这是最新的一篇综述,建议仔细阅读:
The Role of Methane in Intestinal Diseases
从基本道理讲,甲烷应该属于生物活性分子。zh
从生命的起源,由于原始大气的成分中这个气体是最原始的有机物质,早就被生物学家看中。
从低等生物看,这个气体是许多细菌的代谢产物,沼气是人所共知的事实,说明在细菌,甲烷肯定非常重要。
前几年有人发现,许多高等植物也能产生这个气体,更有人发现高等动物的有些细胞也能产生这个气体。
但人们一直没有注意到它在高等动物中具有什么生物学意义,现在已经开始有人关注了,先是对消化系统。可以预见,这个气体绝对不可能只对一个系统有作用,因为它能进入全身各个地方,分子量小。我相信一定有很多有意思的研究等着我们。
最近的一个综述,先了解一下吧:
Methane and the Gastrointestinal Tract.
Abstract: INTRODUCTION: Several gases are produced through enteric fermentation in the intestinal tract. Carbon dioxide, hydrogen, hydrogen sulfide, and methane are thought to be the most common of these. Recent evidence suggests that methane may not be inert. In this review article, we summarize the findings with methane. METHODS: This is a review article discussing the various component gases in the gastrointestinal tract and their relevance to health and disease. Specific attention was paid to understanding methane. RESULTS: The majority of these gases are eliminated via flatus or absorbed into systemic circulation and expelled from the lungs. Excessive gas evacuation or retention causes gastrointestinal functional symptoms such as belching, flatulence, bloating, and pain. Between 30 and 62% of healthy subjects produce methane. Methane is produced exclusively through anaerobic fermentation of both endogenous and exogenous carbohydrates by enteric microflora in humans. Methane is not utilized by humans, and analysis of respiratory methane can serve as an indirect measure of methane production. Recent literature suggests that gases such as hydrogen sulfide and methane may have active effects on gut function. In the case of hydrogen sulfide, evidence demonstrates that this gaseous product may be produced by human eukaryotic cells. However, in the case of methane, there is increasing evidence that this gas has both physical and biological effects on gut function. It is now often associated with functional constipation and may have an active role here. CONCLUSION: This review of the literature discusses the significance of enteric flora, the biogenesis of methane, and its clinical associations. Furthermore, we examine the evidence for an active role of methane in gastrointestinal motility and the potential applications to future therapeutics.
关于正常人屁的气体成分,提供了一个重要资料
氢气的大部分被人体吸收,剩余中,主要保留在肠道内,但不少