氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

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氢气是新的具有潜在临床应用价值的气体

已有 6857 次阅读 2010-1-23 11:57 |个人分类:氢气生物学|系统分类:科研笔记| 氢气

       在肾脏国际杂志上,最近有一篇评论文章,题目是“氢气:另一个具有治疗潜力的气体”。该文章是对同一杂志美国匹大移植中心关于含氢水治疗移植后肾病论文的评论。这是目前美国对氢气研究最前沿的小组,负责人是日裔教授Nakao,他们已经先后发表了氢气对小肠、心脏和肾脏移植方面的文章,可以说是移植与氢气方面具有特点。这个评论文章没有看到全文,从摘要看没有什么值得看的内容。 本文的日文全文 [PDF] 水素―新しい治療的医学ガスhra-japan.org [PDF]
JF George, A Agarwal - hra-japan.org
Page 1. 編集者の論評 (掲載論文の解説) 水素―新しい治療的医学ガス James F.
George1,3 and Anupam Agarwal2,3 1Department of Surgery, Division of Cardiothoracic
Surgery and the 2Department of Medicine, Division of Nephrology ...

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Hydrogen: another gas with therapeutic potential

James F George & Anupam Agarwal

Abstract

Cardinal and colleagues describe the use of molecular hydrogen, the most abundant molecule in the universe, as a treatment for chronic allograft nephropathy (CAN) in a rat model of kidney transplantation. They demonstrate that the addition of hydrogen to the drinking water results in a decrease in the severity of CAN and increased graft survival, and they provide evidence that the mechanism of action could be due to a reduction in reactive oxygen species. Kidney International (2010) 77, 85–87. doi:10.1038/ki.2009.432

图中的观点需要商榷,氢气目前不能证明能中和超氧自由基。

Given
previous data, the interpretation that the
benefi cial eff ects of H 2 in a kidney transplant
model are a result of antioxidant
properties of the element is reasonable
and likely. However, this may not be the
sole explanation, and other as-yet undefi
ned mechanisms may be involved. Th e
presence of basal levels of H 2 indicates one
or more endogenous sources, suggesting
that it plays a physiological role. Precedent
for this possibility can be easily found in
other gas-generating systems.

Therefore, given the
increasing number of systems in which H 2
is being shown to mediate beneficial
eff ects, and likely, in the future, deleterious
ones as well, it is probable that involvement
of H 2 in signaling pathways or other
physiological functions will be found.



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