博文
氢气小剂量连续给药治疗巴金森病效果显著
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该文在PLoS ONE杂志上发表，应该是07年日本在NM报道氢气效应后最高档杂志，主要的特点是发现连续（8小时/天）小剂量（0.08ppm）给动物饮用1/20饱和浓度(1.5ppm)的含氢水对MPTP诱导的巴金森病治疗效果显著。这个研究对推动含氢水作为保健品和药物都具有重大影响。过去大家在研究这个领域时候，一般都趋向认为需要增大氢浓度，以实现更好的效果，而由于氢气容易在溶液中释放出来，浓度很容易降低，因此担心会影响效果。现在看来不需要担心这个问题，因为只要连续给药，即使很低浓度也同样有效果。
这个研究有其他重要启示：内源性氢气的效果比预想的更重要，因为体内的浓度与这个更接近。另外给药物开发带来福音，因为浓度越低，需要的工程技术越低，不仅对制备技术，而且对保存和运输技术都降低了要求。也对过去一次“大”剂量间断给药的效果给了一个非常重要的说明，因为一次比较大的剂量后虽然很快降低，但能保持有效浓度的时间要明显延长。过去认为只能维持30分钟，现在至少可以维持到6小时，因为有效浓度比过去认为的要低20倍。甚至更低，因为让动物自由饮用，浓度仍要持续下降。
因此这个文章将对推动氢分子医学具有重要影响。
实际上去年日本已经有人采用类似的模型研究同一个疾病，http://www.sciencenet.cn/m/user_content.aspx?id=215765。两个研究思路非常类似，但文章只发表在一个很一般的杂志上，因此研究的思路本身固然重要，研究的技术和精细程度也是非常重要的。从这两个文章的对比，我们应有所思考：我们是否需要更开放的思维和更认真的态度。
作者信息：年轻的Noda副教授
http://hyoka.ofc.kyushu-u.ac.jp/search/details/K000835/english.html
Hydrogen in Drinking Water Reduces DopaminergicNeuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease
Kyota Fujita1, Toshihiro Seike1, Noriko Yutsudo2, Mizuki Ohno2, Hidetaka Yamada2, Hiroo Yamaguchi2,
Kunihiko Sakumi2, Yukiko Yamakawa1, Mizuho A. Kido3, Atsushi Takaki4, Toshihiko Katafuchi4,
Yoshinori Tanaka5, Yusaku Nakabeppu2., Mami Noda1.*
1 Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, 2 Division of Neurofunctional Genomics, Medical
Institute of Bioregulation, Kyushu University, Fukuoka, Japan, 3 Department of Oral Anatomy and Cell Biology, Graduate School of Dental Sciences, Kyushu University,
Fukuoka, Japan, 4 Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 5 R&D Center, Home Appliances
Manufacturing Business Unit, Panasonic Electric Works Co., Ltd., Osaka, Japan
Abstract
It has been shown that molecular hydrogen (H2) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson’s disease (PD).Here, we show that drinking H2-containing water significantly reduced the loss of dopaminergic neurons in PD model mice using both acute and chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The concentrationdependency of H2 showed that H2 as low as 0.08 ppm had almost the same effect as saturated H2 water (1.5 ppm). MPTPinduced accumulation of cellular 8-oxoguanine (8-oxoG), a marker of DNA damage, and 4-hydroxynonenal (4-HNE), a marker of lipid peroxidation were significantly decreased in the nigro-striatal dopaminergic pathway in mice drinking H2- containing water, whereas production of superoxide (O2N2) detected by intravascular injection of dihydroethidium (DHE) was not reduced significantly. Our results indicated that low concentration of H2 in drinking water can reduce oxidative stress in the brain. Thus, drinking H2-containing water may be useful in daily life to prevent or minimize the risk of life stylerelated oxidative stress and neurodegeneration.
Citation: Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, et al. (2009) Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease. PLoS ONE 4(9): e7247. doi:10.1371/journal.pone.0007247 Editor: David C. Rubinsztein, University of Cambridge, United Kingdom Received September 2, 2008; Accepted September 2, 2009; Published September 30, 2009
pdfFujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, & Noda M (2009). Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PloS one, 4 (9) PMID: 19789628https://blog.sciencenet.cn/blog-41174-259104.html
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