int Med Res. 2010; 38: 1893-1903 pdf

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89        Wang C, Li J, Liu Q, Yang R, Zhang JH, Cao YP, Sun XJ. Hydrogen-rich Saline Reduces Oxidative Stress and Inflammation by Inhibit of JNK and NF-κB Activation in a Rat Model of Amyloid-beta-induced Alzheimer's Disease. Neurosci Lett. 2011 Jan 13. [Epub ahead of print]