Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic …

I Ohsawa, M Ishikawa, K Takahashi, M Watanabe, K … - Nature medicine, 2007 - nature.com
Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage
to tissues, and persistent oxidative stress is accepted as one of the causes of many common
diseases including cancer. We show here that hydrogen (H 2 ) has potential as an ...
被引用次数：76 - 相关文章

这个文章是属于bible级的论文，从引用量上可以看出了。该论文首先在国际上公布呼吸2%的氢气可以治疗脑缺血在灌注损伤，分别从动物模型、各种细胞学、和化学反应等层面，证明氢气是选择性与毒性自由基直接反应，从而具有抗氧化损伤的作用。从该研究出发，非常容易能引申出呼吸氢气对其他各类器官再灌注损伤，各类炎症反应可能具有治疗作用。

这个发表在Nature medicines上的文献将是该领域永远热点论文，几乎所有的文章都引用它。

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial …

K Hayashida, M Sano, I Ohsawa, K Shinmura, K … - Biochemical and …, 2008 - Elsevier
Inhalation of hydrogen (H 2 ) gas has been demonstrated to limit the infarct volume of brain and
liver by reducing ischemia–reperfusion injury in rodents. When translated into clinical
practice, this therapy must be most frequently applied in the treatment of patients with ...
被引用次数：38 - 相关文章 - 所有 6 个版本

来自同一个实验室。属于第一篇的姐妹篇，唯一的区别是采用心脏缺血模型。发表杂志BBRC

Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/ …

h4o.jp [PDF]
K Fukuda, S Asoh, M Ishikawa, Y Yamamoto, I … - Biochemical and …, 2007 - Elsevier
We have recently showed that molecular hydrogen has great potential for selectively reducing
cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen
gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. ...
被引用次数：34 - 相关文章 - 所有 13 个版本

来自同一个实验室。属于第一篇的姐妹篇，唯一的区别是采用肝脏缺血模型。

注意这是2007年的文章。发表杂志BBRC

[PDF] Hydrogen inhalation ameliorates oxidative stress in transplantation induced …

sciencetimes.com.cn [PDF]
BM Buchholz, DJ Kaczorowski, R Sugimoto, R … - Am J …, 2008 - sciencetimes.com.cn
Ischemia/reperfusion (I/R) injury during small intesti- nal transplantation (SITx) frequently causes
complica- tions including dysmotility, inflammation and organ failure. Recent evidence indicates
hydrogen inhalation eliminates toxic hydroxyl radicals. Syngeneic, ortho- topic SITx was ...
被引用次数：32 - 相关文章 - HTML 版 - 所有 22 个版本

这个文章的特点：美国第一篇，选择的器官是小肠，选择的模型是移植，选择的指标是炎症反应。这三个特点决定了这个文献将是该领域的热点论文。

[PDF] Supplementation of hydrogen-rich water improves lipid and glucose …

watersurvey.org [PDF]
S Kajiyama, G Hasegawa, M Asano, H … - … BALANCE: ROLE IN …, 2008 - watersurvey.org
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with
type 2 diabetes or impaired glucose tolerance Sizuo Kajiyama a, b, Goji Hasegawa b,?, Mai
Asano b, Hiroko Hosoda b, Michiaki Fukui b, Naoto Nakamura b, Jo Kitawaki c, Saeko ...
被引用次数：25 - 相关文章 - HTML 版 - 所有 25 个版本

是喝8周含氢气水对糖尿病患者脂肪和糖代谢影响的初步观察。这个文献的特点是该领域的第一篇人体试验，这决定了该文献的重要地位。

Consumption of molecular hydrogen prevents the stress-induced impairments in …

sciencenet.cn [PDF]
K Nagata, N Nakashima-Kamimura, T Mikami, … - …, 2008 - nature.com
We have reported that hydrogen (H 2 ) acts as an efficient antioxidant by gaseous rapid
diffusion. When water saturated with hydrogen (hydrogen water) was placed into the stomach
of a rat, hydrogen was detected at several M level in blood. Because hydrogen gas is ...
被引用次数：23 - 相关文章 - 所有 22 个版本

该文章是用含氢气水对大鼠应激后神经损伤的治疗作用，特点是对该领域从缺血再灌注向应激后损伤进行了扩展。实验中观察了海马损伤与神经再生。发表在神经精神药理学杂志上。

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin …

sciencenet.cn [PDF]
Y Sato, S Kajiyama, A Amano, Y Kondo, T … - Biochemical and …, 2008 - Elsevier
Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism
of hydrogen's effect in the brain, we administered hydrogen-rich pure water (H 2 ) to senescence
marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot ...
被引用次数：19 - 相关文章 - 所有 14 个版本

这个文章的重要性是对氢气的选择性抗氧化提出了挑战，但声音不强。动物模型是比较特殊的。发表在BBRC

Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model

159.226.26.14 [PDF]
J Cai, Z Kang, WW Liu, X Luo, S Qiang, JH Zhang, S … - Neuroscience …, 2008 - Elsevier
Hypoxia–ischemia (HI) brain injury is a major cause of neuronal cell death especially apoptosis
in the perinatal period. This study was designated to examine the effect of hydrogen therapy
on apoptosis in an established neonatal HI rat pup model. Seven-day-old rat pups were ...
被引用次数：17 - 相关文章 - 所有 11 个版本

这个文章采用不同的脑缺血模型，证明呼吸氢气对新生儿脑缺血具有治疗作用。重要的是，这是除日本美国以外的地区发表的第一篇论文。

Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E …

I Ohsawa, K Nishimaki, K Yamagata, M … - Biochemical and …, 2008 - Elsevier
Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants
failed to show marked success in preventing atherosclerotic diseases. We have found that hydrogen
(dihydrogen; H 2 ) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, ...
被引用次数：14 - 相关文章 - 所有 5 个版本

这个文章是对动脉硬化的治疗作用，扩展了研究领域。发表在BBRC

Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model

sciencenet.cn [PDF]
J Cai, Z Kang, K Liu, WW Liu, RP Li, JH Zhang, X Luo, … - Brain research, 2009 - Elsevier
Cerebral hypoxia–ischemia (HI) represents a major cause of brain damage in the term
newborn. This study aimed to examine the short and long-term neuroprotective effect of hydrogen
saline (H 2 saline) using an established neonatal HI rat pup model. Seven-day-old rat ...
被引用次数：9 - 相关文章 - 所有 10 个版本  

这是2009年唯一进入排行榜的论文。特色是：采用注射含氢气生理盐水作为给氢气的手段，属于在实验技术上的革新，给临床应用提供了更多遐想。

经典论文待续

 氢气生物学导读